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> Protein (NX_Q14161)
Protein (NX_Q14161)
Protein
Gene SymbolGIT2 to neXtProt (NX_Q14161)
DescriptionARF GTPase-activating protein GIT2
Chromosome12
Location12q24.11 (110367607 ~ 110434194) to Ensembl
Sequene Features : Isoforms 11, Variants 74, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.behavioral response to pain
.regulation of G-protein coupled receptor protein signaling pathway
.zinc ion binding
.GTPase activator activity
.focal adhesion
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
11 74 12
2014-09-19protein level
11 59 12
2014-05-27protein level
11 59 12
2014-02-25protein level
11 58 12
2013-12-09protein level
11 47 12
2013-11-01protein level
11 44 12
2013-09-12protein level
11 44 13
2013-08-17protein level
11 44 13
2013-07-15protein level
11 28 13
2013-06-11protein level
11 28 13
2013-02-12protein level
11 15 106
2012-12-20protein level
11 16 106
2012-10-30protein level
11 20 106
2012-10-07protein level
11 20 13
2012-08-24protein level
11 12 13
2012-07-28protein level
11 12 13
2012-06-08protein level
11 13 13
2012-05-07protein level
11 13 13
2012-04-10protein level
11 13 13
2012-01-13protein level
11 9 13
2011-12-20protein level
11 9 13
2011-11-11protein level
11 9 13
2011-08-23protein level
11 4 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14161-1
0 31 3 84490.0012
NX_Q14161-10
2 26 3 76024.7784
NX_Q14161-11
0 25 3 70138.9146
NX_Q14161-2
0 19 3 52544.2044
NX_Q14161-3
0 30 3 82707.0655
NX_Q14161-4
0 28 3 78905.1593
NX_Q14161-5
0 30 3 81271.3674
NX_Q14161-6
0 26 3 73357.5484
NX_Q14161-7
0 26 3 71921.8503
NX_Q14161-8
0 28 3 77469.4612
NX_Q14161-9
0 26 3 72272.9814
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1046878,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
2 EBI-1046878,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
3 EBI-1046878,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
4 EBI-1046878,EBI-1044160 TSN  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.gene expression
.DNA recombination
.sequence-specific DNA binding
.endoribonuclease activity
.mRNA binding
  + 2 more...
.cytosol
.cytoplasm
.nucleus
5 EBI-1046878,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder133
blood98
bone55
bone marrow41
brain79
cervix123
connective tissue67
embryonic tissue18
eye62
heart55
intestine81
kidney66
liver38
lung35
lymph node233
mammary gland39
mouth136
muscle169
nerve64
ovary39
pancreas32
pharynx24
placenta84
prostate15
salivary gland49
skin80
spleen112
stomach52
testis85
thymus263
thyroid21
tonsil176
trachea57
uterus90
vascular38
Health State
TissuesTPM*
normal73
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma96
colorectal tumor53
gastrointestinal tumor59
germ cell tumor79
glioma65
head and neck tumor67
kidney tumor43
leukemia84
liver tumor83
lung tumor19
lymphoma96
non-neoplasia62
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS78
prostate cancer9
retinoblastoma21
skin tumor103
soft tissue/muscle tissue tumor191
uterine tumor99
Developmental Stage
TissuesTPM*
adult62
embryoid body28
blastocyst16
neonate32
fetus96
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.1
adrenal gland17.8
appendix34.7
bone marrow44.9
cerebral cortex13
colon14.1
duodenum12.6
esophagus12.8
gallbladder20.8
heart muscle14.9
kidney11.1
liver7.3
lung18.2
lymph node41.1
ovary21.1
pancreas9.3
placenta21.4
prostate13
salivary gland13.6
skin16.7
small intestine16
spleen44
stomach15.6
testis18.9
thyroid gland20.6
urinary bladder23.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608564, gene) G protein-coupled receptor kinase-interacting protein 2; GIT2OMIM


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