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> Protein (NX_Q14164)
Protein (NX_Q14164)
Protein
Gene SymbolIKBKE to neXtProt (NX_Q14164)
DescriptionInhibitor of nuclear factor kappa-B kinase subunit epsilon
Chromosome1
Location1q32.1 (206643791 ~ 206670223) to Ensembl
Sequene Features : Isoforms 2, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 105 7
2014-09-19protein level
2 72 7
2014-05-27protein level
2 72 7
2014-02-25protein level
2 72 7
2013-12-09protein level
2 56 4
2013-11-01protein level
2 51 4
2013-09-12protein level
2 51 4
2013-08-17protein level
2 51 4
2013-07-15protein level
2 40 3
2013-06-11protein level
2 40 3
2013-02-12protein level
2 26 8
2012-12-20protein level
2 26 8
2012-10-30protein level
2 27 8
2012-10-07protein level
2 27 4
2012-08-24protein level
1 26 4
2012-07-28protein level
1 26 4
2012-06-08protein level
1 32 4
2012-05-07protein level
1 22 4
2012-04-10protein level
1 22 4
2012-01-13protein level
1 16 4
2011-12-20protein level
1 16 4
2011-11-11protein level
1 16 4
2011-08-23protein level
1 16 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14164-1
6 28 2 80411.4735
NX_Q14164-2
1 28 2 70771.3585
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307369,EBI-359969 TBKBP1  
  .innate immune response .N/A .N/A
2 EBI-307369,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
3 EBI-307369,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
4 EBI-307369,EBI-2650369 IRF3  
  .programmed necrotic cell death
.macrophage apoptotic process
.cellular response to dsRNA
  + 28 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-307369,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
6 EBI-307369,EBI-995373 MAVS  
  .regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
7 EBI-307369,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
8 EBI-307369,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
9 EBI-307369,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
blood24
bone27
bone marrow82
brain19
cervix20
connective tissue60
embryonic tissue14
eye28
heart22
intestine21
kidney37
lung59
lymph158
lymph node100
mammary gland66
mouth166
muscle18
ovary9
pancreas9
placenta21
prostate5
skin23
spleen206
stomach20
testis6
thymus376
thyroid21
tonsil58
trachea77
umbilical cord1307
uterus8
vascular58
Health State
TissuesTPM*
normal32
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor25
germ cell tumor30
glioma55
head and neck tumor82
kidney tumor72
lung tumor48
lymphoma207
non-neoplasia103
pancreatic tumor19
prostate cancer9
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
embryoid body14
blastocyst16
neonate64
fetus62
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
adrenal gland1.8
appendix13.3
bone marrow4.6
colon6
duodenum5.4
esophagus7.2
gallbladder4.6
kidney1.8
lung3.4
lymph node18.1
ovary1.1
placenta2.1
prostate2
salivary gland3.7
skin9.3
small intestine6.1
spleen10.3
stomach6.7
thyroid gland3.9
urinary bladder7.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605048, gene) Inhibitor of kappa light polypeptide gene enhancer in b cells, kinaseOMIM


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