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> Protein (NX_Q14185)
Protein (NX_Q14185)
Protein
Gene SymbolDOCK1 to neXtProt (NX_Q14185)
DescriptionDedicator of cytokinesis protein 1
Chromosome10
Location10q26.2 (128593978 ~ 129250781) to Ensembl
Sequene Features : Isoforms 1, Variants 188, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
.positive regulation of GTPase activity
  + 10 more...
.GTPase activator activity
.guanyl-nucleotide exchange factor activity
.membrane
.cytosol
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 188 7
2014-09-19protein level
1 139 7
2014-05-27protein level
1 139 7
2014-02-25protein level
1 136 7
2013-12-09protein level
1 103 7
2013-11-01protein level
1 100 6
2013-09-12protein level
1 100 6
2013-08-17protein level
1 100 6
2013-07-15protein level
1 65 6
2013-06-11protein level
1 65 6
2013-02-12protein level
1 23 4
2012-12-20protein level
1 32 4
2012-10-30protein level
1 39 4
2012-10-07protein level
1 39 4
2012-08-24protein level
1 36 4
2012-07-28protein level
1 36 4
2012-06-08protein level
1 40 4
2012-05-07protein level
1 24 4
2012-04-10protein level
1 24 4
2012-01-13protein level
1 20 4
2011-12-20protein level
1 20 4
2011-11-11protein level
1 20 4
2011-08-23protein level
1 20 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14185-1
87 0 3 215208.3748
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-446740,EBI-359567 ANKRD28  
  .N/A .N/A .nucleoplasm
2 EBI-446740,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-446740,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
4 EBI-446740,EBI-346417 ELMO1  
  .regulation of defense response to virus by virus
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 7 more...
.SH3 domain binding .membrane
.plasma membrane
.cytoskeleton
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites25
bladder33
bone83
brain33
cervix61
connective tissue33
embryonic tissue79
eye19
heart44
intestine77
kidney75
larynx85
liver19
lung20
mammary gland46
mouth136
muscle37
nerve64
ovary39
pancreas84
parathyroid145
placenta45
prostate31
skin28
spleen18
stomach41
testis16
thymus25
trachea38
uterus47
vascular116
Health State
TissuesTPM*
normal43
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma108
colorectal tumor115
gastrointestinal tumor50
germ cell tumor30
glioma46
head and neck tumor82
kidney tumor58
leukemia10
liver tumor20
lung tumor19
non-neoplasia20
ovarian tumor26
pancreatic tumor38
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult55
embryoid body114
blastocyst113
fetus41
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.3
adrenal gland9
appendix8.1
cerebral cortex16.5
colon17.6
duodenum13
esophagus29.1
gallbladder31.8
heart muscle14.2
kidney21.3
liver7.9
lung16.7
lymph node5.9
ovary27.9
pancreas6.8
placenta23.1
prostate19.2
salivary gland13.8
skin48.3
small intestine15.5
spleen10.1
stomach10.2
testis12.7
thyroid gland50.5
urinary bladder23
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601403, gene) Dedicator of cytokinesis 1; DOCK1OMIM


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