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> Protein (NX_Q14191)
Protein (NX_Q14191)
Protein
Gene SymbolWRN to neXtProt (NX_Q14191)
DescriptionWerner syndrome ATP-dependent helicase
Chromosome8
Location8p12 (30891317 ~ 31031285) to Ensembl
Sequene Features : Isoforms 1, Variants 203, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleic acid phosphodiester bond hydrolysis
.cellular response to gamma radiation
.positive regulation of hydrolase activity
  + 23 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.3'-5' DNA helicase activity
  + 15 more...
.centrosome
.nucleolus
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 203 7
2014-09-19protein level
1 159 7
2014-05-27protein level
1 159 7
2014-02-25protein level
1 159 7
2013-12-09protein level
1 128 7
2013-11-01protein level
1 124 7
2013-09-12protein level
1 124 6
2013-08-17protein level
1 124 6
2013-07-15protein level
1 101 6
2013-06-11protein level
1 101 6
2013-02-12protein level
1 66 6
2012-12-20protein level
1 65 6
2012-10-30protein level
1 78 6
2012-10-07protein level
1 78 7
2012-08-24protein level
1 77 7
2012-07-28protein level
1 77 7
2012-06-08protein level
1 89 7
2012-05-07protein level
1 73 7
2012-04-10protein level
1 73 7
2012-01-13protein level
1 55 7
2011-12-20protein level
1 55 7
2011-11-11protein level
1 55 7
2011-08-23protein level
1 55 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14191-1
70 0 0 162356.4899
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-368417,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-368417,EBI-355676 PARP1  
  .positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
3 EBI-368417,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
4 EBI-368417,EBI-621389 RPA1  
  .regulation of cellular response to heat
.error-free translesion synthesis
.homeostasis of number of cells within a tissue
  + 31 more...
.metal ion binding
.single-stranded DNA binding
.damaged DNA binding
.chromatin binding
.PML body
.DNA replication factor A complex
.nucleoplasm
  + 3 more...
5 EBI-368417,EBI-707816 FEN1  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.DNA replication, removal of RNA primer
  + 11 more...
.manganese ion binding
.5'-flap endonuclease activity
.5'-3' exonuclease activity
  + 8 more...
.membrane
.plasma membrane
.mitochondrion
  + 3 more...
6 EBI-368417,EBI-706448 RAD52  
  .regulation of nucleotide-excision repair
.cellular protein metabolic process
.post-translational protein modification
  + 9 more...
.identical protein binding
.DNA binding
.recombinase activity
.nucleoplasm
.nucleus
7 EBI-368417,EBI-621372 BLM  
  .cellular response to camptothecin
.cellular response to hydroxyurea
.cellular response to ionizing radiation
  + 25 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.annealing helicase activity
  + 9 more...
.pronucleus
.PML body
.nuclear matrix
  + 8 more...
8 EBI-368417,EBI-706637 TERF2  
  .negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
  + 15 more...
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
  + 2 more...
.Golgi apparatus
.cytoplasm
.nucleoplasm
  + 5 more...
9 EBI-368417,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
blood8
bone27
bone marrow20
brain6
ear62
embryonic tissue14
eye14
intestine4
kidney4
larynx127
liver19
lung11
lymph node44
mammary gland19
muscle28
pancreas4
placenta10
skin4
testis9
trachea19
uterus4
Health State
TissuesTPM*
normal11
breast (mammary gland) tumor32
chondrosarcoma24
gastrointestinal tumor8
germ cell tumor3
glioma9
head and neck tumor22
kidney tumor14
leukemia10
lung tumor9
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult10
blastocyst48
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland6.1
appendix7.9
bone marrow13
cerebral cortex3
colon5.3
duodenum4.5
esophagus4.8
gallbladder6.2
heart muscle2.5
kidney3.1
liver3.2
lung5.4
lymph node6.3
ovary7.9
pancreas3.1
placenta4.8
prostate5.6
salivary gland5.1
skin7
small intestine4.7
spleen5.7
stomach4.3
testis8.1
thyroid gland5.7
urinary bladder5.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114500, phenotype) Colorectal cancer; CRCOMIM
2(#277700, phenotype) Werner syndrome; WRNOMIM
3(*604611, gene) Recq protein-like 2; RECQL2OMIM
4osteosarcoma;meningioma;others;Werner SyndromeCGP


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