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> Protein (NX_Q14192)
Protein (NX_Q14192)
Protein
Gene SymbolFHL2 to neXtProt (NX_Q14192)
DescriptionFour and a half LIM domains protein 2
Chromosome2
Location2q12.1 (105974169 ~ 106054970) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 3
2014-09-19protein level
1 23 3
2014-05-27protein level
1 23 3
2014-02-25protein level
1 23 3
2013-12-09protein level
1 19 3
2013-11-01protein level
1 19 3
2013-09-12protein level
1 19 3
2013-08-17protein level
1 19 3
2013-07-15protein level
1 15 3
2013-06-11protein level
1 15 3
2013-02-12protein level
1 8 2
2012-12-20protein level
1 8 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 8 2
2012-07-28protein level
1 8 2
2012-06-08protein level
1 8 2
2012-05-07protein level
1 8 2
2012-04-10protein level
1 8 2
2012-01-13protein level
1 8 2
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23protein level
1 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14192-1
14 2 0 32170.5275
NX_Q14192-2
5 2 0 15879.416
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-701903,EBI-2814604 SIGLEC6  
  .cell-cell signaling
.cell adhesion
.carbohydrate binding .membrane
.integral component of plasma membrane
.extracellular region
2 EBI-701903,EBI-702484 JUP  
  .regulation of ventricular cardiac muscle cell action potential
.positive regulation of canonical Wnt signaling pathway
.establishment of protein localization to plasma membrane
  + 20 more...
.cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
.cell adhesion molecule binding
.cadherin binding
  + 7 more...
.gamma-catenin-TCF7L2 complex
.extracellular exosome
.protein-DNA complex
  + 19 more...
3 EBI-701903,EBI-712767 ATF3  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.positive regulation of TRAIL-activated apoptotic signaling pathway
.regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
  + 8 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.protein homodimerization activity
  + 8 more...
.CHOP-ATF3 complex
.nucleolus
.nucleoplasm
.nucleus
4 EBI-701903,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
5 EBI-701903,EBI-742557 RFX3  
  .positive regulation of type B pancreatic cell development
.type B pancreatic cell maturation
.epithelial cilium movement involved in determination of left/right asymmetry
  + 12 more...
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.transcription factor complex
.nucleus
.nuclear chromatin
6 EBI-701903,EBI-10213055 ZNF131  
  .transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
7 EBI-701903,EBI-8651703 SP2  
  .cardiovascular system development
.embryonic organ development
.fibroblast proliferation
  + 5 more...
.metal ion binding
.histone deacetylase binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleoplasm
.nucleus
8 EBI-701903,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
9 EBI-701903,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
10 EBI-701903,EBI-1108782 FOXO1  
  .regulation of energy homeostasis
.regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
  + 38 more...
.protein phosphatase 2A binding
.sequence-specific DNA binding
.ubiquitin protein ligase binding
  + 4 more...
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
11 EBI-701903,EBI-2547810 NRF1  
  .response to electrical stimulus
.response to folic acid
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.cytoplasm
.nucleoplasm
12 EBI-701903,EBI-2804292 GLYR1  
  .pentose-phosphate shunt .NAD binding
.methylated histone binding
.phosphogluconate dehydrogenase (decarboxylating) activity
.DNA binding
.Golgi apparatus
.cytoplasm
.nucleoplasm
13 EBI-701903,EBI-719994 CCDC92  
  .N/A .N/A .centriole
14 EBI-701903,EBI-10188326 KIAA1217  
  .embryonic skeletal system development .N/A .cytoplasm
15 EBI-701903,EBI-2514659 ZMYM4  
  .regulation of cell morphogenesis
.multicellular organismal development
.cytoskeleton organization
.zinc ion binding
.DNA binding
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
16 EBI-701903,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
17 EBI-701903,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
18 EBI-701903,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
19 EBI-701903,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
20 EBI-701903,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
21 EBI-701903,EBI-750254 ARHGAP9  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.small GTPase mediated signal transduction
.phosphatidylinositol-3,4,5-trisphosphate binding
.GTPase activator activity
.cytosol
22 EBI-701903,EBI-6916466 FAM129A  
  .positive regulation of translation
.response to endoplasmic reticulum stress
.positive regulation of protein phosphorylation
.negative regulation of protein phosphorylation
.N/A .extracellular exosome
.membrane
.plasma membrane
.cytoplasm
23 EBI-701903,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
24 EBI-701903,EBI-347633 ZNF408  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.identical protein binding
.DNA binding
.nucleus
25 EBI-701903,EBI-711679 ZFP64  
  .positive regulation of mRNA splicing, via spliceosome
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
26 EBI-701903,EBI-374238 DCP1A  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.identical protein binding
.hydrolase activity
.membrane
.cytosol
.nucleus
.cytoplasmic mRNA processing body
27 EBI-701903,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-701903,EBI-985303 SPHK1  
  .cellular response to growth factor stimulus
.response to interleukin-1
.cellular response to hydrogen peroxide
  + 41 more...
.protein phosphatase 2A binding
.sphingosine-1-phosphate receptor activity
.D-erythro-sphingosine kinase activity
  + 7 more...
.axon
.synaptic vesicle
.plasma membrane
  + 3 more...
29 EBI-701903,EBI-358636 GNG12  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.response to lipopolysaccharide
  + 5 more...
.phosphate ion binding
.PDZ domain binding
.signal transducer activity
.extracellular exosome
.plasma membrane
.actin filament
.heterotrimeric G-protein complex
30 EBI-701903,EBI-746228 RAI2  
  .embryo development .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
bladder33
blood8
bone111
bone marrow41
brain15
cervix82
connective tissue53
embryonic tissue37
esophagus49
eye86
heart368
intestine90
kidney47
larynx42
liver43
lung5
lymph node55
mammary gland85
mouth75
muscle47
ovary78
pancreas79
pituitary gland60
placenta158
prostate58
salivary gland246
skin71
spleen37
stomach240
testis36
thyroid42
umbilical cord145
uterus90
Health State
TissuesTPM*
normal49
bladder carcinoma113
breast (mammary gland) tumor75
chondrosarcoma60
colorectal tumor106
esophageal tumor57
gastrointestinal tumor168
germ cell tumor56
glioma27
head and neck tumor97
kidney tumor58
liver tumor72
non-neoplasia10
ovarian tumor52
pancreatic tumor161
primitive neuroectodermal tumor of the CNS94
prostate cancer9
retinoblastoma64
skin tumor71
soft tissue/muscle tissue tumor63
uterine tumor177
Developmental Stage
TissuesTPM*
adult75
embryoid body100
neonate64
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.1
adrenal gland55.8
appendix29.4
bone marrow9.8
cerebral cortex11.5
colon61.6
duodenum45.1
esophagus53.4
gallbladder86.2
heart muscle515.8
kidney18.4
liver14.6
lung9.9
lymph node16.1
ovary456
pancreas4
placenta73.8
prostate58.9
salivary gland16.1
skin15.6
small intestine45.8
spleen12.5
stomach89.8
testis61.2
thyroid gland21
urinary bladder90.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleHigh
kidneyMedium
lateral ventricleLow
liverLow
lungLow
nasopharynxMedium
oral mucosaLow
ovaryMedium
placentaMedium
prostateLow
rectumMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineLow
smooth muscleLow
soft tissue 1Medium
stomach 1Medium
stomach 2Medium
testisMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602633, gene) Four-and-a-half lim domains 2; FHL2OMIM


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