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> Protein (NX_Q14194)
Protein (NX_Q14194)
Protein
Gene SymbolCRMP1 to neXtProt (NX_Q14194)
DescriptionDihydropyrimidinase-related protein 1
Chromosome4
Location4p16.2 (5749811 ~ 5894785) to Ensembl
Sequene Features : Isoforms 2, Variants 103, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.axon guidance
.nervous system development
.nucleobase-containing compound metabolic process
.microtubule cytoskeleton organization
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds .neuronal cell body
.dendrite
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 103 7
2014-09-19protein level
2 85 7
2014-05-27protein level
2 85 10
2014-02-25protein level
2 84 10
2013-12-09protein level
2 75 10
2013-11-01protein level
2 72 10
2013-09-12protein level
2 72 9
2013-08-17protein level
2 72 9
2013-07-15protein level
2 40 8
2013-06-11protein level
2 40 8
2013-02-12protein level
2 17 13
2012-12-20protein level
2 15 13
2012-10-30protein level
2 19 13
2012-10-07protein level
2 19 7
2012-08-24protein level
2 13 7
2012-07-28protein level
2 13 7
2012-06-08protein level
2 15 7
2012-05-07protein level
2 15 7
2012-04-10protein level
2 15 7
2012-01-13protein level
1 8 7
2011-12-20protein level
1 8 7
2011-11-11protein level
1 8 6
2011-08-23protein level
1 8 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14194-1
1 23 3 62144.5129
NX_Q14194-2
5 23 3 74215.4094
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473101,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
2 EBI-473101,EBI-353844 VIM  
  .lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
3 EBI-473101,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-473101,EBI-10232496 DPYSL3  
  .cellular response to cytokine stimulus
.actin crosslink formation
.positive regulation of filopodium assembly
  + 7 more...
.chondroitin sulfate binding
.SH3 domain binding
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
.exocytic vesicle
.cell body
.filamentous actin
  + 4 more...
5 EBI-473101,EBI-2371151 AP3M1  
  .anterograde synaptic vesicle transport
.anterograde axon cargo transport
.protein targeting to lysosome
.Rab GTPase binding .cytoplasmic vesicle membrane
.clathrin adaptor complex
.Golgi apparatus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
brain461
cervix41
connective tissue13
embryonic tissue93
eye244
heart44
intestine21
kidney4
lung110
mammary gland33
mouth30
muscle94
nerve128
pancreas70
pituitary gland60
placenta24
salivary gland98
stomach31
testis62
uterus8
vascular58
Health State
TissuesTPM*
normal175
bladder carcinoma56
cervical tumor57
gastrointestinal tumor50
germ cell tumor208
glioma242
head and neck tumor22
kidney tumor14
lung tumor184
pancreatic tumor47
primitive neuroectodermal tumor of the CNS228
retinoblastoma452
soft tissue/muscle tissue tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult60
embryoid body42
blastocyst146
fetus719
infant297
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.7
adrenal gland9.5
appendix3.2
cerebral cortex69.1
colon3
duodenum1.5
esophagus2.7
gallbladder5.1
heart muscle1.9
kidney6.9
lung6.4
lymph node1.9
ovary9.2
pancreas2.9
placenta4.5
prostate6.3
salivary gland1.7
skin3.7
small intestine2.6
spleen1.4
stomach4.3
testis4.6
thyroid gland3.3
urinary bladder3.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602462, gene) Collapsin response mediator protein 1; CRMP1OMIM


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