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> Protein (NX_Q14204)
Protein (NX_Q14204)
Protein
Gene SymbolDYNC1H1 to neXtProt (NX_Q14204)
DescriptionCytoplasmic dynein 1 heavy chain 1
Chromosome14
Location14q32.31 (102430865 ~ 102517129) to Ensembl
Sequene Features : Isoforms 1, Variants 415, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of spindle localization
.stress granule assembly
.cytoplasmic mRNA processing body assembly
  + 7 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.filopodium
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 415 23
2014-09-19protein level
1 305 23
2014-05-27protein level
1 305 24
2014-02-25protein level
1 289 23
2013-12-09protein level
1 259 23
2013-11-01protein level
1 246 16
2013-09-12protein level
1 246 19
2013-08-17protein level
1 246 19
2013-07-15protein level
1 139 9
2013-06-11protein level
1 139 9
2013-02-12protein level
1 56 13
2012-12-20protein level
1 56 13
2012-10-30protein level
1 59 13
2012-10-07protein level
1 59 13
2012-08-24protein level
1 53 13
2012-07-28protein level
1 53 13
2012-06-08protein level
1 54 13
2012-05-07protein level
1 25 13
2012-04-10protein level
1 25 13
2012-01-13protein level
1 25 13
2011-12-20protein level
1 24 13
2011-11-11protein level
1 24 13
2011-08-23protein level
1 24 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14204-1
233 0 0 532070.3156
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356015,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-356015,EBI-2010251 PSEN2  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.apoptotic signaling pathway
  + 39 more...
.aspartic-type endopeptidase activity
.endopeptidase activity
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 24 more...
3 EBI-356015,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites150
bladder167
blood65
bone139
bone marrow41
brain306
cervix268
connective tissue73
embryonic tissue248
esophagus49
eye220
heart89
intestine275
kidney204
larynx213
liver82
lung212
lymph90
lymph node311
mammary gland628
mouth393
muscle150
nerve708
ovary108
pancreas84
parathyroid48
pharynx73
pituitary gland60
placenta137
prostate300
salivary gland197
skin260
spleen93
stomach198
testis117
thymus100
thyroid171
tonsil58
trachea96
umbilical cord581
uterus163
vascular96
Health State
TissuesTPM*
normal227
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor601
cervical tumor260
chondrosarcoma193
colorectal tumor382
esophageal tumor57
gastrointestinal tumor236
germ cell tumor186
glioma205
head and neck tumor321
kidney tumor188
leukemia84
liver tumor124
lung tumor233
lymphoma83
non-neoplasia155
ovarian tumor52
pancreatic tumor114
primitive neuroectodermal tumor of the CNS62
prostate cancer240
retinoblastoma150
skin tumor207
soft tissue/muscle tissue tumor87
uterine tumor299
Developmental Stage
TissuesTPM*
adult279
embryoid body228
blastocyst341
neonate257
fetus228
infant127
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue49
adrenal gland53.4
appendix31.4
bone marrow38.6
cerebral cortex80.5
colon40
duodenum27.7
esophagus22.1
gallbladder33.8
heart muscle50
kidney33.1
liver21.1
lung42
lymph node36.3
ovary36.1
pancreas14.2
placenta29.6
prostate48.6
salivary gland31.6
skin96.7
small intestine25.1
spleen42.6
stomach31.1
testis41.1
thyroid gland29.3
urinary bladder26.5
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastMedium
bronchusLow
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2Low
epididymisLow
fallopian tubeMedium
gallbladderLow
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleMedium
lungMedium
lymph nodeLow
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Low
small intestineLow
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#158600, phenotype) Spinal muscular atrophy, lower extremity, autosomal dominant; SMALEDOMIM
2(*600112, gene) Dynein, cytoplasmic 1, heavy chain 1; DYNC1H1OMIM
3(#614228, phenotype) Charcot-marie-tooth disease, axonal, type 2o; CMT2OOMIM
4(#614563, phenotype) Mental retardation, autosomal dominant 13; MRD13OMIM


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