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	> Protein (NX_Q14232) Protein (NX_Q14232) Protein Gene Symbol EIF2B1 to neXtProt (NX_Q14232) Description Translation initiation factor eIF-2B subunit alpha Chromosome 12 Location 12q24.31 (124104953 ~ 124118313) to Ensembl Sequene Features : Isoforms 2, Variants 26, PTMs 1 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .cellular response to stimulus .cellular protein metabolic process .positive regulation of GTPase activity   + 9 more... .enzyme regulator activity .GDP binding .GTP binding .translation initiation factor activity .membrane .plasma membrane .eukaryotic translation initiation factor 2B complex   + 2 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 26 1 2014-09-19 protein level 2 21 1 2014-05-27 protein level 1 21 3 2014-02-25 protein level 1 21 3 2013-12-09 protein level 1 18 3 2013-11-01 protein level 1 16 3 2013-09-12 protein level 1 16 3 2013-08-17 protein level 1 16 3 2013-07-15 protein level 1 12 3 2013-06-11 protein level 1 12 3 2013-02-12 protein level 1 4 3 2012-12-20 protein level 1 3 3 2012-10-30 protein level 1 6 3 2012-10-07 protein level 1 6 3 2012-08-24 protein level 1 5 3 2012-07-28 protein level 1 5 3 2012-06-08 protein level 1 5 3 2012-05-07 protein level 1 5 3 2012-04-10 protein level 1 5 3 2012-01-13 protein level 1 2 3 2011-12-20 protein level 1 2 3 2011-11-11 protein level 1 2 2 2011-08-23 protein level 1 2 2 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q14232-1 8 7 0 33690.6562 NX_Q14232-2 3 7 0 24601.7869 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-491065,EBI-10257497 RD3     .retina development in camera-type eye .response to stimulus .visual perception .N/A .N/A 2 EBI-491065,EBI-741158 WDYHV1     .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol .nucleus 3 EBI-491065,EBI-739467 GORASP2     .organelle organization .mitotic cell cycle .N/A .membrane .Golgi apparatus .Golgi membrane EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adrenal gland 212 ascites 125 bladder 33 blood 122 bone 153 bone marrow 41 brain 65 cervix 164 connective tissue 80 embryonic tissue 61 esophagus 198 eye 67 heart 67 intestine 60 kidney 23 larynx 85 liver 38 lung 47 lymph 45 lymph node 44 mammary gland 66 mouth 876 muscle 18 nerve 128 ovary 68 pancreas 98 parathyroid 48 pharynx 24 pituitary gland 121 placenta 84 prostate 153 skin 61 spleen 149 stomach 219 testis 62 thymus 100 thyroid 107 umbilical cord 145 uterus 43 vascular 58 Health State Tissues TPM* normal 71 adrenal tumor 79 breast (mammary gland) tumor 53 cervical tumor 57 chondrosarcoma 144 colorectal tumor 44 esophageal tumor 173 gastrointestinal tumor 168 germ cell tumor 45 glioma 18 head and neck tumor 493 kidney tumor 14 leukemia 84 liver tumor 62 lung tumor 38 lymphoma 41 non-neoplasia 51 ovarian tumor 91 pancreatic tumor 85 primitive neuroectodermal tumor of the CNS 275 prostate cancer 240 retinoblastoma 129 skin tumor 79 soft tissue/muscle tissue tumor 47 uterine tumor 44 Developmental Stage Tissues TPM* adult 112 embryoid body 42 blastocyst 65 neonate 64 fetus 75 infant 595 juvenile 143 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 24.8 adrenal gland 26.9 appendix 29.4 bone marrow 20.1 cerebral cortex 20.6 colon 26.5 duodenum 22.9 esophagus 27.9 gallbladder 24.1 heart muscle 19.1 kidney 21.1 liver 14.5 lung 24 lymph node 35.2 ovary 26 pancreas 11.9 placenta 28 prostate 23.5 salivary gland 17.7 skin 32.2 small intestine 23.3 spleen 27.1 stomach 21 testis 23.6 thyroid gland 22.9 urinary bladder 26.7 Tissues Tissues Expression level adrenal gland Medium appendix Medium bone marrow Medium breast Medium bronchus Low cerebellum Low cerebral cortex Medium cervix, uterine Medium colon Medium duodenum Medium endometrium 1 Low endometrium 2 Medium epididymis Medium esophagus Medium fallopian tube Medium gallbladder Medium hippocampus Medium kidney Medium lateral ventricle Medium liver Low lung Medium lymph node Low nasopharynx Medium oral mucosa Low pancreas Medium placenta Medium prostate Medium rectum Medium salivary gland Medium seminal vesicle Medium skeletal muscle Low skin 1 Medium skin 2 Low small intestine Medium smooth muscle Low soft tissue 1 Low soft tissue 2 Low spleen Medium stomach 1 Low stomach 2 Medium testis Medium thyroid gland Medium tonsil Low urinary bladder Medium vagina Medium Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (#603896, phenotype) Leukoencephalopathy with vanishing white matter; VWM OMIM 2 (*606686, gene) Eukaryotic translation initiation factor 2b, subunit 1; EIF2B1 OMIM

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