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Protein |
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Gene Symbol | EIF2B1 to neXtProt (NX_Q14232) |
Description | Translation initiation factor eIF-2B subunit alpha |
Chromosome | 12 |
Location | 12q24.31 (124104953 ~ 124118313) to Ensembl |
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Sequene Features : Isoforms 2, Variants 26, PTMs 1 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.cellular response to stimulus .cellular protein metabolic process .positive regulation of GTPase activity + 9 more... |
.enzyme regulator activity .GDP binding .GTP binding .translation initiation factor activity |
.membrane .plasma membrane .eukaryotic translation initiation factor 2B complex + 2 more... |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 26 |
| 1 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 21 |
| 1 |
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2014-05-27 | | protein level | | | | | | | 1 |
| 21 |
| 3 |
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2014-02-25 | | protein level | | | | | | | 1 |
| 21 |
| 3 |
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2013-12-09 | | protein level | | | | | | | 1 |
| 18 |
| 3 |
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2013-11-01 | | protein level | | | | | | | 1 |
| 16 |
| 3 |
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2013-09-12 | | protein level | | | | | | | 1 |
| 16 |
| 3 |
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2013-08-17 | | protein level | | | | | | | 1 |
| 16 |
| 3 |
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2013-07-15 | | protein level | | | | | | | 1 |
| 12 |
| 3 |
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2013-06-11 | | protein level | | | | | | | 1 |
| 12 |
| 3 |
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2013-02-12 | | protein level | | | | | | | 1 |
| 4 |
| 3 |
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2012-12-20 | | protein level | | | | | | | 1 |
| 3 |
| 3 |
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2012-10-30 | | protein level | | | | | | | 1 |
| 6 |
| 3 |
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2012-10-07 | | protein level | | | | | | | 1 |
| 6 |
| 3 |
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2012-08-24 | | protein level | | | | | | | 1 |
| 5 |
| 3 |
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2012-07-28 | | protein level | | | | | | | 1 |
| 5 |
| 3 |
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2012-06-08 | | protein level | | | | | | | 1 |
| 5 |
| 3 |
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2012-05-07 | | protein level | | | | | | | 1 |
| 5 |
| 3 |
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2012-04-10 | | protein level | | | | | | | 1 |
| 5 |
| 3 |
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2012-01-13 | | protein level | | | | | | | 1 |
| 2 |
| 3 |
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2011-12-20 | | protein level | | | | | | | 1 |
| 2 |
| 3 |
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2011-11-11 | | protein level | | | | | | | 1 |
| 2 |
| 2 |
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2011-08-23 | | protein level | | | | | | | 1 |
| 2 |
| 2 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-491065,EBI-10257497 |
RD3 |
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.retina development in camera-type eye .response to stimulus .visual perception |
.N/A |
.N/A |
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2 |
EBI-491065,EBI-741158 |
WDYHV1 |
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.cellular protein modification process |
.protein-N-terminal glutamine amidohydrolase activity |
.cytosol .nucleus |
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3 |
EBI-491065,EBI-739467 |
GORASP2 |
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.organelle organization .mitotic cell cycle |
.N/A |
.membrane .Golgi apparatus .Golgi membrane |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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adrenal gland | 212 | |
ascites | 125 | |
bladder | 33 | |
blood | 122 | |
bone | 153 | |
bone marrow | 41 | |
brain | 65 | |
cervix | 164 | |
connective tissue | 80 | |
embryonic tissue | 61 | |
esophagus | 198 | |
eye | 67 | |
heart | 67 | |
intestine | 60 | |
kidney | 23 | |
larynx | 85 | |
liver | 38 | |
lung | 47 | |
lymph | 45 | |
lymph node | 44 | |
mammary gland | 66 | |
mouth | 876 | |
muscle | 18 | |
nerve | 128 | |
ovary | 68 | |
pancreas | 98 | |
parathyroid | 48 | |
pharynx | 24 | |
pituitary gland | 121 | |
placenta | 84 | |
prostate | 153 | |
skin | 61 | |
spleen | 149 | |
stomach | 219 | |
testis | 62 | |
thymus | 100 | |
thyroid | 107 | |
umbilical cord | 145 | |
uterus | 43 | |
vascular | 58 | |
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Health State | |
Tissues | TPM* | |
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normal | 71 | |
adrenal tumor | 79 | |
breast (mammary gland) tumor | 53 | |
cervical tumor | 57 | |
chondrosarcoma | 144 | |
colorectal tumor | 44 | |
esophageal tumor | 173 | |
gastrointestinal tumor | 168 | |
germ cell tumor | 45 | |
glioma | 18 | |
head and neck tumor | 493 | |
kidney tumor | 14 | |
leukemia | 84 | |
liver tumor | 62 | |
lung tumor | 38 | |
lymphoma | 41 | |
non-neoplasia | 51 | |
ovarian tumor | 91 | |
pancreatic tumor | 85 | |
primitive neuroectodermal tumor of the CNS | 275 | |
prostate cancer | 240 | |
retinoblastoma | 129 | |
skin tumor | 79 | |
soft tissue/muscle tissue tumor | 47 | |
uterine tumor | 44 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 112 | |
embryoid body | 42 | |
blastocyst | 65 | |
neonate | 64 | |
fetus | 75 | |
infant | 595 | |
juvenile | 143 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 24.8 | |
adrenal gland | 26.9 | |
appendix | 29.4 | |
bone marrow | 20.1 | |
cerebral cortex | 20.6 | |
colon | 26.5 | |
duodenum | 22.9 | |
esophagus | 27.9 | |
gallbladder | 24.1 | |
heart muscle | 19.1 | |
kidney | 21.1 | |
liver | 14.5 | |
lung | 24 | |
lymph node | 35.2 | |
ovary | 26 | |
pancreas | 11.9 | |
placenta | 28 | |
prostate | 23.5 | |
salivary gland | 17.7 | |
skin | 32.2 | |
small intestine | 23.3 | |
spleen | 27.1 | |
stomach | 21 | |
testis | 23.6 | |
thyroid gland | 22.9 | |
urinary bladder | 26.7 | |
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Tissues | |
Tissues | Expression level |
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adrenal gland | Medium | |
appendix | Medium | |
bone marrow | Medium | |
breast | Medium | |
bronchus | Low | |
cerebellum | Low | |
cerebral cortex | Medium | |
cervix, uterine | Medium | |
colon | Medium | |
duodenum | Medium | |
endometrium 1 | Low | |
endometrium 2 | Medium | |
epididymis | Medium | |
esophagus | Medium | |
fallopian tube | Medium | |
gallbladder | Medium | |
hippocampus | Medium | |
kidney | Medium | |
lateral ventricle | Medium | |
liver | Low | |
lung | Medium | |
lymph node | Low | |
nasopharynx | Medium | |
oral mucosa | Low | |
pancreas | Medium | |
placenta | Medium | |
prostate | Medium | |
rectum | Medium | |
salivary gland | Medium | |
seminal vesicle | Medium | |
skeletal muscle | Low | |
skin 1 | Medium | |
skin 2 | Low | |
small intestine | Medium | |
smooth muscle | Low | |
soft tissue 1 | Low | |
soft tissue 2 | Low | |
spleen | Medium | |
stomach 1 | Low | |
stomach 2 | Medium | |
testis | Medium | |
thyroid gland | Medium | |
tonsil | Low | |
urinary bladder | Medium | |
vagina | Medium | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Expression level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (#603896, phenotype) Leukoencephalopathy with vanishing white matter; VWM | OMIM |
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2 | (*606686, gene) Eukaryotic translation initiation factor 2b, subunit 1; EIF2B1 | OMIM |
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