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> Protein (NX_Q14232)
Protein (NX_Q14232)
Protein
Gene SymbolEIF2B1 to neXtProt (NX_Q14232)
DescriptionTranslation initiation factor eIF-2B subunit alpha
Chromosome12
Location12q24.31 (124104953 ~ 124118313) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to stimulus
.cellular protein metabolic process
.positive regulation of GTPase activity
  + 9 more...
.enzyme regulator activity
.GDP binding
.GTP binding
.translation initiation factor activity
.membrane
.plasma membrane
.eukaryotic translation initiation factor 2B complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 1
2014-09-19protein level
2 21 1
2014-05-27protein level
1 21 3
2014-02-25protein level
1 21 3
2013-12-09protein level
1 18 3
2013-11-01protein level
1 16 3
2013-09-12protein level
1 16 3
2013-08-17protein level
1 16 3
2013-07-15protein level
1 12 3
2013-06-11protein level
1 12 3
2013-02-12protein level
1 4 3
2012-12-20protein level
1 3 3
2012-10-30protein level
1 6 3
2012-10-07protein level
1 6 3
2012-08-24protein level
1 5 3
2012-07-28protein level
1 5 3
2012-06-08protein level
1 5 3
2012-05-07protein level
1 5 3
2012-04-10protein level
1 5 3
2012-01-13protein level
1 2 3
2011-12-20protein level
1 2 3
2011-11-11protein level
1 2 2
2011-08-23protein level
1 2 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14232-1
8 7 0 33690.6562
NX_Q14232-2
3 7 0 24601.7869
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-491065,EBI-10257497 RD3  
  .retina development in camera-type eye
.response to stimulus
.visual perception
.N/A .N/A
2 EBI-491065,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
3 EBI-491065,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland212
ascites125
bladder33
blood122
bone153
bone marrow41
brain65
cervix164
connective tissue80
embryonic tissue61
esophagus198
eye67
heart67
intestine60
kidney23
larynx85
liver38
lung47
lymph45
lymph node44
mammary gland66
mouth876
muscle18
nerve128
ovary68
pancreas98
parathyroid48
pharynx24
pituitary gland121
placenta84
prostate153
skin61
spleen149
stomach219
testis62
thymus100
thyroid107
umbilical cord145
uterus43
vascular58
Health State
TissuesTPM*
normal71
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma144
colorectal tumor44
esophageal tumor173
gastrointestinal tumor168
germ cell tumor45
glioma18
head and neck tumor493
kidney tumor14
leukemia84
liver tumor62
lung tumor38
lymphoma41
non-neoplasia51
ovarian tumor91
pancreatic tumor85
primitive neuroectodermal tumor of the CNS275
prostate cancer240
retinoblastoma129
skin tumor79
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult112
embryoid body42
blastocyst65
neonate64
fetus75
infant595
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.8
adrenal gland26.9
appendix29.4
bone marrow20.1
cerebral cortex20.6
colon26.5
duodenum22.9
esophagus27.9
gallbladder24.1
heart muscle19.1
kidney21.1
liver14.5
lung24
lymph node35.2
ovary26
pancreas11.9
placenta28
prostate23.5
salivary gland17.7
skin32.2
small intestine23.3
spleen27.1
stomach21
testis23.6
thyroid gland22.9
urinary bladder26.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
pancreasMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Low
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603896, phenotype) Leukoencephalopathy with vanishing white matter; VWMOMIM
2(*606686, gene) Eukaryotic translation initiation factor 2b, subunit 1; EIF2B1OMIM


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