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> Protein (NX_Q14241)
Protein (NX_Q14241)
Protein
Gene SymbolTCEB3 to neXtProt (NX_Q14241)
DescriptionTranscription elongation factor B polypeptide 3
Chromosome1
Location1p36.11 (24069645 ~ 24088549) to Ensembl
Sequene Features : Isoforms 1, Variants 83, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral transcription
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.viral process
  + 4 more...
.DNA binding .elongin complex
.integral component of membrane
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 83 7
2014-09-19protein level
1 65 7
2014-05-27protein level
1 65 8
2014-02-25protein level
1 65 7
2013-12-09protein level
1 51 7
2013-11-01protein level
1 48 7
2013-09-12protein level
1 48 7
2013-08-17protein level
1 48 7
2013-07-15protein level
1 32 7
2013-06-11protein level
1 32 7
2013-02-12protein level
1 21 7
2012-12-20protein level
1 23 7
2012-10-30protein level
1 25 7
2012-10-07protein level
1 25 7
2012-08-24protein level
1 25 7
2012-07-28protein level
1 25 7
2012-06-08protein level
1 26 7
2012-05-07protein level
1 21 7
2012-04-10protein level
1 21 7
2012-01-13protein level
1 8 7
2011-12-20protein level
1 8 7
2011-11-11protein level
1 8 5
2011-08-23protein level
1 8 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14241-1
31 0 0 89853.0146
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742350,EBI-746202 PLK4  
  .de novo centriole assembly
.trophoblast giant cell differentiation
.positive regulation of centriole replication
  + 5 more...
.ATP binding
.protein serine/threonine kinase activity
.deuterosome
.cleavage furrow
.cytosol
  + 3 more...
2 EBI-742350,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
3 EBI-742350,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
4 EBI-742350,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
5 EBI-742350,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
6 EBI-742350,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
7 EBI-742350,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
8 EBI-742350,EBI-752007 JAKMIP2  
  .N/A .N/A .Golgi apparatus
9 EBI-742350,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
10 EBI-742350,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
11 EBI-742350,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites175
bladder100
blood40
bone69
bone marrow82
brain32
cervix41
connective tissue67
embryonic tissue46
esophagus99
eye47
heart22
intestine73
kidney52
liver53
lung95
lymph22
lymph node167
mammary gland112
mouth45
muscle18
ovary98
pancreas93
pharynx49
placenta31
prostate58
skin94
spleen74
testis98
thyroid107
tonsil117
trachea57
uterus38
vascular38
Health State
TissuesTPM*
normal53
bladder carcinoma113
breast (mammary gland) tumor139
cervical tumor28
chondrosarcoma132
colorectal tumor62
esophageal tumor115
gastrointestinal tumor84
germ cell tumor72
glioma37
head and neck tumor37
kidney tumor14
leukemia74
liver tumor62
lung tumor68
lymphoma69
non-neoplasia41
ovarian tumor131
pancreatic tumor85
primitive neuroectodermal tumor of the CNS62
prostate cancer67
retinoblastoma129
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult54
embryoid body14
blastocyst81
neonate64
fetus68
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.8
adrenal gland12
appendix18.5
bone marrow19.6
cerebral cortex9.6
colon15.3
duodenum11.5
esophagus23.2
gallbladder16.8
heart muscle12.1
kidney13.1
liver14.5
lung22.8
lymph node17.1
ovary15.7
pancreas20.6
placenta18
prostate12.4
salivary gland12.3
skin16.7
small intestine11.1
spleen15.3
stomach21.5
testis22.2
thyroid gland23
urinary bladder19.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Low
soft tissue 2Low
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600786, gene) Transcription elongation factor b, polypeptide 3; TCEB3OMIM


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