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> Protein (NX_Q14247)
Protein (NX_Q14247)
Protein
Gene SymbolCTTN to neXtProt (NX_Q14247)
DescriptionSrc substrate cortactin
Chromosome11
Location11q13.3 (70244510 ~ 70282690) to Ensembl
Sequene Features : Isoforms 3, Variants 88, PTMs 35 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 88 35
2014-09-19protein level
3 66 35
2014-05-27protein level
3 66 35
2014-02-25protein level
3 65 30
2013-12-09protein level
3 54 30
2013-11-01protein level
3 50 20
2013-09-12protein level
3 50 20
2013-08-17protein level
3 50 20
2013-07-15protein level
3 41 20
2013-06-11protein level
3 41 20
2013-02-12protein level
3 22 76
2012-12-20protein level
3 21 70
2012-10-30protein level
3 23 70
2012-10-07protein level
3 23 24
2012-08-24protein level
3 18 24
2012-07-28protein level
3 19 24
2012-06-08protein level
3 20 24
2012-05-07protein level
3 15 24
2012-04-10protein level
1 12 24
2012-01-13protein level
1 4 24
2011-12-20protein level
1 4 24
2011-11-11protein level
1 4 23
2011-08-23protein level
1 4 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14247-1
2 20 0 61548.3601
NX_Q14247-2
5 19 0 70914.4466
NX_Q14247-3
0 20 0 57431.3786
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351886,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-351886,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
3 EBI-351886,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
4 EBI-351886,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
5 EBI-351886,EBI-346547 DNM2  
  .negative regulation of membrane tubulation
.membrane organization
.regulation of nitric-oxide synthase activity
  + 16 more...
.enzyme binding
.SH3 domain binding
.microtubule binding
  + 2 more...
.extracellular exosome
.postsynaptic membrane
.endocytic vesicle membrane
  + 10 more...
6 EBI-351886,EBI-301697 HDAC6  
  .positive regulation of hydrogen peroxide-mediated programmed cell death
.tubulin deacetylation
.positive regulation of chaperone-mediated protein complex assembly
  + 38 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.dynein complex binding
.Hsp90 protein binding
  + 16 more...
.perinuclear region of cytoplasm
.perikaryon
.cell leading edge
  + 13 more...
7 EBI-351886,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites100
bladder267
blood16
bone181
brain69
cervix82
connective tissue107
embryonic tissue112
eye76
heart122
intestine137
kidney123
larynx511
liver53
lung77
lymph node55
mammary gland125
mouth317
muscle103
ovary78
pancreas121
parathyroid145
pharynx441
placenta123
prostate247
skin398
spleen56
stomach104
testis110
thymus50
thyroid85
trachea77
uterus163
vascular38
Health State
TissuesTPM*
normal106
bladder carcinoma341
breast (mammary gland) tumor161
cervical tumor57
chondrosarcoma108
colorectal tumor222
gastrointestinal tumor135
germ cell tumor106
glioma46
head and neck tumor396
kidney tumor101
liver tumor83
lung tumor48
non-neoplasia62
ovarian tumor78
pancreatic tumor228
primitive neuroectodermal tumor of the CNS102
prostate cancer154
skin tumor215
soft tissue/muscle tissue tumor71
uterine tumor122
Developmental Stage
TissuesTPM*
adult149
embryoid body157
blastocyst113
neonate64
fetus80
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue74.6
adrenal gland117.2
appendix43.9
bone marrow8.4
cerebral cortex66.6
colon73.1
duodenum86.2
esophagus85.8
gallbladder120.6
heart muscle64.9
kidney67.3
liver27.1
lung87.3
lymph node27.6
ovary128.4
pancreas35.8
placenta75.9
prostate93.1
salivary gland66.1
skin120.2
small intestine84.6
spleen66.1
stomach116.7
testis86.2
thyroid gland88.5
urinary bladder85.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164765, gene) Cortactin; CTTNOMIM


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