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> Protein (NX_Q14451)
Protein (NX_Q14451)
Protein
Gene SymbolGRB7 to neXtProt (NX_Q14451)
DescriptionGrowth factor receptor-bound protein 7
Chromosome17
Location17q12 (37894180 ~ 37903544) to Ensembl
Sequene Features : Isoforms 4, Variants 97, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 97 3
2014-09-19protein level
4 79 3
2014-05-27protein level
4 79 3
2014-02-25protein level
4 78 3
2013-12-09protein level
4 49 3
2013-11-01protein level
4 40 3
2013-09-12protein level
4 40 5
2013-08-17protein level
4 40 5
2013-07-15protein level
4 33 5
2013-06-11protein level
4 33 5
2013-02-12protein level
4 19 24
2012-12-20protein level
4 20 24
2012-10-30protein level
4 18 24
2012-10-07protein level
4 18 6
2012-08-24protein level
4 17 6
2012-07-28protein level
4 17 6
2012-06-08protein level
4 31 6
2012-05-07protein level
4 26 6
2012-04-10protein level
4 26 6
2012-01-13protein level
4 23 6
2011-12-20protein level
4 23 4
2011-11-11protein level
4 23 4
2011-08-23protein level
2 8 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14451-1
0 28 0 59643.1806
NX_Q14451-2
2 20 0 49391.7728
NX_Q14451-3
1 27 0 62024.3107
NX_Q14451-4
1 26 0 55884.2753
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-970191,EBI-357001 HAX1  
  .positive regulation of actin cytoskeleton reorganization
.regulation of protein targeting to mitochondrion
.regulation of mitochondrion degradation
  + 10 more...
.protein N-terminus binding
.interleukin-1 binding
.nuclear membrane
.clathrin-coated vesicle
.lamellipodium
  + 9 more...
2 EBI-970191,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-970191,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
4 EBI-970191,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
5 EBI-970191,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
6 EBI-970191,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
7 EBI-970191,EBI-80252 EPHB1  
  .regulation of neuron death
.regulation of ERK1 and ERK2 cascade
.neural precursor cell proliferation
  + 17 more...
.axon guidance receptor activity
.ATP binding
.transmembrane-ephrin receptor activity
.extracellular exosome
.membrane raft
.early endosome membrane
  + 6 more...
8 EBI-970191,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
9 EBI-970191,EBI-10232942 LAX1  
  .negative regulation of T cell activation
.antigen receptor-mediated signaling pathway
.immunoglobulin secretion
  + 4 more...
.SH2 domain binding
.protein kinase binding
.integral component of membrane
.membrane
.plasma membrane
  + 2 more...
10 EBI-970191,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
11 EBI-970191,EBI-3867416 OLIG1  
  .neuron fate commitment
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
12 EBI-970191,EBI-448618 RND1  
  .neuron remodeling
.metabolic process
.axon guidance
  + 3 more...
.GTP binding
.receptor binding
.GTPase activity
.adherens junction
.plasma membrane
.cytoskeleton
.cytosol
13 EBI-970191,EBI-2341518 TRIM36  
  .regulation of cell cycle
.acrosome reaction
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.cytoskeleton
.acrosomal vesicle
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder33
brain16
cervix123
connective tissue6
embryonic tissue18
esophagus148
eye4
intestine86
kidney37
larynx85
liver43
lung23
lymph node22
mammary gland79
mouth120
ovary108
pancreas37
pharynx24
placenta74
prostate47
skin4
stomach10
testis9
thymus12
trachea57
uterus51
Health State
TissuesTPM*
normal29
bladder carcinoma56
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma12
colorectal tumor106
esophageal tumor173
gastrointestinal tumor16
germ cell tumor30
head and neck tumor52
leukemia52
liver tumor93
lung tumor19
ovarian tumor144
pancreatic tumor19
uterine tumor110
Developmental Stage
TissuesTPM*
adult35
embryoid body14
blastocyst32
fetus7
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1.3
colon7.6
duodenum11.8
esophagus22
gallbladder11.6
kidney24.7
liver3.7
lung16.3
pancreas18.2
placenta21.3
prostate7.8
salivary gland15.2
skin19.6
small intestine10.5
stomach11.6
testis1.4
thyroid gland3.6
urinary bladder8.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601522, gene) Growth factor receptor-bound protein 7; GRB7OMIM


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