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> Protein (NX_Q14457)
Protein (NX_Q14457)
Protein
Gene SymbolBECN1 to neXtProt (NX_Q14457)
DescriptionBeclin-1
Chromosome17
Location17q21.31 (40962152 ~ 40985367) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 3
2014-09-19protein level
1 27 3
2014-05-27protein level
1 27 3
2014-02-25protein level
1 27 3
2013-12-09protein level
1 20 3
2013-11-01protein level
1 19 2
2013-09-12protein level
1 19 1
2013-08-17protein level
1 19 1
2013-07-15protein level
1 14 1
2013-06-11protein level
1 14 1
2013-02-12protein level
1 8 9
2012-12-20protein level
1 8 9
2012-10-30protein level
1 10 9
2012-10-07protein level
1 10 9
2012-08-24protein level
1 7 9
2012-07-28protein level
1 7 9
2012-06-08protein level
1 8 9
2012-05-07protein level
1 7 9
2012-04-10protein level
1 7 9
2012-01-13protein level
1 5 9
2011-12-20protein level
1 5 9
2011-11-11protein level
1 5 8
2011-08-23protein level
1 5 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14457-1
19 0 0 51863.2909
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-949378,EBI-6160405 WASH1  
  .retrograde transport, endosome to plasma membrane
.retrograde transport, endosome to Golgi
.Arp2/3 complex-mediated actin nucleation
  + 6 more...
.alpha-tubulin binding
.ubiquitin protein ligase binding
.invadopodium
.WASH complex
.recycling endosome membrane
  + 7 more...
2 EBI-949378,EBI-518823 BIRC5  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.mitotic spindle assembly
.establishment of chromosome localization
  + 19 more...
.chaperone binding
.cobalt ion binding
.cofactor binding
  + 12 more...
.chromosome passenger complex
.interphase microtubule organizing center
.midbody
  + 11 more...
3 EBI-949378,EBI-1001132 ZWINT  
  .establishment of localization in cell
.cell division
.small GTPase mediated signal transduction
  + 3 more...
.protein N-terminus binding .dendrite
.cytosol
.cytoplasm
  + 3 more...
4 EBI-949378,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
5 EBI-949378,EBI-389432 HMGB1  
  .negative regulation of apoptotic cell clearance
.DNA ligation involved in DNA repair
.positive chemotaxis
  + 23 more...
.repressing transcription factor binding
.RAGE receptor binding
.poly(A) RNA binding
  + 9 more...
.cell surface
.nucleoplasm
.nucleus
  + 3 more...
6 EBI-949378,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
7 EBI-949378,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
8 EBI-949378,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
9 EBI-949378,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
10 EBI-949378,EBI-2690371 ATG14  
  .activation of mitophagy in response to mitochondrial depolarization
.regulation of triglyceride metabolic process
.regulation of protein complex stability
  + 8 more...
.N/A .extrinsic component of pre-autophagosomal structure membrane
.extrinsic component of omegasome membrane
.phagocytic vesicle
  + 8 more...
11 EBI-949378,EBI-742102 EXOC8  
  .membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
12 EBI-949378,EBI-359964 TAB3  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 19 more...
.zinc ion binding .extracellular exosome
.endosome membrane
.plasma membrane
  + 3 more...
13 EBI-949378,EBI-1056470 PIK3C3  
  .regulation of protein secretion
.phosphatidylinositol-mediated signaling
.phosphatidylinositol phosphorylation
  + 20 more...
.1-phosphatidylinositol-3-kinase activity
.ATP binding
.protein kinase activity
.phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 8 more...
14 EBI-949378,EBI-2512975 AMBRA1  
  .regulation of autophagic vacuole assembly
.positive regulation of mitochondrion degradation
.activation of mitophagy in response to mitochondrial depolarization
  + 6 more...
.ubiquitin protein ligase binding .phagocytic vesicle
.intracellular membrane-bounded organelle
.axoneme
  + 5 more...
15 EBI-949378,EBI-358708 TAB2  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 23 more...
.K63-linked polyubiquitin binding
.zinc ion binding
.endosome membrane
.plasma membrane
.cytosol
16 EBI-949378,EBI-2952704 UVRAG  
  .double-strand break repair via classical nonhomologous end joining
.regulation of protein serine/threonine kinase activity
.regulation of vesicle-mediated transport
  + 10 more...
.SNARE binding .phagocytic vesicle
.protein complex
.midbody
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites25
bladder100
blood57
bone27
bone marrow143
brain73
cervix164
connective tissue80
ear62
embryonic tissue42
esophagus49
eye81
heart167
intestine77
kidney56
liver141
lung101
lymph45
lymph node111
mammary gland52
mouth15
muscle47
nerve64
ovary49
pancreas70
parathyroid145
pharynx49
pituitary gland121
placenta74
prostate94
salivary gland49
skin71
spleen168
stomach114
testis107
thymus50
thyroid85
trachea19
uterus81
vascular174
Health State
TissuesTPM*
normal87
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor231
chondrosarcoma36
colorectal tumor79
esophageal tumor57
gastrointestinal tumor67
germ cell tumor56
glioma37
head and neck tumor37
kidney tumor58
leukemia74
liver tumor239
lung tumor38
lymphoma138
non-neoplasia62
ovarian tumor65
pancreatic tumor95
primitive neuroectodermal tumor of the CNS94
prostate cancer48
retinoblastoma86
skin tumor55
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult75
embryoid body57
blastocyst65
fetus62
infant85
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue46.3
adrenal gland47.7
appendix59.7
bone marrow49.4
cerebral cortex40.1
colon71
duodenum62.7
esophagus53.2
gallbladder47.5
heart muscle51.7
kidney47.4
liver26.4
lung46.4
lymph node63.8
ovary34.3
pancreas21.7
placenta30.8
prostate50.1
salivary gland29.5
skin38.5
small intestine58.6
spleen53.4
stomach59.8
testis35.8
thyroid gland48.9
urinary bladder59.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604378, gene) Beclin 1; BECN1OMIM


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