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> Protein (NX_Q14498)
Protein (NX_Q14498)
Protein
Gene SymbolRBM39 to neXtProt (NX_Q14498)
DescriptionRNA-binding protein 39
Chromosome20
Location20q11.22 (34291531 ~ 34330234) to Ensembl
Sequene Features : Isoforms 3, Variants 64, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 64 17
2014-09-19protein level
3 53 17
2014-05-27protein level
3 53 17
2014-02-25protein level
3 52 16
2013-12-09protein level
3 48 16
2013-11-01protein level
3 46 16
2013-09-12protein level
3 46 16
2013-08-17protein level
3 46 16
2013-07-15protein level
3 32 14
2013-06-11protein level
3 32 14
2013-02-12protein level
3 13 43
2012-12-20protein level
3 13 43
2012-10-30protein level
3 14 43
2012-10-07protein level
3 14 15
2012-08-24protein level
3 2 15
2012-07-28protein level
3 2 15
2012-06-08protein level
3 2 15
2012-05-07protein level
3 2 15
2012-04-10protein level
2 2 15
2012-01-13protein level
2 5 15
2011-12-20protein level
2 5 15
2011-11-11protein level
2 5 13
2011-08-23protein level
2 5 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14498-1
0 21 2 59342.5193
NX_Q14498-2
1 20 2 58620.1572
NX_Q14498-3
0 20 2 57054.2146
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-395290,EBI-1044156 SAP18  
  .negative regulation of nucleic acid-templated transcription
.negative regulation of mRNA splicing, via spliceosome
.negative regulation of gene expression, epigenetic
  + 9 more...
.poly(A) RNA binding
.transcription corepressor activity
.ASAP complex
.nuclear speck
.cytoplasm
  + 2 more...
2 EBI-395290,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-6654703,EBI-723574 ZBTB22  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
4 EBI-395290,EBI-5280197 PRPF40A  
  .cell division
.regulation of cytokinesis
.cell migration
  + 5 more...
.poly(A) RNA binding .nuclear speck
.nuclear matrix
.membrane
  + 2 more...
5 EBI-6654703,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
6 EBI-395290,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
7 EBI-395290,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
8 EBI-395290,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
9 EBI-6654703,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
10 EBI-395290,EBI-1051785 SRSF11  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
11 EBI-6654703,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
12 EBI-395290,EBI-396072 PPIG  
  .RNA splicing
.protein folding
.protein peptidyl-prolyl isomerization
.poly(A) RNA binding
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
13 EBI-395290,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
14 EBI-395290,EBI-10248982 ARL6IP4  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
15 EBI-395290,EBI-3920396 C11orf57  
  .N/A .N/A .N/A
16 EBI-6654703,EBI-751942 KIAA0907  
  .N/A .RNA binding .N/A
17 EBI-6654703,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
18 EBI-6654703,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
19 EBI-6654703,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
20 EBI-395290,EBI-10268630 SREK1IP1  
  .RNA splicing
.mRNA processing
.zinc ion binding
.nucleic acid binding
.N/A
21 EBI-395290,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
22 EBI-6654703,EBI-2799179 FAM200A  
  .N/A .nucleic acid binding .integral component of membrane
23 EBI-395290,EBI-8466265 AK8  
  .ventricular system development
.nucleoside triphosphate biosynthetic process
.nucleoside diphosphate phosphorylation
.ATP binding
.nucleoside diphosphate kinase activity
.cytidylate kinase activity
.adenylate kinase activity
.cytosol
24 EBI-395290,EBI-539478 SRPK1  
  .regulation of mRNA processing
.regulation of mRNA splicing, via spliceosome
.innate immune response
  + 9 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.nuclear matrix
.plasma membrane
.endoplasmic reticulum
  + 3 more...
25 EBI-395290,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
26 EBI-6654703,EBI-741109 MLX  
  .negative regulation of transcription, DNA-templated
.small molecule metabolic process
.positive regulation of cellular metabolic process
  + 4 more...
.protein heterodimerization activity
.protein homodimerization activity
.transcription factor binding
  + 4 more...
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland121
ascites200
bladder234
blood147
bone181
bone marrow841
brain130
cervix123
connective tissue73
ear248
embryonic tissue267
esophagus347
eye124
heart156
intestine176
kidney109
larynx255
liver238
lung125
lymph203
lymph node155
mammary gland185
mouth120
muscle169
nerve64
ovary118
pancreas107
parathyroid145
pharynx49
pituitary gland363
placenta166
prostate68
salivary gland246
skin99
spleen262
stomach156
testis144
thymus338
thyroid193
tonsil58
trachea96
uterus258
vascular212
Health State
TissuesTPM*
normal163
adrenal tumor79
breast (mammary gland) tumor128
cervical tumor115
chondrosarcoma181
colorectal tumor231
esophageal tumor405
gastrointestinal tumor194
germ cell tumor132
glioma74
head and neck tumor156
kidney tumor72
leukemia518
liver tumor208
lung tumor58
lymphoma193
non-neoplasia103
ovarian tumor144
pancreatic tumor38
primitive neuroectodermal tumor of the CNS141
prostate cancer57
retinoblastoma64
skin tumor63
soft tissue/muscle tissue tumor95
uterine tumor199
Developmental Stage
TissuesTPM*
adult177
embryoid body228
blastocyst374
neonate96
fetus156
infant85
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue127.6
adrenal gland150
appendix181.4
bone marrow498.1
cerebral cortex98.8
colon112.9
duodenum142.3
esophagus124.6
gallbladder162.2
heart muscle96.6
kidney106.1
liver73.8
lung154.2
lymph node234.1
ovary212.8
pancreas79.3
placenta189.2
prostate161.5
salivary gland121.7
skin164.8
small intestine155.9
spleen203.7
stomach153.8
testis103.9
thyroid gland172.9
urinary bladder152.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604739, gene) Rna binding motif protein 39; RBM39OMIM


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2014-2019 (C) Yonsei Proteome Research Center