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> Protein (NX_Q14566)
Protein (NX_Q14566)
Protein
Gene SymbolMCM6 to neXtProt (NX_Q14566)
DescriptionDNA replication licensing factor MCM6
Chromosome2
Location2q21.3 (136597196 ~ 136633996) to Ensembl
Sequene Features : Isoforms 1, Variants 105, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA unwinding involved in DNA replication
  + 3 more...
.identical protein binding
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 105 26
2014-09-19protein level
1 82 26
2014-05-27protein level
1 82 26
2014-02-25protein level
1 82 25
2013-12-09protein level
1 63 25
2013-11-01protein level
1 61 22
2013-09-12protein level
1 61 22
2013-08-17protein level
1 61 22
2013-07-15protein level
1 45 9
2013-06-11protein level
1 45 9
2013-02-12protein level
1 24 8
2012-12-20protein level
1 25 8
2012-10-30protein level
1 33 8
2012-10-07protein level
1 33 8
2012-08-24protein level
1 28 8
2012-07-28protein level
1 28 8
2012-06-08protein level
1 35 8
2012-05-07protein level
1 35 8
2012-04-10protein level
1 35 8
2012-01-13protein level
1 17 8
2011-12-20protein level
1 17 8
2011-11-11protein level
1 17 7
2011-08-23protein level
1 17 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14566-1
36 0 0 92830.9716
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-374900,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
2 EBI-374900,EBI-355153 MCM3  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA replication
  + 2 more...
.ATP binding
.DNA helicase activity
.DNA binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.MCM complex
  + 5 more...
3 EBI-374900,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
4 EBI-374900,EBI-375053 CDKN2A  
  .positive regulation of cellular senescence
.positive regulation of macrophage apoptotic process
.replicative senescence
  + 14 more...
.NF-kappaB binding
.poly(A) RNA binding
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.senescence-associated heterochromatin focus
.cytosol
.cytoplasm
.nucleus
5 EBI-374900,EBI-374819 MCM2  
  .cellular response to interleukin-4
.cell cycle
.nucleosome assembly
  + 6 more...
.metal ion binding
.ATP binding
.DNA replication origin binding
  + 2 more...
.MCM complex
.microtubule cytoskeleton
.cytoplasm
  + 4 more...
6 EBI-374900,EBI-10096247 NUDT2  
  .apoptotic process
.nucleobase-containing compound metabolic process
.bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
.GTP binding
.bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
.mitochondrion
7 EBI-374900,EBI-353771 SSRP1  
  .positive regulation of viral transcription
.viral process
.gene expression
  + 6 more...
.poly(A) RNA binding
.chromatin binding
.DNA binding
.cytoplasm
.nucleolus
.chromosome
  + 2 more...
8 EBI-374900,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
9 EBI-374900,EBI-374912 MCM10  
  .cell proliferation
.DNA replication initiation
.DNA replication
  + 2 more...
.metal ion binding
.identical protein binding
.single-stranded DNA binding
  + 2 more...
.replication fork protection complex
.cytoplasm
.nucleolus
  + 2 more...
10 EBI-374900,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
11 EBI-374900,EBI-749378 MCMBP  
  .cell division
.mitotic nuclear division
.sister chromatid cohesion
.DNA-dependent DNA replication
.chromatin binding .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-374900,EBI-456953 CDT1  
  .regulation of nuclear cell cycle DNA replication
.regulation of DNA-dependent DNA replication initiation
.DNA replication
  + 4 more...
.DNA binding .cytosol
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder33
blood163
bone153
bone marrow102
brain107
cervix226
connective tissue134
ear124
embryonic tissue159
esophagus148
eye105
heart100
intestine116
kidney132
larynx42
liver63
lung26
lymph135
lymph node111
mammary gland145
mouth226
muscle37
nerve64
ovary78
pancreas65
parathyroid48
pharynx24
pituitary gland60
placenta74
prostate79
salivary gland246
skin85
spleen224
stomach20
testis195
thymus552
thyroid21
tonsil176
trachea38
uterus60
vascular116
Health State
TissuesTPM*
normal89
breast (mammary gland) tumor204
cervical tumor318
chondrosarcoma72
colorectal tumor151
esophageal tumor173
gastrointestinal tumor33
germ cell tumor307
glioma65
head and neck tumor127
kidney tumor58
leukemia105
liver tumor41
lung tumor38
lymphoma110
non-neoplasia51
ovarian tumor78
pancreatic tumor133
primitive neuroectodermal tumor of the CNS220
prostate cancer86
retinoblastoma409
skin tumor79
soft tissue/muscle tissue tumor127
uterine tumor44
Developmental Stage
TissuesTPM*
adult104
embryoid body100
blastocyst227
neonate160
fetus179
infant340
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.3
adrenal gland5.1
appendix21.4
bone marrow21
cerebral cortex6.9
colon13.9
duodenum12.2
esophagus9.4
gallbladder7.4
heart muscle4
kidney6
liver6.6
lung6.4
lymph node34
ovary10.9
pancreas1.9
placenta12.2
prostate6.3
salivary gland3.3
skin9.2
small intestine12
spleen8.6
stomach8.3
testis15.5
thyroid gland4.3
urinary bladder12
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineHigh
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusLow
kidneyLow
lateral ventricleLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#223100, phenotype) Lactose intolerance, adult typeOMIM
2(*601806, gene) Minichromosome maintenance, s. pombe, homolog of, 6; MCM6OMIM


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