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> Protein (NX_Q14573)
Protein (NX_Q14573)
Protein
Gene SymbolITPR3 to neXtProt (NX_Q14573)
DescriptionInositol 1,4,5-trisphosphate receptor type 3
Chromosome6
Location6p21.31 (33588142 ~ 33664351) to Ensembl
Sequene Features : Isoforms 1, Variants 308, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.calcium ion transport into cytosol
.long-term synaptic potentiation
.response to calcium ion
  + 24 more...
.inositol 1,4,5 trisphosphate binding
.inositol 1,3,4,5 tetrakisphosphate binding
.phosphatidylinositol binding
  + 3 more...
.apical part of cell
.receptor complex
.myelin sheath
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 308 10
2014-09-19protein level
1 231 10
2014-05-27protein level
1 231 10
2014-02-25protein level
1 229 10
2013-12-09protein level
1 178 10
2013-11-01protein level
1 168 9
2013-09-12protein level
1 168 9
2013-08-17protein level
1 168 9
2013-07-15protein level
1 103 9
2013-06-11protein level
1 103 9
2013-02-12protein level
1 64 6
2012-12-20protein level
1 63 6
2012-10-30protein level
1 71 6
2012-10-07protein level
1 71 6
2012-08-24protein level
1 70 6
2012-07-28protein level
1 70 6
2012-06-08protein level
1 78 6
2012-05-07protein level
1 46 6
2012-04-10protein level
1 46 6
2012-01-13protein level
1 26 6
2011-12-20protein level
1 26 6
2011-11-11protein level
1 26 6
2011-08-23protein level
1 26 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14573-1
117 0 7 303911.2498
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351055,EBI-520807 TRPC3  
  .positive regulation of cardiac muscle hypertrophy in response to stress
.calcium ion transmembrane transport
.transmembrane transport
  + 10 more...
.inositol 1,4,5 trisphosphate binding
.store-operated calcium channel activity
.calcium channel activity
.integral component of plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites125
bladder100
blood16
bone209
bone marrow41
brain21
cervix288
connective tissue100
embryonic tissue18
esophagus198
eye47
heart33
intestine288
kidney56
larynx468
liver38
lung131
lymph90
lymph node289
mammary gland119
mouth136
muscle37
nerve321
ovary49
pancreas112
pharynx73
placenta7
prostate15
skin104
spleen37
stomach73
testis55
thymus100
thyroid601
tonsil117
trachea19
uterus64
vascular19
Health State
TissuesTPM*
normal46
adrenal tumor158
bladder carcinoma227
breast (mammary gland) tumor96
cervical tumor115
chondrosarcoma325
colorectal tumor408
esophageal tumor231
gastrointestinal tumor92
germ cell tumor49
glioma37
head and neck tumor298
kidney tumor87
leukemia148
liver tumor41
lung tumor155
lymphoma55
non-neoplasia124
ovarian tumor26
pancreatic tumor199
retinoblastoma129
skin tumor151
soft tissue/muscle tissue tumor15
uterine tumor133
Developmental Stage
TissuesTPM*
adult111
embryoid body42
blastocyst16
fetus48
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.3
adrenal gland6
appendix15.8
bone marrow3.4
cerebral cortex1.1
colon22.6
duodenum23.9
esophagus10.2
gallbladder15.3
heart muscle4.3
kidney5.1
lung30.9
lymph node17.8
ovary5.8
pancreas3.8
placenta3.3
prostate7.3
salivary gland8.7
skin42.4
small intestine27.7
spleen30
stomach35.9
testis17.4
thyroid gland39.3
urinary bladder9.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147267, gene) Inositol 1,4,5-triphosphate receptor, type 3; ITPR3OMIM


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