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> Protein (NX_Q14596)
Protein (NX_Q14596)
Protein
Gene SymbolNBR1 to neXtProt (NX_Q14596)
DescriptionNext to BRCA1 gene 1 protein
Chromosome17
Location17q21.31 (41322498 ~ 41363708) to Ensembl
Sequene Features : Isoforms 2, Variants 89, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein oligomerization
.negative regulation of osteoblast differentiation
.regulation of stress-activated MAPK cascade
  + 2 more...
.mitogen-activated protein kinase binding
.ubiquitin binding
.zinc ion binding
.extracellular exosome
.M band
.cytoplasmic vesicle
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 89 8
2014-09-19protein level
2 69 8
2014-05-27protein level
2 69 8
2014-02-25protein level
2 69 8
2013-12-09protein level
2 48 8
2013-11-01protein level
2 48 8
2013-09-12protein level
2 48 8
2013-08-17protein level
2 48 8
2013-07-15protein level
2 35 2
2013-06-11protein level
2 35 2
2013-02-12protein level
2 15 2
2012-12-20protein level
2 16 2
2012-10-30protein level
2 20 2
2012-10-07protein level
2 20 1
2012-08-24protein level
2 18 1
2012-07-28protein level
2 18 1
2012-06-08protein level
2 5 1
2012-05-07protein level
2 5 1
2012-04-10protein level
2 5 1
2012-01-13protein level
2 5 1
2011-12-20protein level
2 10 1
2011-11-11protein level
2 10 0
2011-08-23protein level
2 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14596-1
2 34 0 107345.3676
NX_Q14596-2
2 34 0 103768.6408
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742698,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-742698,EBI-1050865 USP8  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 6 more...
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.extrinsic component of endosome membrane
.midbody
.extrinsic component of plasma membrane
  + 6 more...
3 EBI-742698,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-742698,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
5 EBI-742698,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
6 EBI-742698,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
7 EBI-742698,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
8 EBI-742698,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
9 EBI-742698,EBI-751132 SYT4  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.negative regulation of calcium ion-dependent exocytosis
  + 4 more...
.clathrin binding
.syntaxin binding
.calcium ion binding
.phosphatidylserine binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuron projection
  + 5 more...
10 EBI-742698,EBI-720768 MAP1LC3A  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.phosphatidylethanolamine binding
.microtubule binding
.phospholipid binding
.cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland91
ascites75
bladder66
blood65
bone139
brain144
cervix164
connective tissue80
ear62
embryonic tissue75
eye110
heart44
intestine64
kidney80
larynx127
liver92
lung98
lymph45
lymph node133
mammary gland85
mouth256
muscle28
nerve128
ovary39
pancreas42
parathyroid339
placenta109
prostate147
skin128
spleen93
stomach31
testis450
thymus238
thyroid171
trachea502
umbilical cord72
uterus94
vascular38
Health State
TissuesTPM*
normal115
adrenal tumor79
breast (mammary gland) tumor96
cervical tumor231
chondrosarcoma132
colorectal tumor62
gastrointestinal tumor50
germ cell tumor102
glioma102
head and neck tumor171
kidney tumor58
leukemia84
liver tumor104
lung tumor136
lymphoma69
non-neoplasia103
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS15
prostate cancer144
retinoblastoma129
skin tumor119
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult106
embryoid body71
blastocyst113
neonate64
fetus75
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.4
adrenal gland50.1
appendix38.1
bone marrow11.7
cerebral cortex47.2
colon58.8
duodenum53.5
esophagus40
gallbladder47.5
heart muscle49
kidney63.8
liver38.6
lung40.5
lymph node37.6
ovary68
pancreas21.2
placenta50.2
prostate53.7
salivary gland34.8
skin34
small intestine59.4
spleen43.5
stomach41.6
testis93.6
thyroid gland64.1
urinary bladder57
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*166945, gene) Neighbor of brca1 gene 1; NBR1OMIM


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