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> Protein (NX_Q14653)
Protein (NX_Q14653)
Protein
Gene SymbolIRF3 to neXtProt (NX_Q14653)
DescriptionInterferon regulatory factor 3
Chromosome19
Location19q13.33 (50162826 ~ 50169132) to Ensembl
Sequene Features : Isoforms 5, Variants 72, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.programmed necrotic cell death
.macrophage apoptotic process
.cellular response to dsRNA
  + 28 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 72 19
2014-09-19protein level
5 60 19
2014-05-27protein level
5 59 6
2014-02-25protein level
5 59 6
2013-12-09protein level
5 43 5
2013-11-01protein level
5 40 4
2013-09-12protein level
5 40 5
2013-08-17protein level
4 36 5
2013-07-15protein level
2 23 5
2013-06-11protein level
2 23 5
2013-02-12protein level
2 18 9
2012-12-20protein level
2 18 9
2012-10-30protein level
2 18 9
2012-10-07protein level
2 18 5
2012-08-24protein level
2 13 5
2012-07-28protein level
2 13 5
2012-06-08protein level
2 27 5
2012-05-07protein level
2 26 5
2012-04-10protein level
1 26 5
2012-01-13protein level
1 21 5
2011-12-20protein level
1 21 5
2011-11-11protein level
1 21 5
2011-08-23protein level
1 21 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14653-1
1 15 0 47189.4783
NX_Q14653-2
0 9 0 33149.5627
NX_Q14653-3
1 5 0 16719.3715
NX_Q14653-4
5 12 0 49103.4086
NX_Q14653-5
3 1 0 12322.3552
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2650369,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-2650369,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
3 EBI-2650369,EBI-971402 RBL1  
  .regulation of cell cycle
.positive regulation of transcription from RNA polymerase II promoter
.regulation of lipid kinase activity
  + 8 more...
.transcription factor binding .transcription factor complex
.nucleoplasm
.nucleus
4 EBI-2650369,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
5 EBI-2650369,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
6 EBI-2650369,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
7 EBI-2650369,EBI-5349621 GRIP1  
  .positive regulation of transcription, DNA-templated
.intracellular signal transduction
.androgen receptor signaling pathway
  + 3 more...
.androgen receptor binding
.glucocorticoid receptor binding
.receptor signaling complex scaffold activity
  + 3 more...
.recycling endosome
.postsynaptic membrane
.membrane raft
  + 7 more...
8 EBI-2650369,EBI-3649340 MAFB  
  .thymus development
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of osteoclast differentiation
  + 10 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.transcription factor complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites100
bladder33
blood32
bone153
brain22
cervix41
connective tissue33
embryonic tissue75
esophagus49
eye19
heart78
intestine73
kidney23
liver24
lung44
lymph45
lymph node356
mammary gland66
mouth45
muscle65
ovary39
pancreas37
placenta74
prostate52
skin33
spleen374
stomach73
testis9
thymus426
trachea57
uterus68
Health State
TissuesTPM*
normal55
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor42
germ cell tumor11
glioma46
head and neck tumor7
kidney tumor29
leukemia10
liver tumor10
lung tumor19
lymphoma41
non-neoplasia31
pancreatic tumor66
primitive neuroectodermal tumor of the CNS7
prostate cancer28
skin tumor47
soft tissue/muscle tissue tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult43
embryoid body100
blastocyst81
fetus17
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28
adrenal gland28.7
appendix53.1
bone marrow33.3
cerebral cortex16.9
colon31.4
duodenum44.7
esophagus22.5
gallbladder40.2
heart muscle17.5
kidney25.5
liver22.2
lung44.4
lymph node79
ovary37
pancreas13.1
placenta32.6
prostate36.2
salivary gland36.7
skin56.2
small intestine43.7
spleen72.5
stomach44.2
testis20.7
thyroid gland29.6
urinary bladder35.6
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603734, gene) Interferon regulatory factor 3; IRF3OMIM


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