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> Protein (NX_Q14689)
Protein (NX_Q14689)
Protein
Gene SymbolDIP2A to neXtProt (NX_Q14689)
DescriptionDisco-interacting protein 2 homolog A
Chromosome21
Location21q22.3 (47878812 ~ 47989926) to Ensembl
Sequene Features : Isoforms 6, Variants 168, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 168 2
2014-09-19protein level
6 137 2
2014-05-27protein level
6 137 4
2014-02-25protein level
6 136 4
2013-12-09protein level
6 99 4
2013-11-01protein level
6 98 3
2013-09-12protein level
6 98 3
2013-08-17protein level
6 98 3
2013-07-15protein level
5 59 2
2013-06-11protein level
5 59 2
2013-02-12protein level
4 16 0
2012-12-20protein level
4 20 0
2012-10-30protein level
4 20 0
2012-10-07protein level
4 20 0
2012-08-24protein level
4 19 0
2012-07-28protein level
4 19 0
2012-06-08protein level
4 21 0
2012-05-07protein level
4 14 0
2012-04-10protein level
4 14 0
2012-01-13protein level
4 8 0
2011-12-20protein level
4 8 0
2011-11-11protein level
4 8 0
2011-08-23protein level
4 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14689-1
0 63 12 170260.6714
NX_Q14689-2
0 35 4 90538.5984
NX_Q14689-3
1 33 4 85959.4252
NX_Q14689-4
1 37 4 95940.3644
NX_Q14689-5
1 47 4 119391.6782
NX_Q14689-6
1 62 12 169808.4344
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10233719,EBI-740718 ZBTB43  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-10233719,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
3 EBI-2564275,EBI-779636 TGFB1  
  .positive regulation of transcription regulatory region DNA binding
.regulation of actin cytoskeleton reorganization
.positive regulation of NAD+ ADP-ribosyltransferase activity
  + 151 more...
.type III transforming growth factor beta receptor binding
.type I transforming growth factor beta receptor binding
.enzyme binding
  + 4 more...
.blood microparticle
.neuronal cell body
.platelet alpha granule lumen
  + 9 more...
4 EBI-2564275,EBI-1571188 FST  
  .positive regulation of hair follicle development
.negative regulation of cell differentiation
.keratinocyte proliferation
  + 10 more...
.activin binding
.signal transducer activity
.cytoplasm
.nucleus
.extracellular region
5 EBI-10233719,EBI-1047946 PTPN3  
  .regulation of sodium ion transmembrane transporter activity
.regulation of membrane depolarization during action potential
.liver regeneration
  + 4 more...
.ATPase binding
.sodium channel regulator activity
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
6 EBI-10233719,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
7 EBI-10233719,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
8 EBI-2564275,EBI-2349801 FSTL1  
  .response to starvation
.BMP signaling pathway
.heparin binding
.calcium ion binding
.extracellular exosome
.extracellular space
.extracellular region
9 EBI-2564275,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
10 EBI-10233719,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
11 EBI-2564275,EBI-745689 FAM214B  
  .N/A .N/A .nucleus
12 EBI-10233719,EBI-745680 STAC3  
  .skeletal muscle fiber development
.intracellular signal transduction
.neuromuscular synaptic transmission
.skeletal muscle contraction
.metal ion binding
.identical protein binding
.N/A
13 EBI-2564275,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
14 EBI-10233719,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
15 EBI-10233719,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
16 EBI-2564275,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder33
blood24
brain27
connective tissue13
embryonic tissue42
eye62
heart33
intestine47
kidney28
liver19
lung38
lymph node11
mammary gland33
mouth30
muscle37
nerve64
ovary9
pancreas42
pituitary gland60
placenta35
prostate58
skin18
spleen18
stomach114
testis27
thymus37
thyroid85
uterus43
vascular19
Health State
TissuesTPM*
normal32
breast (mammary gland) tumor32
chondrosarcoma12
colorectal tumor44
gastrointestinal tumor84
germ cell tumor22
glioma18
head and neck tumor44
kidney tumor43
leukemia42
liver tumor20
lung tumor9
lymphoma55
non-neoplasia31
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer28
retinoblastoma43
soft tissue/muscle tissue tumor95
uterine tumor44
Developmental Stage
TissuesTPM*
adult45
embryoid body42
blastocyst32
fetus26
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12
adrenal gland16.5
appendix17.5
bone marrow20.1
cerebral cortex15.4
colon14.1
duodenum14.5
esophagus10.5
gallbladder14.6
heart muscle13.5
kidney9.1
liver4.2
lung17.9
lymph node24.8
ovary17.7
pancreas6.5
placenta14.6
prostate22.5
salivary gland11.5
skin28.4
small intestine16.4
spleen27.8
stomach17.9
testis20.3
thyroid gland11.6
urinary bladder14.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607711, gene) Disco-interacting protein 2, drosophila, homolog of, a; DIP2AOMIM


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