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> Protein (NX_Q14781)
Protein (NX_Q14781)
Protein
Gene SymbolCBX2 to neXtProt (NX_Q14781)
DescriptionChromobox protein homolog 2
Chromosome17
Location17q25.3 (77751931 ~ 77761782) to Ensembl
Sequene Features : Isoforms 2, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.development of primary sexual characteristics
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.chromatin binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 75 2
2014-09-19protein level
2 65 2
2014-05-27protein level
2 65 2
2014-02-25protein level
2 65 0
2013-12-09protein level
2 34 0
2013-11-01protein level
2 29 0
2013-09-12protein level
2 29 0
2013-08-17protein level
2 29 0
2013-07-15protein level
2 23 0
2013-06-11protein level
2 23 0
2013-02-12protein level
2 11 0
2012-12-20protein level
2 12 0
2012-10-30protein level
2 16 0
2012-10-07protein level
2 16 0
2012-08-24protein level
2 16 0
2012-07-28protein level
2 16 0
2012-06-08protein level
2 17 0
2012-05-07protein level
2 15 0
2012-04-10protein level
2 15 0
2012-01-13protein level
2 7 0
2011-12-20protein level
2 7 0
2011-11-11protein level
2 7 0
2011-08-23protein level
2 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14781-1
23 3 0 56045.9026
NX_Q14781-2
4 3 0 23296.6229
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745934,EBI-10196781 KRTAP2-3  
  .N/A .N/A .keratin filament
2 EBI-745934,EBI-8638511 RBMY1A1  
  .RNA splicing
.mRNA processing
.regulation of alternative mRNA splicing, via spliceosome
.mRNA binding
.nucleotide binding
.nucleus
3 EBI-745934,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-745934,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
5 EBI-745934,EBI-8642021 RBMY1F  
  .RNA splicing
.spermatogenesis
.mRNA processing
.RNA binding
.nucleotide binding
.nucleus
6 EBI-745934,EBI-1051531 DHX57  
  .RNA processing .metal ion binding
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.mitochondrion
.nucleus
7 EBI-745934,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood16
bone13
brain10
connective tissue6
embryonic tissue93
eye38
heart22
intestine21
kidney18
liver4
lung29
lymph22
lymph node11
mammary gland19
muscle18
ovary29
pancreas4
placenta7
prostate5
skin4
spleen18
stomach20
testis13
uterus47
Health State
TissuesTPM*
normal13
breast (mammary gland) tumor32
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor25
germ cell tumor34
glioma74
kidney tumor43
leukemia21
lung tumor58
lymphoma13
non-neoplasia20
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS62
prostate cancer9
retinoblastoma107
skin tumor7
soft tissue/muscle tissue tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult9
embryoid body114
blastocyst146
fetus10
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
bone marrow1.9
esophagus1.5
heart muscle1.5
lung1.6
lymph node1.2
ovary2.3
placenta1.9
skin1.6
spleen1.5
testis10.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602770, gene) Chromobox homolog 2, drosophila polycomb class; CBX2OMIM
2(#613080, phenotype) 46,xy sex reversal 5; SRXY5OMIM


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