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> Protein (NX_Q14847)
Protein (NX_Q14847)
Protein
Gene SymbolLASP1 to neXtProt (NX_Q14847)
DescriptionLIM and SH3 domain protein 1
Chromosome17
Location17q12 (37026112 ~ 37078023) to Ensembl
Sequene Features : Isoforms 3, Variants 35, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 35 16
2014-09-19protein level
3 25 16
2014-05-27protein level
3 25 16
2014-02-25protein level
2 23 14
2013-12-09protein level
2 17 14
2013-11-01protein level
2 17 11
2013-09-12protein level
2 17 11
2013-08-17protein level
2 17 11
2013-07-15protein level
2 12 9
2013-06-11protein level
2 12 9
2013-02-12protein level
2 5 20
2012-12-20protein level
2 5 20
2012-10-30protein level
2 8 20
2012-10-07protein level
2 8 10
2012-08-24protein level
2 8 10
2012-07-28protein level
2 8 10
2012-06-08protein level
2 3 10
2012-05-07protein level
2 3 10
2012-04-10protein level
2 3 10
2012-01-13protein level
2 3 10
2011-12-20protein level
2 3 10
2011-11-11protein level
2 3 8
2011-08-23protein level
2 3 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14847-1
0 12 1 29698.1372
NX_Q14847-2
3 9 1 35990.6052
NX_Q14847-3
1 9 0 23167.1639
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742828,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-742828,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-742828,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-742828,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
5 EBI-742828,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
6 EBI-742828,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
7 EBI-742828,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
8 EBI-742828,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
9 EBI-742828,EBI-444225 ZYX  
  .regulation of inflammatory response
.stress fiber assembly
.viral process
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.focal adhesion
.cell-cell adherens junction
.integral component of plasma membrane
  + 4 more...
10 EBI-9088686,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
11 EBI-742828,EBI-718388 LPP  
  .cell adhesion .zinc ion binding .focal adhesion
.plasma membrane
.cytoplasm
.nucleus
12 EBI-742828,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
13 EBI-742828,EBI-5458880 ZC2HC1A  
  .N/A .metal ion binding .N/A
14 EBI-742828,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
15 EBI-742828,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
16 EBI-742828,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
17 EBI-742828,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
18 EBI-742828,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
19 EBI-742828,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
20 EBI-742828,EBI-1042602 TJP2  
  .regulation of membrane permeability
.establishment of endothelial intestinal barrier
.intestinal absorption
  + 6 more...
.protein binding, bridging
.protein domain specific binding
.guanylate kinase activity
.cell junction
.tight junction
.adherens junction
  + 4 more...
21 EBI-742828,EBI-727037 SEPT3  
  .cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland121
ascites225
bladder167
blood155
bone209
bone marrow307
brain341
cervix206
connective tissue194
ear62
embryonic tissue300
esophagus49
eye86
heart122
intestine331
kidney237
larynx127
liver204
lung200
lymph225
lymph node356
mammary gland224
mouth423
muscle84
nerve128
ovary147
pancreas276
pharynx49
placenta226
prostate100
salivary gland148
skin336
spleen168
stomach386
testis147
thymus652
thyroid322
tonsil293
trachea521
umbilical cord435
uterus353
vascular135
Health State
TissuesTPM*
normal209
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor279
cervical tumor289
chondrosarcoma265
colorectal tumor471
esophageal tumor57
gastrointestinal tumor388
germ cell tumor262
glioma149
head and neck tumor351
kidney tumor362
leukemia222
liver tumor333
lung tumor330
lymphoma235
non-neoplasia217
ovarian tumor118
pancreatic tumor371
primitive neuroectodermal tumor of the CNS78
prostate cancer173
retinoblastoma43
skin tumor303
soft tissue/muscle tissue tumor159
uterine tumor244
Developmental Stage
TissuesTPM*
adult164
embryoid body543
blastocyst195
neonate514
fetus231
infant170
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue66.1
adrenal gland25.1
appendix62.6
bone marrow68.8
cerebral cortex38.3
colon81.5
duodenum95.4
esophagus29.9
gallbladder55.9
heart muscle17.9
kidney43.3
liver33.9
lung59.4
lymph node63.5
ovary41.1
pancreas19.9
placenta58.7
prostate22.1
salivary gland25.9
skin34.1
small intestine122.1
spleen61.4
stomach75.7
testis21.1
thyroid gland23.1
urinary bladder53.6
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
breastMedium
bronchusLow
cerebellumLow
cerebral cortexMedium
colonHigh
duodenumHigh
endometrium 2Medium
gallbladderHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungHigh
lymph nodeHigh
nasopharynxLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaHigh
rectumHigh
salivary glandLow
small intestineHigh
spleenMedium
stomach 1Medium
stomach 2High
thyroid glandLow
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602920, gene) Lim and sh3 protein 1; LASP1OMIM
2acute myelogenous leukemiaCGP


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