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> Protein (NX_Q14934)
Protein (NX_Q14934)
Protein
Gene SymbolNFATC4 to neXtProt (NX_Q14934)
DescriptionNuclear factor of activated T-cells, cytoplasmic 4
Chromosome14
Location14q12 (24834879 ~ 24848810) to Ensembl
Sequene Features : Isoforms 24, Variants 122, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.cellular response to lithium ion
.muscle cell development
  + 11 more...
.transcription coactivator activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.intermediate filament cytoskeleton
.cytosol
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
24 122 8
2014-09-19protein level
24 75 8
2014-05-27protein level
24 75 8
2014-02-25protein level
24 75 8
2013-12-09protein level
24 56 7
2013-11-01protein level
24 56 7
2013-09-12protein level
24 56 7
2013-08-17protein level
24 56 7
2013-07-15protein level
24 45 7
2013-06-11protein level
24 45 7
2013-02-12protein level
24 24 126
2012-12-20protein level
24 25 126
2012-10-30protein level
24 26 126
2012-10-07protein level
24 26 7
2012-08-24protein level
24 26 7
2012-07-28protein level
24 26 7
2012-06-08protein level
24 9 7
2012-05-07protein level
24 9 7
2012-04-10protein level
24 9 7
2012-01-13protein level
24 9 7
2011-12-20protein level
24 10 7
2011-11-11protein level
24 10 7
2011-08-23protein level
24 10 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14934-1
0 40 1 95389.0805
NX_Q14934-10
0 38 1 93919.2252
NX_Q14934-11
0 38 1 90468.7855
NX_Q14934-12
0 38 1 88214.65
NX_Q14934-13
0 37 1 88047.3278
NX_Q14934-14
0 37 1 87227.0713
NX_Q14934-15
0 36 1 85454.2211
NX_Q14934-16
0 36 1 84241.6325
NX_Q14934-17
0 35 1 82939.0994
NX_Q14934-18
0 34 1 77067.202
NX_Q14934-19
0 19 0 47343.5818
NX_Q14934-2
0 42 1 101616.2335
NX_Q14934-20
0 18 0 47176.2596
NX_Q14934-21
0 15 0 36196.1338
NX_Q14934-22
0 7 0 20091.6369
NX_Q14934-23
0 6 0 19924.3147
NX_Q14934-24
0 3 0 8944.1889
NX_Q14934-3
0 41 1 101448.9113
NX_Q14934-4
0 41 1 98374.5193
NX_Q14934-5
0 40 1 98207.1971
NX_Q14934-6
0 40 1 96601.6691
NX_Q14934-7
0 39 1 96434.3469
NX_Q14934-8
0 39 1 95221.7583
NX_Q14934-9
0 39 1 94086.5474
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3905796,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites75
bone167
brain86
connective tissue107
embryonic tissue46
eye47
heart145
intestine25
kidney52
liver4
lung53
lymph node11
mammary gland26
mouth166
muscle56
nerve64
ovary137
pancreas18
pituitary gland60
placenta158
prostate10
salivary gland98
skin113
spleen18
stomach20
testis137
thymus62
thyroid85
trachea540
umbilical cord145
uterus327
vascular58
Health State
TissuesTPM*
normal80
adrenal tumor158
breast (mammary gland) tumor21
chondrosarcoma96
colorectal tumor8
gastrointestinal tumor33
germ cell tumor98
glioma46
head and neck tumor127
kidney tumor29
non-neoplasia51
ovarian tumor131
pancreatic tumor28
primitive neuroectodermal tumor of the CNS196
retinoblastoma21
skin tumor63
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult67
embryoid body71
blastocyst48
neonate354
fetus98
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.3
adrenal gland39.8
appendix15.2
bone marrow1.7
cerebral cortex6.5
colon12.8
duodenum9.6
esophagus17.7
gallbladder49.5
heart muscle15.8
kidney9.2
liver1.9
lung19.4
lymph node12.1
ovary65.2
pancreas4.4
placenta38
prostate20.4
salivary gland8.6
skin24
small intestine12.7
spleen9.5
stomach12
testis29.7
thyroid gland13.4
urinary bladder34.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602699, gene) Nuclear factor of activated t cells, cytoplasmic, calcineurin-dependentOMIM


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