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> Protein (NX_Q14974)
Protein (NX_Q14974)
Protein
Gene SymbolKPNB1 to neXtProt (NX_Q14974)
DescriptionImportin subunit beta-1
Chromosome17
Location17q21.32 (45726842 ~ 45762871) to Ensembl
Sequene Features : Isoforms 2, Variants 74, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular transport of virus
.small molecule metabolic process
.cytokine-mediated signaling pathway
  + 10 more...
.poly(A) RNA binding
.protein domain specific binding
.enzyme binding
  + 3 more...
.endoplasmic reticulum tubular network
.extracellular exosome
.nuclear membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 74 17
2014-09-19protein level
2 47 17
2014-05-27protein level
2 46 18
2014-02-25protein level
1 47 18
2013-12-09protein level
1 41 18
2013-11-01protein level
1 39 11
2013-09-12protein level
1 39 11
2013-08-17protein level
1 39 12
2013-07-15protein level
1 24 9
2013-06-11protein level
1 24 9
2013-02-12protein level
1 6 7
2012-12-20protein level
1 6 7
2012-10-30protein level
1 6 7
2012-10-07protein level
1 6 7
2012-08-24protein level
1 4 7
2012-07-28protein level
1 4 7
2012-06-08protein level
1 9 7
2012-05-07protein level
1 7 7
2012-04-10protein level
1 7 7
2012-01-13protein level
1 12 7
2011-12-20protein level
1 12 7
2011-11-11protein level
1 12 7
2011-08-23protein level
1 12 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14974-1
7 34 0 97107.7407
NX_Q14974-2
0 34 0 81126.4238
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286758,EBI-1052641 SMNDC1  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding .intermediate filament cytoskeleton
.nuclear speck
.Cajal body
  + 4 more...
2 EBI-286758,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-286758,EBI-395447 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites326
bladder167
blood212
bone195
bone marrow369
brain153
cervix639
connective tissue154
ear124
embryonic tissue465
esophagus198
eye268
heart134
intestine349
kidney241
larynx170
liver185
lung179
lymph722
lymph node211
mammary gland277
mouth710
muscle1043
nerve193
ovary295
pancreas103
pharynx171
placenta272
prostate422
salivary gland296
skin706
spleen280
stomach114
testis250
thymus238
thyroid300
tonsil235
trachea231
umbilical cord653
uterus361
vascular271
Health State
TissuesTPM*
normal173
adrenal tumor158
bladder carcinoma284
breast (mammary gland) tumor300
cervical tumor840
chondrosarcoma169
colorectal tumor222
esophageal tumor173
gastrointestinal tumor270
germ cell tumor493
glioma130
head and neck tumor485
kidney tumor421
leukemia275
liver tumor281
lung tumor340
lymphoma457
non-neoplasia134
ovarian tumor328
pancreatic tumor209
primitive neuroectodermal tumor of the CNS480
prostate cancer510
retinoblastoma646
skin tumor877
soft tissue/muscle tissue tumor1293
uterine tumor166
Developmental Stage
TissuesTPM*
adult216
embryoid body528
blastocyst504
neonate225
fetus157
infant127
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue88
adrenal gland63.9
appendix125.5
bone marrow44.4
cerebral cortex66.2
colon74.3
duodenum57.4
esophagus96.5
gallbladder71.1
heart muscle64
kidney56.5
liver53.9
lung59
lymph node133.9
ovary93.2
pancreas39.9
placenta79.3
prostate63.7
salivary gland49.3
skin47.1
small intestine55
spleen87.6
stomach70.1
testis154.3
thyroid gland86.8
urinary bladder102.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602738, gene) Karyopherin beta-1; KPNB1OMIM


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