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> Protein (NX_Q14BN4)
Protein (NX_Q14BN4)
Protein
Gene SymbolSLMAP to neXtProt (NX_Q14BN4)
DescriptionSarcolemmal membrane-associated protein
Chromosome3
Location3p14.3 (57741177 ~ 57914895) to Ensembl
Sequene Features : Isoforms 8, Variants 71, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.muscle contraction .N/A .sarcolemma
.integral component of plasma membrane
.microtubule organizing center
.smooth endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 71 4
2014-09-19protein level
8 47 4
2014-05-27protein level
8 47 4
2014-02-25protein level
8 47 4
2013-12-09protein level
8 31 4
2013-11-01protein level
8 26 4
2013-09-12protein level
8 26 4
2013-08-17protein level
8 26 4
2013-07-15protein level
8 21 4
2013-06-11protein level
8 21 4
2013-02-12protein level
8 8 15
2012-12-20protein level
8 8 15
2012-10-30protein level
8 15 15
2012-10-07protein level
8 15 3
2012-08-24protein level
8 15 3
2012-07-28protein level
8 14 3
2012-06-08protein level
8 3 3
2012-05-07protein level
8 3 3
2012-04-10protein level
8 3 3
2012-01-13protein level
8 3 3
2011-12-20protein level
8 3 3
2011-11-11protein level
8 3 3
2011-08-23protein level
8 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q14BN4-1
1 41 0 95139.3315
NX_Q14BN4-2
0 40 0 90773.1415
NX_Q14BN4-3
1 41 0 93145.2755
NX_Q14BN4-4
4 21 0 52195.7342
NX_Q14BN4-5
1 19 0 41870.5289
NX_Q14BN4-6
2 21 0 57495.013
NX_Q14BN4-7
2 18 0 49146.7251
NX_Q14BN4-8
1 13 0 31418.1982
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1043216,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-1043216,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
3 EBI-1043216,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood49
bone13
bone marrow82
brain16
cervix41
connective tissue20
embryonic tissue18
eye38
heart178
intestine73
kidney66
larynx85
liver4
lung38
lymph22
lymph node111
mammary gland6
muscle112
nerve64
ovary9
pancreas51
parathyroid194
pharynx49
placenta28
prostate58
skin56
stomach62
testis78
thymus75
thyroid64
trachea173
umbilical cord72
uterus133
vascular425
Health State
TissuesTPM*
normal59
cervical tumor28
chondrosarcoma36
colorectal tumor71
gastrointestinal tumor50
germ cell tumor34
glioma9
head and neck tumor7
kidney tumor14
leukemia63
lung tumor19
lymphoma27
non-neoplasia31
ovarian tumor13
prostate cancer48
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult43
embryoid body28
neonate32
fetus55
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.8
adrenal gland38.8
appendix43.9
bone marrow22.9
cerebral cortex18.2
colon46.5
duodenum33
esophagus127
gallbladder44.5
heart muscle186.6
kidney27.1
liver13
lung22.8
lymph node21.6
ovary42
pancreas9.3
placenta22.5
prostate76.7
salivary gland17.8
skin20.6
small intestine35.8
spleen16.7
stomach27.7
testis50.9
thyroid gland37.7
urinary bladder90.8
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowMedium
cerebellumHigh
cerebral cortexMedium
colonMedium
duodenumLow
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderLow
heart muscleHigh
hippocampusLow
lymph nodeLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
salivary glandLow
seminal vesicleHigh
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineLow
smooth muscleHigh
stomach 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602701, gene) Sarcolemmal-associated protein; SLMAPOMIM


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