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> Protein (NX_Q15013)
Protein (NX_Q15013)
Protein
Gene SymbolMAD2L1BP to neXtProt (NX_Q15013)
DescriptionMAD2L1-binding protein
Chromosome6
Location6p21.1 (43597277 ~ 43608689) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of exit from mitosis
.mitotic cell cycle checkpoint
.N/A .intracellular membrane-bounded organelle
.spindle
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 3
2014-09-19protein level
2 19 3
2014-05-27protein level
2 19 3
2014-02-25protein level
2 19 3
2013-12-09protein level
2 11 3
2013-11-01protein level
2 10 3
2013-09-12protein level
2 10 3
2013-08-17protein level
2 10 3
2013-07-15protein level
2 6 1
2013-06-11protein level
2 6 1
2013-02-12protein level
1 4 2
2012-12-20protein level
1 4 2
2012-10-30protein level
1 2 2
2012-10-07protein level
1 2 2
2012-08-24protein level
1 2 2
2012-07-28protein level
1 2 2
2012-06-08protein level
1 6 2
2012-05-07protein level
1 5 2
2012-04-10protein level
1 5 2
2012-01-13protein level
1 5 2
2011-12-20protein level
1 5 2
2011-11-11protein level
1 5 2
2011-08-23protein level
1 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15013-1
1 12 0 31031.4884
NX_Q15013-3
2 12 0 34653.3697
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712181,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-712181,EBI-78203 MAD2L1  
  .positive regulation of mitotic cell cycle spindle assembly checkpoint
.negative regulation of APC-Cdc20 complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 11 more...
.protein homodimerization activity
.identical protein binding
.mitotic spindle
.perinuclear region of cytoplasm
.cytosol
  + 4 more...
3 EBI-712181,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
4 EBI-712181,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
5 EBI-712181,EBI-989213 SGOL2  
  .meiotic sister chromatid cohesion, centromeric
.cell division
.small GTPase mediated signal transduction
.mitotic cell cycle
.N/A .mitotic cohesin complex
.cytosol
.nucleoplasm
  + 2 more...
6 EBI-712181,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
7 EBI-712181,EBI-749162 INPP5K  
  .positive regulation of renal water transport
.negative regulation of glycogen (starch) synthase activity
.ruffle assembly
  + 35 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.inositol trisphosphate phosphatase activity
  + 7 more...
.perinuclear region of cytoplasm
.neuron projection
.ruffle membrane
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
blood32
bone69
bone marrow20
brain10
cervix41
connective tissue20
embryonic tissue37
eye90
heart11
intestine60
kidney18
liver14
lung41
lymph22
lymph node55
mammary gland46
muscle9
ovary29
pancreas32
parathyroid194
pharynx147
placenta102
prostate26
salivary gland49
skin113
spleen18
stomach41
testis4
thymus12
uterus30
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma48
colorectal tumor71
gastrointestinal tumor67
germ cell tumor30
glioma37
head and neck tumor7
leukemia63
lung tumor38
lymphoma27
non-neoplasia10
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma107
skin tumor111
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult36
embryoid body14
blastocyst65
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland12.6
appendix14.7
bone marrow37.5
cerebral cortex13.2
colon23.3
duodenum22.4
esophagus14.8
gallbladder16.1
heart muscle19.7
kidney13.7
liver9.9
lung14.1
lymph node21.8
ovary12.5
pancreas7.6
placenta12.8
prostate12.1
salivary gland16.8
skin11
small intestine16.8
spleen11.8
stomach15.8
testis15.3
thyroid gland14.9
urinary bladder21.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)


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