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> Protein (NX_Q15025)
Protein (NX_Q15025)
Protein
Gene SymbolTNIP1 to neXtProt (NX_Q15025)
DescriptionTNFAIP3-interacting protein 1
Chromosome5
Location5q33.1 (150409506 ~ 150473138) to Ensembl
Sequene Features : Isoforms 8, Variants 85, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 85 9
2014-09-19protein level
8 71 9
2014-05-27protein level
3 69 9
2014-02-25protein level
3 69 8
2013-12-09protein level
3 59 8
2013-11-01protein level
3 57 8
2013-09-12protein level
3 57 8
2013-08-17protein level
3 57 8
2013-07-15protein level
3 43 8
2013-06-11protein level
3 43 8
2013-02-12protein level
3 30 16
2012-12-20protein level
2 30 12
2012-10-30protein level
2 28 12
2012-10-07protein level
2 28 6
2012-08-24protein level
2 23 6
2012-07-28protein level
2 23 6
2012-06-08protein level
2 23 5
2012-05-07protein level
2 23 5
2012-04-10protein level
2 23 5
2012-01-13protein level
2 19 5
2011-12-20protein level
2 19 5
2011-11-11protein level
2 19 3
2011-08-23protein level
2 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15025-1
0 24 0 71819.3783
NX_Q15025-2
0 24 0 71743.435
NX_Q15025-3
0 22 0 65970.4611
NX_Q15025-4
0 22 0 64459.9424
NX_Q15025-5
1 20 0 62570.169
NX_Q15025-6
0 22 0 64383.9991
NX_Q15025-7
0 20 0 61531.7466
NX_Q15025-8
2 20 0 62064.8585
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-357849,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-357849,EBI-347522 ZNHIT1  
  .negative regulation of G0 to G1 transition
.histone exchange
.regulation of T cell proliferation
  + 2 more...
.metal ion binding
.histone deacetylase binding
.nucleosome binding
.nucleus
.Swr1 complex
3 EBI-357849,EBI-527670 TNFAIP3  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of CD40 signaling pathway
.positive regulation of hepatocyte proliferation
  + 46 more...
.protein self-association
.ubiquitin binding
.ligase activity
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
4 EBI-357849,EBI-739899 ZBTB25  
  .gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
5 EBI-357849,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
6 EBI-357849,EBI-3905829 CCNG1  
  .cell division
.negative regulation of apoptotic process
.cell growth
  + 6 more...
.N/A .perinuclear region of cytoplasm
.neuronal cell body
.dendrite
.nucleus
7 EBI-357849,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
8 EBI-357849,EBI-389564 GTF2B  
  .viral process
.gene expression
.transcription elongation from RNA polymerase II promoter
  + 3 more...
.thyroid hormone receptor binding
.zinc ion binding
.transcription factor binding
.core promoter binding
.nucleolus
.nucleoplasm
.nucleus
9 EBI-357849,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
10 EBI-357849,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
11 EBI-357849,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
12 EBI-357849,EBI-1046878 GIT2  
  .behavioral response to pain
.regulation of G-protein coupled receptor protein signaling pathway
.zinc ion binding
.GTPase activator activity
.focal adhesion
.nucleoplasm
13 EBI-357849,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
14 EBI-357849,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
15 EBI-357849,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
16 EBI-357849,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
17 EBI-357849,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
18 EBI-357849,EBI-9679267 MOB3C  
  .N/A .metal ion binding .N/A
19 EBI-357849,EBI-2558745 MOB1B  
  .protein autophosphorylation
.positive regulation of phosphorylation
.hippo signaling
.metal ion binding
.kinase binding
.kinase activator activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleus
20 EBI-357849,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
21 EBI-357849,EBI-750003 HDDC3  
  .N/A .metal ion binding
.guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
.N/A
22 EBI-357849,EBI-745040 CCDC112  
  .N/A .N/A .N/A
23 EBI-357849,EBI-749336 SNIP1  
  .positive regulation of protein targeting to mitochondrion
.production of miRNAs involved in gene silencing by miRNA
.I-kappaB kinase/NF-kappaB signaling
.regulation of transcription, DNA-templated
.poly(A) RNA binding .cytoplasm
.nucleoplasm
24 EBI-357849,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
25 EBI-357849,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
26 EBI-357849,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
27 EBI-357849,EBI-741835 MAGEB18  
  .N/A .N/A .cytoplasm
28 EBI-357849,EBI-742422 CFAP53  
  .N/A .N/A .cilium
29 EBI-357849,EBI-5462748 TCEANC2  
  .transcription, DNA-templated .DNA binding .nucleus
30 EBI-357849,EBI-1045072 PNKP  
  .polynucleotide 3' dephosphorylation
.DNA 3' dephosphorylation involved in DNA repair
.nucleic acid phosphodiester bond hydrolysis
  + 9 more...
.ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
.polynucleotide 3'-phosphatase activity
.nucleotide kinase activity
  + 5 more...
.membrane
.nucleolus
.nucleoplasm
.nucleus
31 EBI-357849,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
32 EBI-357849,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
33 EBI-357849,EBI-2561019 NIFK  
  .rRNA metabolic process
.negative regulation of phosphatase activity
.rRNA transcription
.protein complex assembly
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleolus
.nucleoplasm
  + 2 more...
34 EBI-357849,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
35 EBI-357849,EBI-3464833 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
36 EBI-357849,EBI-473834 MAGEH1  
  .apoptotic process .N/A .cytoplasm
37 EBI-357849,EBI-749072 VPS33B  
  .platelet alpha granule organization
.membrane fusion
.lysosome localization
  + 4 more...
.N/A .perinuclear region of cytoplasm
.late endosome membrane
.platelet alpha granule
  + 4 more...
38 EBI-357849,EBI-2876678 CDIP1  
  .intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.tumor necrosis factor-mediated signaling pathway
.apoptotic process
.N/A .nucleus
39 EBI-357849,EBI-720768 MAP1LC3A  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.phosphatidylethanolamine binding
.microtubule binding
.phospholipid binding
.cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
40 EBI-357849,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
41 EBI-357849,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
42 EBI-357849,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites125
bladder167
blood253
bone97
bone marrow41
brain59
cervix82
connective tissue93
embryonic tissue23
esophagus49
eye100
heart44
intestine146
kidney175
liver92
lung182
lymph474
lymph node22
mammary gland158
mouth15
muscle47
nerve64
ovary78
pancreas201
parathyroid97
pharynx49
pituitary gland60
placenta109
prostate63
salivary gland345
skin123
spleen337
stomach135
testis39
thymus87
trachea19
uterus8
vascular38
Health State
TissuesTPM*
normal83
bladder carcinoma113
breast (mammary gland) tumor150
cervical tumor86
chondrosarcoma156
colorectal tumor124
esophageal tumor57
gastrointestinal tumor101
germ cell tumor72
glioma167
head and neck tumor82
kidney tumor304
leukemia116
liver tumor187
lung tumor291
lymphoma318
non-neoplasia62
ovarian tumor105
pancreatic tumor333
primitive neuroectodermal tumor of the CNS55
prostate cancer86
retinoblastoma43
skin tumor79
soft tissue/muscle tissue tumor39
uterine tumor155
Developmental Stage
TissuesTPM*
adult8
embryoid body57
blastocyst16
neonate32
fetus7
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue97.7
adrenal gland30.1
appendix70.1
bone marrow78.1
cerebral cortex18.7
colon59.8
duodenum59.5
esophagus57.1
gallbladder57.1
heart muscle56.4
kidney58.5
liver41.7
lung53.3
lymph node62.4
ovary32.7
pancreas28.6
placenta30
prostate32.2
salivary gland34.3
skin30.9
small intestine66.8
spleen90.5
stomach61.3
testis17.3
thyroid gland36.6
urinary bladder48.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607714, gene) Tnfaip3-interacting protein 1; TNIP1OMIM


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