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> Protein (NX_Q15029)
Protein (NX_Q15029)
Protein
Gene SymbolEFTUD2 to neXtProt (NX_Q15029)
Description116 kDa U5 small nuclear ribonucleoprotein component
Chromosome17
Location17q21.31 (42927311 ~ 42977030) to Ensembl
Sequene Features : Isoforms 3, Variants 98, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.GTP binding
.GTPase activity
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 98 9
2014-09-19protein level
3 70 9
2014-05-27protein level
2 70 9
2014-02-25protein level
2 69 9
2013-12-09protein level
2 61 9
2013-11-01protein level
2 59 6
2013-09-12protein level
2 59 6
2013-08-17protein level
2 59 6
2013-07-15protein level
2 37 5
2013-06-11protein level
2 37 5
2013-02-12protein level
2 15 9
2012-12-20protein level
2 15 9
2012-10-30protein level
2 16 9
2012-10-07protein level
2 16 6
2012-08-24protein level
1 8 6
2012-07-28protein level
1 8 6
2012-06-08protein level
1 9 6
2012-05-07protein level
1 6 6
2012-04-10protein level
1 6 6
2012-01-13protein level
1 7 6
2011-12-20protein level
1 7 6
2011-11-11protein level
1 7 6
2011-08-23protein level
1 7 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15029-1
0 52 1 109365.9744
NX_Q15029-2
1 50 1 105316.3202
NX_Q15029-3
0 51 1 108214.4782
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-357897,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
2 EBI-357897,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
3 EBI-357897,EBI-713456 IK  
  .cell-cell signaling
.immune response
.identical protein binding .nucleolus
.nucleoplasm
.extracellular space
4 EBI-357897,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
5 EBI-357897,EBI-538479 PRPF8  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.pre-mRNA intronic binding
.K63-linked polyubiquitin binding
.poly(A) RNA binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites426
bladder66
blood229
bone97
bone marrow41
brain238
cervix329
connective tissue154
embryonic tissue234
esophagus99
eye167
heart122
intestine150
kidney218
larynx213
liver107
lung292
lymph474
lymph node200
mammary gland145
mouth665
muscle84
ovary216
pancreas107
pharynx73
placenta158
prostate131
salivary gland246
skin298
spleen243
stomach94
testis312
thymus414
thyroid171
tonsil117
trachea444
umbilical cord1017
uterus180
vascular116
Health State
TissuesTPM*
normal156
adrenal tumor237
breast (mammary gland) tumor128
cervical tumor463
chondrosarcoma120
colorectal tumor168
esophageal tumor115
gastrointestinal tumor312
germ cell tumor353
glioma83
head and neck tumor425
kidney tumor406
leukemia232
liver tumor187
lung tumor486
lymphoma346
non-neoplasia175
ovarian tumor249
pancreatic tumor142
primitive neuroectodermal tumor of the CNS291
prostate cancer202
retinoblastoma344
skin tumor382
soft tissue/muscle tissue tumor175
uterine tumor144
Developmental Stage
TissuesTPM*
adult130
embryoid body228
blastocyst325
neonate257
fetus244
infant127
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.8
adrenal gland25.7
appendix46.2
bone marrow46.8
cerebral cortex34.2
colon35.2
duodenum29.1
esophagus29.5
gallbladder24.1
heart muscle22.9
kidney26.7
liver21.3
lung27.2
lymph node46.8
ovary24.2
pancreas11.6
placenta32.4
prostate19.7
salivary gland15.1
skin29.5
small intestine26.5
spleen36
stomach27.1
testis40.4
thyroid gland32.6
urinary bladder30.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603892, gene) Elongation factor tu gtp-binding domain-containing 2; EFTUD2OMIM
2(#610536, phenotype) Mandibulofacial dysostosis with microcephaly; MFDMOMIM


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