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> Protein (NX_Q15038)
Protein (NX_Q15038)
Protein
Gene SymbolDAZAP2 to neXtProt (NX_Q15038)
DescriptionDAZ-associated protein 2
Chromosome12
Location12q13.13 (51632076 ~ 51665146) to Ensembl
Sequene Features : Isoforms 6, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .WW domain binding .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 27 1
2014-09-19protein level
6 14 1
2014-05-27protein level
5 14 1
2014-02-25protein level
5 14 1
2013-12-09protein level
5 8 1
2013-11-01protein level
5 8 1
2013-09-12protein level
5 8 1
2013-08-17protein level
5 8 1
2013-07-15protein level
4 7 0
2013-06-11protein level
4 7 0
2013-02-12protein level
2 4 0
2012-12-20protein level
2 5 0
2012-10-30protein level
2 5 0
2012-10-07protein level
2 5 0
2012-08-24protein level
2 5 0
2012-07-28protein level
2 5 0
2012-06-08protein level
2 6 0
2012-05-07protein level
2 5 0
2012-04-10protein level
2 5 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15038-1
0 3 0 17307.4609
NX_Q15038-2
2 1 0 16176.7697
NX_Q15038-3
1 2 0 13977.7971
NX_Q15038-4
1 1 0 9161.3893
NX_Q15038-5
7 0 0 22808.076
NX_Q15038-6
1 2 0 15163.3692
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724310,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-724310,EBI-473886 HIP1  
  .apoptotic signaling pathway
.clathrin-mediated endocytosis
.clathrin coat assembly
  + 7 more...
.phosphatidylinositol binding
.clathrin binding
.structural constituent of cytoskeleton
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
.clathrin-coated vesicle
  + 5 more...
3 EBI-724310,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
4 EBI-724310,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
5 EBI-724310,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
6 EBI-724310,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
7 EBI-724310,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
8 EBI-724310,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
9 EBI-724310,EBI-741277 USP5  
  .protein K48-linked deubiquitination
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.ubiquitin-dependent protein catabolic process
.zinc ion binding
.omega peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.lysosome
10 EBI-724310,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
11 EBI-724310,EBI-2105393 UBASH3A  
  .negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
12 EBI-724310,EBI-357375 RPS27A  
  .programmed necrotic cell death
.apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
  + 90 more...
.metal ion binding
.poly(A) RNA binding
.structural constituent of ribosome
.extracellular exosome
.endocytic vesicle membrane
.cytosolic small ribosomal subunit
  + 8 more...
13 EBI-724310,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
14 EBI-724310,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
15 EBI-724310,EBI-1048945 KRTAP19-5  
  .N/A .N/A .intermediate filament
16 EBI-724310,EBI-946029 C1orf94  
  .N/A .N/A .N/A
17 EBI-724310,EBI-10254232 VHLL  
  .cellular response to hypoxia
.protein ubiquitination
.N/A .nucleus
18 EBI-724310,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
19 EBI-724310,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
20 EBI-724310,EBI-10261141 KRTAP8-1  
  .N/A .N/A .intermediate filament
21 EBI-724310,EBI-742695 BATF2  
  .myeloid dendritic cell differentiation
.defense response to protozoan
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleus
22 EBI-724310,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
23 EBI-724310,EBI-2822515 SMAP2  
  .N/A .zinc ion binding
.GTPase activator activity
.cytoplasm
.nucleoplasm
24 EBI-724310,EBI-747823 ZFAND2B  
  .SRP-dependent cotranslational protein targeting to membrane, translocation .zinc ion binding .endoplasmic reticulum
25 EBI-724310,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
26 EBI-724310,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
27 EBI-724310,EBI-750730 OTULIN  
  .protein linear deubiquitination
.nucleotide-binding oligomerization domain containing 2 signaling pathway
.canonical Wnt signaling pathway
  + 4 more...
.cysteine-type peptidase activity
.ubiquitin-specific protease activity
.LUBAC complex
.cytoplasm
28 EBI-724310,EBI-373552 PLEKHB2  
  .N/A .N/A .recycling endosome membrane
29 EBI-724310,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
30 EBI-724310,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
31 EBI-724310,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
32 EBI-724310,EBI-743976 TEX37  
  .N/A .N/A .nucleus
33 EBI-724310,EBI-2129763 UBE2E2  
  .positive regulation of G1/S transition of mitotic cell cycle
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 3 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.N/A
34 EBI-724310,EBI-717962 NEDD4L  
  .positive regulation of caveolin-mediated endocytosis
.positive regulation of cation channel activity
.regulation of tight junction assembly
  + 39 more...
.ion channel binding
.sodium channel inhibitor activity
.potassium channel inhibitor activity
  + 4 more...
.extracellular exosome
.cytosol
.cytoplasm
  + 3 more...
35 EBI-724310,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
36 EBI-724310,EBI-749370 UBAC1  
  .protein ubiquitination .N/A .extracellular exosome
.plasma membrane
.Golgi apparatus
.cytoplasm
37 EBI-724310,EBI-74615 TOLLIP  
  .leukocyte activation
.innate immune response
.protein localization to endosome
  + 8 more...
.Toll-like receptor binding
.kinase binding
.signal transducer activity
.extracellular exosome
.perinuclear region of cytoplasm
.interleukin-1 receptor complex
  + 4 more...
38 EBI-724310,EBI-751555 RNF208  
  .protein autoubiquitination .zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleoplasm
39 EBI-724310,EBI-750745 EXD3  
  .N/A .N/A .N/A
40 EBI-724310,EBI-724639 PEF1  
  .response to calcium ion
.proteolysis
.protein dimerization activity
.protein heterodimerization activity
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.cytoplasm
41 EBI-724310,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
42 EBI-724310,EBI-741774 POLI  
  .error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA replication
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
.intracellular
43 EBI-724310,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
44 EBI-724310,EBI-2129242 RNF115  
  .protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytosol
45 EBI-724310,EBI-713198 EPN1  
  .embryonic organ development
.negative regulation of epidermal growth factor receptor signaling pathway
.female pregnancy
  + 4 more...
.lipid binding .coated pit
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland516
ascites376
bladder1071
blood1104
bone237
bone marrow430
brain446
cervix453
connective tissue281
embryonic tissue112
esophagus645
eye220
heart379
intestine418
kidney374
larynx85
liver204
lung385
lymph293
lymph node334
mammary gland449
mouth90
muscle206
nerve193
ovary157
pancreas238
parathyroid631
pharynx3093
pituitary gland181
placenta219
prostate337
salivary gland542
skin189
spleen1161
stomach428
testis211
thymus401
thyroid236
tonsil1880
trachea308
uterus499
vascular96
Health State
TissuesTPM*
normal396
adrenal tumor632
bladder carcinoma511
breast (mammary gland) tumor429
cervical tumor376
chondrosarcoma241
colorectal tumor284
esophageal tumor579
gastrointestinal tumor337
germ cell tumor201
glioma373
head and neck tumor164
kidney tumor348
leukemia349
liver tumor343
lung tumor398
lymphoma304
non-neoplasia641
ovarian tumor183
pancreatic tumor323
primitive neuroectodermal tumor of the CNS401
prostate cancer327
retinoblastoma301
skin tumor207
soft tissue/muscle tissue tumor383
uterine tumor477
Developmental Stage
TissuesTPM*
adult262
embryoid body100
blastocyst48
neonate257
fetus224
infant893
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue167.9
adrenal gland170.8
appendix259.5
bone marrow552.5
cerebral cortex178.4
colon263.6
duodenum241.1
esophagus209.7
gallbladder308.6
heart muscle268.7
kidney275.3
liver135.9
lung265.9
lymph node340.5
ovary176.3
pancreas87.1
placenta121.8
prostate186.3
salivary gland167.8
skin160.3
small intestine263
spleen294
stomach221.3
testis91.4
thyroid gland358.8
urinary bladder326.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*607431, gene) Daz-associated protein 2; DAZAP2OMIM


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