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> Protein (NX_Q15040)
Protein (NX_Q15040)
Protein
Gene SymbolJOSD1 to neXtProt (NX_Q15040)
DescriptionJosephin-1
Chromosome22
Location22q13.1 (39081548 ~ 39097561) to Ensembl
Sequene Features : Isoforms 1, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 21 3
2014-09-19protein level
1 16 3
2014-05-27protein level
1 16 3
2014-02-25protein level
1 16 3
2013-12-09protein level
1 10 3
2013-11-01protein level
1 10 2
2013-09-12protein level
1 10 2
2013-08-17protein level
1 10 2
2013-07-15protein level
1 4 1
2013-06-11protein level
1 4 1
2013-02-12protein level
1 2 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15040-1
10 0 0 23182.7654
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2510602,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-2510602,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
3 EBI-2510602,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
4 EBI-2510602,EBI-10178153 KRTAP10-4  
  .N/A .N/A .keratin filament
5 EBI-2510602,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-2510602,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
7 EBI-2510602,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-2510602,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-2510602,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
10 EBI-2510602,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
11 EBI-2510602,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland151
ascites150
bladder200
blood32
bone41
bone marrow41
brain45
cervix103
connective tissue60
embryonic tissue46
esophagus49
eye57
heart67
intestine99
kidney71
larynx42
liver24
lung77
lymph node55
mammary gland105
muscle18
ovary29
pancreas23
pharynx24
placenta14
prostate31
salivary gland197
skin56
spleen74
stomach104
testis50
thyroid64
umbilical cord145
uterus68
vascular58
Health State
TissuesTPM*
normal57
adrenal tumor237
bladder carcinoma284
breast (mammary gland) tumor75
cervical tumor144
chondrosarcoma48
colorectal tumor53
esophageal tumor57
gastrointestinal tumor109
germ cell tumor53
glioma74
head and neck tumor44
kidney tumor87
leukemia31
liver tumor41
lung tumor48
lymphoma13
non-neoplasia51
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer28
retinoblastoma43
skin tumor71
soft tissue/muscle tissue tumor55
uterine tumor66
Developmental Stage
TissuesTPM*
adult56
embryoid body57
blastocyst65
neonate64
fetus87
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.5
adrenal gland24.1
appendix26.8
bone marrow60.7
cerebral cortex23.2
colon37.5
duodenum23.8
esophagus20.1
gallbladder38.8
heart muscle13.4
kidney12.8
liver11.4
lung27.8
lymph node22.2
ovary36.1
pancreas13.3
placenta19.4
prostate15.6
salivary gland11.9
skin13.5
small intestine32.7
spleen21.2
stomach21.6
testis21
thyroid gland18.9
urinary bladder28.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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