Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q15041)
Protein (NX_Q15041)
Protein
Gene SymbolARL6IP1 to neXtProt (NX_Q15041)
DescriptionADP-ribosylation factor-like protein 6-interacting protein 1
Chromosome16
Location16p12.3 (18802991 ~ 18813000) to Ensembl
Sequene Features : Isoforms 3, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 36 3
2014-09-19protein level
1 24 3
2014-05-27protein level
1 24 3
2014-02-25protein level
1 23 3
2013-12-09protein level
1 18 3
2013-11-01protein level
1 17 2
2013-09-12protein level
1 17 2
2013-08-17protein level
1 17 2
2013-07-15protein level
1 12 0
2013-06-11protein level
1 12 0
2013-02-12protein level
1 5 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 6 0
2012-07-28protein level
1 6 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15041-1
0 5 0 23347.3672
NX_Q15041-2
0 4 0 20246.935
NX_Q15041-3
1 3 0 17147.0969
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714543,EBI-727209 SNX3  
  .negative regulation of early endosome to late endosome transport
.intralumenal vesicle formation
.negative regulation of protein transport
  + 13 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidylinositol-4-phosphate binding
.phosphatidylinositol-3-phosphate binding
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.early phagosome
  + 7 more...
2 EBI-714543,EBI-724909 SNX4  
  .positive regulation of histamine secretion by mast cell
.endocytic recycling
.vesicle organization
.protein transport
.leptin receptor binding
.transferrin receptor binding
.phosphatidylinositol binding
  + 2 more...
.protein complex
.early endosome membrane
.SNARE complex
  + 5 more...
3 EBI-714543,EBI-352908 SHMT2  
  .protein homotetramerization
.tetrahydrofolate interconversion
.glycine biosynthetic process from serine
  + 3 more...
.pyridoxal phosphate binding
.amino acid binding
.L-allo-threonine aldolase activity
  + 2 more...
.extracellular exosome
.mitochondrial nucleoid
.microtubule cytoskeleton
  + 4 more...
4 EBI-714543,EBI-359097 TUFM  
  .mitochondrial translational elongation
.mitochondrial translation
.organelle organization
.translational elongation
.poly(A) RNA binding
.GTP binding
.GTPase activity
.translation elongation factor activity
.extracellular exosome
.mitochondrial nucleoid
.membrane
.mitochondrion
5 EBI-714543,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
6 EBI-714543,EBI-1049924 TFAM  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.mitochondrial respiratory chain complex assembly
  + 8 more...
.mitochondrial light strand promoter sense binding
.poly(A) RNA binding
.DNA binding, bending
  + 4 more...
.mitochondrial nucleoid
.cytosol
.mitochondrial matrix
  + 2 more...
7 EBI-714543,EBI-9304251 GAD2  
  .response to drug
.neurotransmitter biosynthetic process
.neurotransmitter secretion
  + 2 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.perinuclear region of cytoplasm
.presynaptic membrane
  + 7 more...
8 EBI-714543,EBI-2822329 SNX1  
  .lamellipodium morphogenesis
.positive regulation of protein catabolic process
.retrograde transport, endosome to Golgi
  + 4 more...
.leptin receptor binding
.transferrin receptor binding
.identical protein binding
  + 3 more...
.protein complex
.intracellular membrane-bounded organelle
.early endosome membrane
  + 8 more...
9 EBI-714543,EBI-744685 RAB33A  
  .regulation of autophagic vacuole assembly
.Rab protein signal transduction
.antigen processing and presentation
  + 2 more...
.GTP binding
.GTPase activity
.plasma membrane
.Golgi apparatus
10 EBI-714543,EBI-10192441 FAM134C  
  .N/A .N/A .integral component of membrane
11 EBI-714543,EBI-2876502 ACSF2  
  .fatty acid metabolic process .ligase activity
.ATP binding
.mitochondrion
12 EBI-714543,EBI-7825321 MTERF3  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription regulatory region DNA binding
.double-stranded DNA binding
.mitochondrion
13 EBI-714543,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
14 EBI-714543,EBI-3921185 NAPB  
  .membrane fusion
.SNARE complex disassembly
.intracellular protein transport
.syntaxin binding
.soluble NSF attachment protein activity
.extracellular exosome
.SNARE complex
.vacuolar membrane
15 EBI-714543,EBI-2465479 GOLPH3  
  .asymmetric Golgi ribbon formation
.Golgi ribbon formation
.cell adhesion molecule production
  + 15 more...
.phosphatidylinositol-4-phosphate binding
.enzyme binding
.Golgi cisterna membrane
.Golgi cisterna
.plasma membrane
  + 7 more...
16 EBI-714543,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
17 EBI-714543,EBI-714881 SENP2  
  .regulation of G1/S transition of mitotic cell cycle
.spongiotrophoblast layer development
.labyrinthine layer development
  + 21 more...
.SUMO-specific protease activity .nuclear membrane
.cytoplasmic vesicle
.PML body
  + 2 more...
18 EBI-714543,EBI-715945 RTN4  
  .regulation of branching morphogenesis of a nerve
.endoplasmic reticulum tubular network organization
.cardiac epithelial to mesenchymal transition
  + 11 more...
.poly(A) RNA binding .extracellular exosome
.neuronal cell body
.cell projection
  + 5 more...
19 EBI-714543,EBI-517508 DIABLO  
  .intrinsic apoptotic signaling pathway
.neuron apoptotic process
.positive regulation of apoptotic process
  + 6 more...
.N/A .CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
20 EBI-714543,EBI-725924 SNX15  
  .intracellular protein transport .phosphatidylinositol binding .cytoplasmic vesicle membrane
.membrane
.cytosol
  + 2 more...
21 EBI-714543,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
22 EBI-714543,EBI-10323810 NDRG4  
  .positive regulation of ERK1 and ERK2 cascade
.cardiac muscle cell proliferation
.negative regulation of smooth muscle cell proliferation
  + 9 more...
.N/A .basolateral plasma membrane
.cytosol
.endoplasmic reticulum membrane
  + 2 more...
23 EBI-714543,EBI-1752602 SNX12  
  .negative regulation of early endosome to late endosome transport
.negative regulation of protein transport
.negative regulation of protein catabolic process
  + 6 more...
.phosphatidylinositol binding
.enzyme binding
.extracellular exosome
.extrinsic component of membrane
.early endosome
.endosome
24 EBI-714543,EBI-721147 PAM16  
  .cellular protein metabolic process
.negative regulation of ATPase activity
.protein import into mitochondrial matrix
.protein targeting to mitochondrion
.N/A .protein complex
.extrinsic component of mitochondrial inner membrane
.mitochondrial matrix
  + 2 more...
25 EBI-714543,EBI-719396 WIPI2  
  .nucleophagy
.protein localization to pre-autophagosomal structure
.cellular response to nitrogen starvation
  + 3 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidylinositol-3-phosphate binding
.protein complex
.pre-autophagosomal structure membrane
.extrinsic component of membrane
  + 4 more...
26 EBI-714543,EBI-739994 COL4A3BP  
  .mitochondrion morphogenesis
.lipid homeostasis
.small molecule metabolic process
  + 14 more...
.ceramide binding
.phosphatidylinositol-4-phosphate binding
.ceramide transporter activity
.protein kinase activity
.cytosol
.Golgi apparatus
.endoplasmic reticulum membrane
  + 2 more...
27 EBI-714543,EBI-10329449 SNX11  
  .vesicle organization
.endocytosis
.intracellular protein transport
.phosphatidylinositol phosphate binding .extrinsic component of membrane
.endosome
28 EBI-714543,EBI-10329478 SNX10  
  .protein localization to centrosome
.protein localization to cilium
.cilium assembly
  + 5 more...
.ATPase binding
.1-phosphatidylinositol binding
.extrinsic component of endosome membrane
.microtubule organizing center
.endoplasmic reticulum
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland516
ascites502
bladder703
blood294
bone167
bone marrow451
brain744
cervix247
connective tissue187
embryonic tissue347
esophagus595
eye191
heart189
intestine219
kidney512
larynx213
liver418
lung161
lymph45
lymph node66
mammary gland238
mouth211
muscle263
nerve386
ovary206
pancreas173
parathyroid339
pharynx613
pituitary gland181
placenta173
prostate226
salivary gland98
skin237
spleen355
stomach365
testis457
thymus313
thyroid193
trachea193
umbilical cord363
uterus232
vascular677
Health State
TissuesTPM*
normal392
adrenal tumor316
bladder carcinoma511
breast (mammary gland) tumor290
cervical tumor318
chondrosarcoma96
colorectal tumor79
esophageal tumor695
gastrointestinal tumor438
germ cell tumor562
glioma214
head and neck tumor171
kidney tumor885
leukemia243
liver tumor593
lung tumor145
lymphoma180
non-neoplasia341
ovarian tumor262
pancreatic tumor219
primitive neuroectodermal tumor of the CNS401
prostate cancer221
retinoblastoma430
skin tumor167
soft tissue/muscle tissue tumor127
uterine tumor199
Developmental Stage
TissuesTPM*
adult232
embryoid body257
blastocyst227
neonate1126
fetus393
infant595
juvenile935
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue106.2
adrenal gland157.1
appendix76.3
bone marrow121.7
cerebral cortex202.8
colon118
duodenum117.7
esophagus66
gallbladder129.5
heart muscle23.7
kidney107.1
liver160.9
lung65.9
lymph node115.8
ovary88.2
pancreas36.6
placenta81.2
prostate70.5
salivary gland58.4
skin52.5
small intestine105.7
spleen61.9
stomach116.3
testis116.3
thyroid gland102.3
urinary bladder126.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607669, gene) Adp-ribosylation-like factor 6-interacting protein 1; ARL6IP1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center