Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q15046)
Protein (NX_Q15046)
Protein
Gene SymbolKARS to neXtProt (NX_Q15046)
DescriptionLysine--tRNA ligase
Chromosome16
Location16q23.1 (75661622 ~ 75682541) to Ensembl
Sequene Features : Isoforms 2, Variants 93, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.viral process
.diadenosine tetraphosphate biosynthetic process
.gene expression
  + 3 more...
.metal ion binding
.amino acid binding
.ATP binding
  + 2 more...
.aminoacyl-tRNA synthetase multienzyme complex
.microtubule cytoskeleton
.plasma membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 93 11
2014-09-19protein level
2 76 11
2014-05-27protein level
2 76 11
2014-02-25protein level
2 76 11
2013-12-09protein level
2 49 11
2013-11-01protein level
2 47 7
2013-09-12protein level
2 47 7
2013-08-17protein level
2 47 7
2013-07-15protein level
2 34 4
2013-06-11protein level
2 34 4
2013-02-12protein level
2 19 11
2012-12-20protein level
2 18 11
2012-10-30protein level
2 24 11
2012-10-07protein level
2 24 6
2012-08-24protein level
2 19 6
2012-07-28protein level
2 19 6
2012-06-08protein level
2 21 6
2012-05-07protein level
2 20 6
2012-04-10protein level
2 20 6
2012-01-13protein level
2 18 6
2011-12-20protein level
2 18 6
2011-11-11protein level
2 18 6
2011-08-23protein level
2 18 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15046-1
1 26 0 68004.4007
NX_Q15046-2
3 26 0 71451.2352
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356367,EBI-354112 RPSA  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 13 more...
.poly(A) RNA binding
.ribosome binding
.laminin receptor activity
.structural constituent of ribosome
.extracellular exosome
.90S preribosome
.cytosolic small ribosomal subunit
  + 5 more...
2 EBI-356367,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites602
bladder66
blood147
bone195
bone marrow246
brain96
cervix288
connective tissue87
embryonic tissue169
esophagus49
eye277
heart145
intestine215
kidney104
larynx85
liver102
lung158
lymph406
lymph node211
mammary gland171
mouth105
muscle65
nerve64
ovary187
pancreas93
parathyroid48
pharynx49
pituitary gland121
placenta134
prostate126
salivary gland98
skin180
stomach167
testis211
thymus12
thyroid64
tonsil117
umbilical cord145
uterus124
vascular38
Health State
TissuesTPM*
normal107
adrenal tumor237
bladder carcinoma170
breast (mammary gland) tumor182
cervical tumor376
chondrosarcoma265
colorectal tumor222
esophageal tumor57
gastrointestinal tumor345
germ cell tumor140
glioma111
head and neck tumor89
kidney tumor159
leukemia275
liver tumor145
lung tumor184
lymphoma484
non-neoplasia82
ovarian tumor301
pancreatic tumor104
primitive neuroectodermal tumor of the CNS196
prostate cancer125
retinoblastoma495
skin tumor255
soft tissue/muscle tissue tumor167
uterine tumor122
Developmental Stage
TissuesTPM*
adult152
embryoid body157
blastocyst146
neonate64
fetus122
juvenile341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue54.3
adrenal gland47.1
appendix72
bone marrow62.5
cerebral cortex35.3
colon69.3
duodenum55.6
esophagus71.5
gallbladder55.6
heart muscle71.5
kidney52.1
liver33.9
lung46.9
lymph node87.6
ovary70.7
pancreas39.9
placenta59.1
prostate47.5
salivary gland58.8
skin57.7
small intestine58
spleen53.6
stomach48.7
testis91.7
thyroid gland67.9
urinary bladder81.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601421, gene) Lysyl-trna synthetase; KARSOMIM
2(#613641, phenotype) Charcot-marie-tooth disease, recessive intermediate b; CMTRIBOMIM
3(%613916, phenotype) Deafness, autosomal recessive 89; DFNB89OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center