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> Protein (NX_Q15075)
Protein (NX_Q15075)
Protein
Gene SymbolEEA1 to neXtProt (NX_Q15075)
DescriptionEarly endosome antigen 1
Chromosome12
Location12q22 (93164413 ~ 93323107) to Ensembl
Sequene Features : Isoforms 1, Variants 138, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.early endosome to late endosome transport
.synaptic vesicle to endosome fusion
.vesicle fusion
.endocytosis
.protein homodimerization activity
.GTP-dependent protein binding
.zinc ion binding
  + 2 more...
.extracellular exosome
.recycling endosome
.axonal spine
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 138 4
2014-09-19protein level
1 112 4
2014-05-27protein level
1 112 4
2014-02-25protein level
1 111 4
2013-12-09protein level
1 92 4
2013-11-01protein level
1 90 3
2013-09-12protein level
1 90 3
2013-08-17protein level
1 90 3
2013-07-15protein level
1 58 3
2013-06-11protein level
1 58 3
2013-02-12protein level
1 31 1
2012-12-20protein level
1 31 1
2012-10-30protein level
1 39 1
2012-10-07protein level
1 39 1
2012-08-24protein level
1 31 1
2012-07-28protein level
1 31 1
2012-06-08protein level
1 63 1
2012-05-07protein level
1 63 1
2012-04-10protein level
1 63 1
2012-01-13protein level
1 42 1
2011-12-20protein level
1 42 1
2011-11-11protein level
1 42 0
2011-08-23protein level
1 42 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15075-1
66 0 0 162366.7063
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-298113,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-298113,EBI-399437 RAB5A  
  .regulation of synaptic vesicle exocytosis
.receptor internalization involved in canonical Wnt signaling pathway
.regulation of filopodium assembly
  + 12 more...
.GDP binding
.GTP binding
.GTPase activity
.cytoplasmic side of early endosome membrane
.extracellular exosome
.recycling endosome
  + 22 more...
3 EBI-298113,EBI-399401 RAB5B  
  .plasma membrane to endosome transport
.Rab protein signal transduction
.regulation of endocytosis
  + 4 more...
.GTP-dependent protein binding
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.melanosome
.early endosome membrane
  + 6 more...
4 EBI-298113,EBI-2814750 SAMD9  
  .N/A .N/A .intracellular membrane-bounded organelle
.cytoplasm
5 EBI-298113,EBI-399456 RAB22A  
  .regulation of vesicle size
.Rab protein signal transduction
.metabolic process
  + 3 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.phagocytic vesicle
.phagocytic vesicle membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood16
bone41
brain23
cervix61
connective tissue13
embryonic tissue23
esophagus49
eye33
heart22
intestine38
kidney52
larynx42
liver73
lung23
lymph node77
mammary gland6
muscle94
nerve128
ovary29
pancreas4
parathyroid97
pharynx73
placenta77
prostate36
salivary gland49
skin47
spleen37
stomach10
testis2
trachea19
uterus47
vascular77
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor10
cervical tumor86
chondrosarcoma36
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
germ cell tumor18
glioma18
head and neck tumor22
kidney tumor43
leukemia10
liver tumor31
lymphoma13
non-neoplasia10
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer57
retinoblastoma64
skin tumor39
soft tissue/muscle tissue tumor47
uterine tumor22
Developmental Stage
TissuesTPM*
adult46
embryoid body14
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.5
adrenal gland7.4
appendix7.5
bone marrow2.8
cerebral cortex7.6
colon8.2
duodenum6
esophagus14.1
gallbladder8.6
heart muscle6.6
kidney6.8
liver6.8
lung7.2
lymph node5.4
ovary8.6
pancreas3.7
placenta8.9
prostate8.3
salivary gland5.2
skin8.5
small intestine6.5
spleen6.4
stomach6.7
testis5.8
thyroid gland8.1
urinary bladder9.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusLow
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeHigh
gallbladderMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
lungMedium
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Low
small intestineMedium
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605070, gene) Early endosome antigen 1; EEA1OMIM


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