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> Protein (NX_Q15109)
Protein (NX_Q15109)
Protein
Gene SymbolAGER to neXtProt (NX_Q15109)
DescriptionAdvanced glycosylation end product-specific receptor
Chromosome6
Location6p21.32 (32148745 ~ 32152101) to Ensembl
Sequene Features : Isoforms 10, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of NF-kappaB transcription factor activity
.induction of positive chemotaxis
.innate immune response
  + 4 more...
.S100 protein binding
.identical protein binding
.transmembrane signaling receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 44 6
2014-09-19protein level
10 31 6
2014-05-27protein level
9 29 6
2014-02-25protein level
9 22 6
2013-12-09protein level
9 16 6
2013-11-01protein level
9 16 5
2013-09-12protein level
9 16 5
2013-08-17protein level
4 16 5
2013-07-15protein level
4 16 5
2013-06-11protein level
4 16 5
2013-02-12protein level
4 16 18
2012-12-20protein level
4 15 18
2012-10-30protein level
4 17 18
2012-10-07protein level
4 17 5
2012-08-24protein level
4 17 5
2012-07-28protein level
4 16 5
2012-06-08protein level
4 20 5
2012-05-07protein level
4 20 5
2012-04-10protein level
3 20 5
2012-01-13protein level
3 9 5
2011-12-20protein level
3 9 5
2011-11-11protein level
3 9 5
2011-08-23protein level
2 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15109-1
0 13 0 42775.9741
NX_Q15109-10
0 11 0 41072.5034
NX_Q15109-2
1 9 0 36170.5889
NX_Q15109-3
0 12 0 37026.9225
NX_Q15109-4
0 12 0 38995.9077
NX_Q15109-5
1 4 0 13183.8934
NX_Q15109-6
0 13 0 44744.9593
NX_Q15109-7
0 13 0 41208.168
NX_Q15109-8
0 10 0 35300.3666
NX_Q15109-9
2 10 0 38355.0301
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1646426,EBI-711909 TTR  
  .thyroid hormone transport
.retinol metabolic process
.extracellular matrix organization
  + 3 more...
.thyroid hormone binding
.identical protein binding
.extracellular exosome
.protein complex
.cytoplasm
  + 2 more...
2 EBI-1646426,EBI-458391 S100B  
  .negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
3 EBI-1646426,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
4 EBI-1646426,EBI-743700 S100P  
  .endothelial cell migration
.response to organic substance
.calcium-dependent protein binding
.calcium ion binding
.magnesium ion binding
.extracellular exosome
.microvillus membrane
.cytoplasm
.nucleus
5 EBI-1646426,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
6 EBI-1646426,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
connective tissue26
ear62
embryonic tissue4
eye19
heart33
intestine4
lung146
lymph node33
mammary gland13
ovary9
pancreas9
prostate10
stomach10
testis4
thymus12
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor8
germ cell tumor7
leukemia31
lung tumor9
non-neoplasia10
prostate cancer19
Developmental Stage
TissuesTPM*
adult9
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.3
adrenal gland5.7
appendix10.9
bone marrow11.2
cerebral cortex3.1
colon2.8
duodenum4
esophagus3.2
gallbladder5.6
heart muscle3.1
kidney3.4
liver2
lung1043.4
lymph node15.8
ovary5.3
pancreas1.2
placenta6.3
prostate4.3
salivary gland3.6
skin7.7
small intestine5.5
spleen17.8
stomach5.5
testis4.6
thyroid gland11.2
urinary bladder4.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600214, gene) Advanced glycosylation end product-specific receptor; AGEROMIM


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