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> Protein (NX_Q15131)
Protein (NX_Q15131)
Protein
Gene SymbolCDK10 to neXtProt (NX_Q15131)
DescriptionCyclin-dependent kinase 10
Chromosome16
Location16q24.3 (89747145 ~ 89762772) to Ensembl
Sequene Features : Isoforms 7, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of MAPK cascade
.negative regulation of cell proliferation
.traversing start control point of mitotic cell cycle
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 44 2
2014-09-19protein level
7 35 2
2014-05-27protein level
4 35 2
2014-02-25protein level
4 35 2
2013-12-09protein level
4 23 2
2013-11-01protein level
4 22 1
2013-09-12protein level
4 22 1
2013-08-17protein level
4 22 1
2013-07-15protein level
4 15 1
2013-06-11protein level
4 15 1
2013-02-12protein level
4 9 4
2012-12-20protein level
4 8 4
2012-10-30protein level
4 12 4
2012-10-07protein level
4 12 1
2012-08-24protein level
4 12 1
2012-07-28protein level
4 12 1
2012-06-08protein level
4 12 1
2012-05-07protein level
4 11 1
2012-04-10protein level
4 11 1
2012-01-13protein level
4 6 1
2011-12-20protein level
4 6 1
2011-11-11protein level
4 6 1
2011-08-23protein level
4 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15131-1
1 17 0 41011.4905
NX_Q15131-2
0 14 0 32710.1696
NX_Q15131-3
1 12 0 31922.7379
NX_Q15131-4
1 12 0 30682.1643
NX_Q15131-5
1 8 0 21498.2203
NX_Q15131-6
2 5 0 17434.9094
NX_Q15131-7
1 12 0 32641.0064
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1646959,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
2 EBI-1646959,EBI-1646991 ETS2  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.cell differentiation
  + 4 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nucleoplasm
.nucleus
3 EBI-1646959,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites75
blood40
bone83
bone marrow41
brain45
cervix123
connective tissue13
embryonic tissue51
eye67
intestine73
kidney37
liver24
lung35
lymph node33
mammary gland39
mouth45
muscle28
nerve64
ovary19
pancreas18
placenta98
prostate42
skin23
spleen18
stomach41
testis39
thymus25
thyroid107
tonsil58
uterus43
Health State
TissuesTPM*
normal50
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma96
colorectal tumor71
gastrointestinal tumor42
germ cell tumor11
glioma18
head and neck tumor44
kidney tumor29
leukemia63
liver tumor20
lung tumor29
lymphoma69
non-neoplasia51
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer38
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult61
embryoid body28
blastocyst65
fetus52
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.1
adrenal gland38.4
appendix42.3
bone marrow26.2
cerebral cortex23.9
colon34.6
duodenum57.7
esophagus24
gallbladder39.1
heart muscle18.7
kidney47.7
liver29.5
lung41.8
lymph node43
ovary31.8
pancreas32.5
placenta36.5
prostate38.3
salivary gland36.1
skin60.8
small intestine59.4
spleen51.7
stomach59.2
testis28.6
thyroid gland59.5
urinary bladder29.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*603464, gene) Cyclin-dependent kinase 10; CDK10OMIM


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