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> Protein (NX_Q15154)
Protein (NX_Q15154)
Protein
Gene SymbolPCM1 to neXtProt (NX_Q15154)
DescriptionPericentriolar material 1 protein
Chromosome8
Location8p22 (17780349 ~ 17885478) to Ensembl
Sequene Features : Isoforms 3, Variants 216, PTMs 81 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neuronal stem cell maintenance
.positive regulation of intracellular protein transport
.protein localization to centrosome
  + 12 more...
.identical protein binding .protein complex
.ciliary basal body
.centriolar satellite
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 216 81
2014-09-19protein level
3 183 81
2014-05-27protein level
3 183 82
2014-02-25protein level
3 183 81
2013-12-09protein level
3 97 81
2013-11-01protein level
3 96 71
2013-09-12protein level
3 96 72
2013-08-17protein level
3 96 72
2013-07-15protein level
3 68 47
2013-06-11protein level
3 68 47
2013-02-12protein level
3 37 114
2012-12-20protein level
3 31 114
2012-10-30protein level
3 60 114
2012-10-07protein level
3 60 49
2012-08-24protein level
3 58 49
2012-07-28protein level
3 58 49
2012-06-08protein level
3 33 49
2012-05-07protein level
3 33 49
2012-04-10protein level
3 33 49
2012-01-13protein level
3 33 49
2011-12-20protein level
3 38 49
2011-11-11protein level
3 38 43
2011-08-23protein level
3 38 40
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15154-1
3 80 0 228391.67
NX_Q15154-2
1 80 0 222084.6865
NX_Q15154-3
2 22 0 59162.322
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741421,EBI-1805484 BBS1  
  .protein localization to cilium
.response to stimulus
.photoreceptor cell maintenance
  + 6 more...
.smoothened binding
.patched binding
.RNA polymerase II repressing transcription factor binding
.ciliary membrane
.ciliary basal body
.BBSome
  + 3 more...
2 EBI-741421,EBI-1805814 BBS4  
  .protein localization to centrosome
.protein localization to cilium
.regulation of cilium beat frequency involved in ciliary motility
  + 37 more...
.beta-tubulin binding
.alpha-tubulin binding
.dynactin binding
  + 2 more...
.ciliary membrane
.ciliary basal body
.ciliary transition zone
  + 9 more...
3 EBI-741421,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
4 EBI-741421,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder33
blood98
bone83
bone marrow143
brain66
cervix144
connective tissue73
ear62
embryonic tissue93
esophagus49
eye52
heart167
intestine51
kidney94
larynx42
liver97
lung95
lymph45
lymph node155
mammary gland132
mouth120
muscle122
nerve64
ovary29
pancreas51
parathyroid48
pharynx122
pituitary gland60
placenta60
prostate63
salivary gland49
skin28
spleen56
stomach167
testis179
thymus87
thyroid107
trachea193
uterus146
vascular116
Health State
TissuesTPM*
normal91
adrenal tumor79
breast (mammary gland) tumor107
cervical tumor202
chondrosarcoma36
colorectal tumor44
esophageal tumor57
gastrointestinal tumor135
germ cell tumor110
glioma27
head and neck tumor112
kidney tumor72
leukemia148
liver tumor145
lung tumor77
lymphoma55
non-neoplasia72
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS31
prostate cancer48
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor119
uterine tumor177
Developmental Stage
TissuesTPM*
adult97
embryoid body57
blastocyst162
fetus132
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.8
adrenal gland43.9
appendix38
bone marrow47.7
cerebral cortex40.2
colon34.7
duodenum27.8
esophagus33.5
gallbladder39.8
heart muscle34.7
kidney33.2
liver26.4
lung41
lymph node49.2
ovary56.9
pancreas20.6
placenta35.1
prostate42.2
salivary gland34.4
skin36.9
small intestine27.8
spleen41.5
stomach32.2
testis151.7
thyroid gland55
urinary bladder38.3
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastLow
bronchusHigh
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleLow
liverLow
lungLow
lymph nodeMedium
nasopharynxHigh
ovaryHigh
pancreasMedium
placentaMedium
prostateMedium
rectumMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#188550, phenotype) Thyroid carcinoma, papillaryOMIM
2(*600299, gene) Pericentriolar material 1; PCM1OMIM
3papillary thyroid;chronic myeloid leukemia;Myeloproliferative disorderCGP


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