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> Protein (NX_Q15208)
Protein (NX_Q15208)
Protein
Gene SymbolSTK38 to neXtProt (NX_Q15208)
DescriptionSerine/threonine-protein kinase 38
Chromosome6
Location6p21.31 (36461669 ~ 36515247) to Ensembl
Sequene Features : Isoforms 1, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of MAP kinase activity
.intracellular signal transduction
.protein phosphorylation
.cellular protein modification process
.mitogen-activated protein kinase kinase kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.MLL5-L complex
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 62 5
2014-09-19protein level
1 49 5
2014-05-27protein level
1 49 6
2014-02-25protein level
1 47 6
2013-12-09protein level
1 45 6
2013-11-01protein level
1 43 6
2013-09-12protein level
1 43 6
2013-08-17protein level
1 43 6
2013-07-15protein level
1 27 6
2013-06-11protein level
1 27 6
2013-02-12protein level
1 11 7
2012-12-20protein level
1 10 7
2012-10-30protein level
1 11 7
2012-10-07protein level
1 11 7
2012-08-24protein level
1 5 7
2012-07-28protein level
1 5 7
2012-06-08protein level
1 9 7
2012-05-07protein level
1 9 7
2012-04-10protein level
1 9 7
2012-01-13protein level
1 9 7
2011-12-20protein level
1 9 7
2011-11-11protein level
1 9 5
2011-08-23protein level
1 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15208-1
20 0 2 54155.2202
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-458376,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
2 EBI-458376,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
3 EBI-458376,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
4 EBI-458376,EBI-748229 MOB1A  
  .hippo signaling .metal ion binding .extracellular exosome
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
bladder167
blood220
bone167
bone marrow20
brain28
cervix103
connective tissue20
ear62
embryonic tissue70
esophagus49
eye33
heart67
intestine60
kidney75
larynx42
liver29
lung62
lymph node89
mammary gland125
mouth619
muscle28
ovary19
pancreas32
pharynx49
pituitary gland60
placenta31
prostate21
skin42
spleen93
stomach188
testis75
thymus125
thyroid42
trachea212
uterus146
vascular96
Health State
TissuesTPM*
normal55
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor118
cervical tumor144
chondrosarcoma84
colorectal tumor62
esophageal tumor57
gastrointestinal tumor143
germ cell tumor75
head and neck tumor313
kidney tumor14
leukemia232
liver tumor31
lung tumor19
lymphoma13
non-neoplasia20
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor79
uterine tumor77
Developmental Stage
TissuesTPM*
adult61
embryoid body71
blastocyst48
neonate64
fetus62
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.1
adrenal gland8.4
appendix28.4
bone marrow16.5
cerebral cortex4.1
colon33.1
duodenum20.4
esophagus24.4
gallbladder22
heart muscle13.8
kidney14.2
liver9.1
lung17.7
lymph node32.1
ovary8
pancreas3.8
placenta17.8
prostate13.5
salivary gland11.7
skin24.4
small intestine25.2
spleen20.7
stomach21.3
testis11.3
thyroid gland7
urinary bladder33
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606964, gene) Serine/threonine protein kinase 38; STK38OMIM


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