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> Protein (NX_Q15262)
Protein (NX_Q15262)
Protein
Gene SymbolPTPRK to neXtProt (NX_Q15262)
DescriptionReceptor-type tyrosine-protein phosphatase kappa
Chromosome6
Location6q22.33 (128289924 ~ 128841870) to Ensembl
Sequene Features : Isoforms 4, Variants 242, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.focal adhesion assembly
.negative regulation of transcription, DNA-templated
.negative regulation of cell cycle
  + 12 more...
.gamma-catenin binding
.protein kinase binding
.beta-catenin binding
  + 2 more...
.neuronal cell body
.leading edge membrane
.dendrite
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 242 16
2014-09-19protein level
4 174 16
2014-05-27protein level
4 172 16
2014-02-25protein level
3 169 16
2013-12-09protein level
3 142 16
2013-11-01protein level
3 121 16
2013-09-12protein level
3 121 16
2013-08-17protein level
3 121 16
2013-07-15protein level
3 71 16
2013-06-11protein level
3 71 16
2013-02-12protein level
3 26 45
2012-12-20protein level
3 29 45
2012-10-30protein level
3 32 45
2012-10-07protein level
3 32 15
2012-08-24protein level
3 17 15
2012-07-28protein level
3 17 15
2012-06-08protein level
3 24 15
2012-05-07protein level
3 24 15
2012-04-10protein level
3 24 15
2012-01-13protein level
3 19 15
2011-12-20protein level
3 19 15
2011-11-11protein level
3 19 15
2011-08-23protein level
2 19 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15262-1
1 60 1 161997.9395
NX_Q15262-2
0 61 1 162068.9764
NX_Q15262-3
0 62 1 162915.4129
NX_Q15262-4
1 61 1 164507.3267
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-474052,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-474052,EBI-3893481 LOX  
  .response to steroid hormone
.elastic fiber assembly
.response to drug
  + 6 more...
.copper ion binding
.protein-lysine 6-oxidase activity
.nucleus
.extracellular space
.collagen trimer
  + 2 more...
3 EBI-474052,EBI-2257090 TEK  
  .negative regulation of endothelial cell apoptotic process
.regulation of endothelial cell apoptotic process
.positive regulation of actin cytoskeleton reorganization
  + 45 more...
.ATP binding
.receptor activity
.transmembrane receptor protein tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.membrane raft
.apical plasma membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder133
bone69
brain44
connective tissue26
embryonic tissue75
esophagus49
eye23
heart55
intestine99
kidney75
larynx85
liver53
lung56
mammary gland59
mouth90
muscle28
ovary39
pancreas51
pharynx270
pituitary gland60
placenta38
prostate21
skin23
stomach41
testis11
thymus12
thyroid21
tonsil58
uterus38
vascular58
Health State
TissuesTPM*
normal48
bladder carcinoma170
breast (mammary gland) tumor32
chondrosarcoma36
colorectal tumor124
esophageal tumor57
gastrointestinal tumor33
germ cell tumor41
glioma83
head and neck tumor141
kidney tumor43
liver tumor20
lung tumor38
non-neoplasia20
ovarian tumor39
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor66
Developmental Stage
TissuesTPM*
adult55
embryoid body71
blastocyst81
fetus73
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.1
adrenal gland7.1
appendix14.8
cerebral cortex29.2
colon41.2
duodenum40.8
esophagus23.8
gallbladder59.6
heart muscle21.8
kidney18.7
liver23.2
lung24
lymph node11.1
ovary24.2
pancreas20.1
placenta28
prostate20.3
salivary gland16.6
skin11.3
small intestine37.4
spleen11.6
stomach38.5
testis5.5
thyroid gland23.4
urinary bladder39.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602545, gene) Protein-tyrosine phosphatase, receptor-type, kappa; PTPRKOMIM


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