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> Protein (NX_Q15323)
Protein (NX_Q15323)
Protein
Gene SymbolKRT31 to neXtProt (NX_Q15323)
DescriptionKeratin, type I cuticular Ha1
Chromosome17
Location17q21.2 (39549976 ~ 39553844) to Ensembl
Sequene Features : Isoforms 1, Variants 96, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 96 0
2014-09-19protein level
1 76 0
2014-05-27protein level
1 76 0
2014-02-25protein level
1 76 0
2013-12-09protein level
1 65 0
2013-11-01protein level
1 62 0
2013-09-12protein level
1 62 0
2013-08-17protein level
1 62 0
2013-07-15protein level
1 41 0
2013-06-11protein level
1 41 0
2013-02-12protein level
1 20 0
2012-12-20protein level
1 20 0
2012-10-30protein level
1 22 0
2012-10-07protein level
1 22 0
2012-08-24protein level
1 15 0
2012-07-28protein level
1 15 0
2012-06-08protein level
1 16 0
2012-05-07protein level
1 15 0
2012-04-10protein level
1 15 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15323-1
7 0 16 47206.917
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-948001,EBI-10173955 C5orf60  
  .N/A .N/A .integral component of membrane
2 EBI-948001,EBI-10174045 PRR19  
  .N/A .N/A .N/A
3 EBI-948001,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
4 EBI-948001,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
5 EBI-948001,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
6 EBI-948001,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
7 EBI-948001,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
8 EBI-948001,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
9 EBI-948001,EBI-743231 ASMTL  
  .N/A .O-methyltransferase activity .cytoplasm
10 EBI-948001,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
11 EBI-948001,EBI-712648 AGR2  
  .mucus secretion
.lung goblet cell differentiation
.dystroglycan binding .endoplasmic reticulum
.mitochondrion
.extracellular region
12 EBI-948001,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
13 EBI-948001,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
14 EBI-948001,EBI-353997 GNAI2  
  .regulation of calcium ion transport
.cell division
.negative regulation of synaptic transmission
  + 17 more...
.metal ion binding
.G-protein beta/gamma-subunit complex binding
.GTP binding
  + 3 more...
.extracellular exosome
.membrane raft
.vesicle
  + 8 more...
15 EBI-948001,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
16 EBI-948001,EBI-475899 INSR  
  .cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
17 EBI-948001,EBI-3870390 CRH  
  .positive regulation of behavioral fear response
.positive regulation of corticosterone secretion
.regulation of N-methyl-D-aspartate selective glutamate receptor activity
  + 49 more...
.neuropeptide hormone activity
.hormone activity
.receptor binding
.perikaryon
.varicosity
.cytoplasm
  + 2 more...
18 EBI-948001,EBI-9008836 CHRNG  
  .transmembrane transport
.regulation of membrane potential
.synaptic transmission
  + 3 more...
.acetylcholine receptor activity
.channel activity
.acetylcholine-activated cation-selective channel activity
.postsynaptic membrane
.cell junction
.acetylcholine-gated channel complex
  + 2 more...
19 EBI-948001,EBI-5462635 CTSG  
  .neutrophil mediated killing of gram-positive bacterium
.defense response to fungus
.positive regulation of immune response
  + 10 more...
.peptidase activity
.heparin binding
.serine-type endopeptidase activity
.extracellular exosome
.secretory granule
.cell surface
  + 4 more...
20 EBI-948001,EBI-353467 GSTP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.glutathione derivative biosynthetic process
.negative regulation of monocyte chemotactic protein-1 production
  + 27 more...
.nitric oxide binding
.dinitrosyl-iron complex binding
.S-nitrosoglutathione binding
  + 3 more...
.TRAF2-GSTP1 complex
.extracellular exosome
.vesicle
  + 7 more...
21 EBI-948001,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
22 EBI-948001,EBI-352528 HSPD1  
  .protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
23 EBI-948001,EBI-356254 SLC25A6  
  .regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
24 EBI-948001,EBI-702187 KRT5  
  .cell junction assembly
.hemidesmosome assembly
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.keratin filament
.membrane
  + 6 more...
25 EBI-948001,EBI-724466 PRF1  
  .defense response to virus
.protein homooligomerization
.cytolysis
  + 5 more...
.wide pore channel activity
.calcium ion binding
.cytolytic granule
.endosome lumen
.cytoplasmic membrane-bounded vesicle
  + 4 more...
26 EBI-948001,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
27 EBI-948001,EBI-3906571 CD33  
  .negative regulation of cell proliferation
.cell-cell signaling
.signal transduction
.cell adhesion
.carbohydrate binding
.receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
28 EBI-948001,EBI-715032 COX5A  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 3 more...
.metal ion binding
.electron carrier activity
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
29 EBI-948001,EBI-10200977 COMT  
  .regulation of sensory perception of pain
.positive regulation of homocysteine metabolic process
.negative regulation of smooth muscle cell proliferation
  + 20 more...
.catechol O-methyltransferase activity
.O-methyltransferase activity
.magnesium ion binding
.extracellular exosome
.postsynaptic membrane
.cell body
  + 7 more...
30 EBI-948001,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
31 EBI-948001,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
32 EBI-948001,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
33 EBI-948001,EBI-6590057 BTC  
  .positive regulation of fibroblast proliferation
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
  + 9 more...
.growth factor activity
.epidermal growth factor receptor binding
.integral component of membrane
.plasma membrane
.extracellular space
.extracellular region
34 EBI-948001,EBI-1247312 KRT2  
  .keratinocyte migration
.keratinocyte proliferation
.keratinocyte activation
  + 2 more...
.structural constituent of cytoskeleton .extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 6 more...
35 EBI-948001,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
36 EBI-948001,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
37 EBI-948001,EBI-2558314 ALDH3B1  
  .oxidation-reduction process
.aldehyde catabolic process
.cellular response to oxidative stress
  + 3 more...
.aldehyde dehydrogenase [NAD(P)+] activity
.3-chloroallyl aldehyde dehydrogenase activity
.extracellular exosome
.vesicle
.plasma membrane
  + 2 more...
38 EBI-948001,EBI-10210114 NPBWR2  
  .opioid receptor signaling pathway
.synaptic transmission
.neuropeptide signaling pathway
  + 2 more...
.neuropeptide binding
.neuropeptide receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
39 EBI-948001,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
40 EBI-948001,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
41 EBI-948001,EBI-750494 SMCP  
  .sperm motility
.penetration of zona pellucida
.N/A .mitochondrial membrane
.mitochondrion
.cytoplasm
42 EBI-948001,EBI-10211741 GNG10  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.signal transducer activity
.GTPase activity
.extracellular exosome
.plasma membrane
.heterotrimeric G-protein complex
43 EBI-948001,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
44 EBI-948001,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
45 EBI-948001,EBI-746103 AQP5  
  .transmembrane transport
.camera-type eye morphogenesis
.saliva secretion
  + 8 more...
.glycerol channel activity
.water channel activity
.extracellular exosome
.apical plasma membrane
.basal plasma membrane
  + 4 more...
46 EBI-948001,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
47 EBI-948001,EBI-10215880 MAP3K7CL  
  .N/A .N/A .cytosol
.nucleus
48 EBI-948001,EBI-751440 CLDN2  
  .calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules .identical protein binding
.structural molecule activity
.extracellular exosome
.integral component of membrane
.tight junction
.plasma membrane
49 EBI-948001,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
50 EBI-948001,EBI-10220734 GNG5  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.PDZ domain binding
.signal transducer activity
.GTPase activity
.extracellular exosome
.membrane
.plasma membrane
.heterotrimeric G-protein complex
51 EBI-948001,EBI-6693977 FKBP1B  
  .cell communication by electrical coupling involved in cardiac conduction
.calcium ion transmembrane transport
.negative regulation of insulin secretion involved in cellular response to glucose stimulus
  + 27 more...
.ion channel binding
.cyclic nucleotide binding
.calcium channel inhibitor activity
  + 3 more...
.calcium channel complex
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
52 EBI-948001,EBI-10221390 KRT83  
  .hair cycle
.epidermis development
.aging
.structural molecule activity .keratin filament
.extracellular space
53 EBI-948001,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
54 EBI-948001,EBI-721019 KLC1  
  .stress granule disassembly
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.viral process
  + 4 more...
.microtubule motor activity
.motor activity
.growth cone
.cytoplasmic membrane-bounded vesicle
.membrane
  + 3 more...
55 EBI-948001,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
56 EBI-948001,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
57 EBI-948001,EBI-713355 GPS2  
  .negative regulation of JNK cascade
.negative regulation of GTPase activity
.JNK cascade
  + 4 more...
.GTPase inhibitor activity
.transcription corepressor activity
.transcriptional repressor complex
.nucleoplasm
58 EBI-948001,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
59 EBI-948001,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
60 EBI-948001,EBI-739648 KRT81  
  .N/A .structural molecule activity .keratin filament
.extracellular space
61 EBI-948001,EBI-10233928 ICAM4  
  .regulation of immune response
.extracellular matrix organization
.single organismal cell-cell adhesion
.cell adhesion
.integrin binding .integral component of membrane
.integral component of plasma membrane
.plasma membrane
  + 2 more...
62 EBI-948001,EBI-2510602 JOSD1  
  .N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
63 EBI-948001,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
64 EBI-948001,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
65 EBI-948001,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
66 EBI-948001,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
67 EBI-948001,EBI-2952676 KRT71  
  .intermediate filament organization
.hair follicle morphogenesis
.structural molecule activity .extracellular exosome
.keratin filament
.cytoplasm
68 EBI-948001,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
69 EBI-948001,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
70 EBI-948001,EBI-4395687 ZNF569  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
71 EBI-948001,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
72 EBI-948001,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
73 EBI-948001,EBI-6447954 TTC23  
  .N/A .N/A .N/A
74 EBI-948001,EBI-2514135 KRT79  
  .N/A .enzyme binding
.structural molecule activity
.extracellular exosome
.keratin filament
75 EBI-948001,EBI-744560 WDR25  
  .N/A .N/A .N/A
76 EBI-948001,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
77 EBI-948001,EBI-5458784 RPUSD3  
  .pseudouridine synthesis .poly(A) RNA binding
.pseudouridine synthase activity
.N/A
78 EBI-948001,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
79 EBI-948001,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
80 EBI-948001,EBI-10258233 CATIP  
  .cilium organization
.actin filament polymerization
.calmodulin binding .actin cytoskeleton
.plasma membrane
.cytoplasm
.nucleus
81 EBI-948001,EBI-3916986 SPATA24  
  .cell differentiation
.spermatogenesis
.multicellular organismal development
  + 2 more...
.DNA binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
82 EBI-948001,EBI-5458774 COA5  
  .N/A .N/A .mitochondrion
83 EBI-948001,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
84 EBI-948001,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
85 EBI-948001,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
86 EBI-948001,EBI-8650724 CARKD  
  .nicotinamide nucleotide metabolic process .ADP-dependent NAD(P)H-hydrate dehydratase activity
.ATP-dependent NAD(P)H-hydrate dehydratase activity
.ATP binding
.mitochondrion
87 EBI-948001,EBI-742102 EXOC8  
  .membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
88 EBI-948001,EBI-749051 C6orf165  
  .N/A .N/A .N/A
89 EBI-948001,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
90 EBI-948001,EBI-10265323 RIBC1  
  .N/A .N/A .N/A
91 EBI-948001,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
92 EBI-948001,EBI-745040 CCDC112  
  .N/A .N/A .N/A
93 EBI-948001,EBI-752049 FAM71C  
  .N/A .N/A .N/A
94 EBI-948001,EBI-10270828 NAV1  
  .neuron migration
.microtubule bundle formation
.N/A .microtubule
.cytoplasm
95 EBI-948001,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
96 EBI-948001,EBI-747505 C1orf216  
  .N/A .N/A .N/A
97 EBI-948001,EBI-746041 CCER1  
  .N/A .N/A .N/A
98 EBI-948001,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
99 EBI-948001,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
100 EBI-948001,EBI-7199479 PTPMT1  
  .inositol phosphate dephosphorylation
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 4 more...
.phosphatidylglycerophosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.integral component of mitochondrial inner membrane
.mitochondrion
.nucleus
101 EBI-948001,EBI-1392258 PSPC1  
  .rhythmic process
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
.transcription, DNA-templated
.poly(A) RNA binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 3 more...
102 EBI-948001,EBI-79084 SHC3  
  .neurotrophin TRK receptor signaling pathway
.synaptic transmission, glutamatergic
.insulin receptor signaling pathway
  + 5 more...
.receptor tyrosine kinase binding
.protein kinase binding
.signal transducer activity
.plasma membrane
.cytosol
103 EBI-948001,EBI-1380477 INPP5D  
  .leukocyte migration
.T cell receptor signaling pathway
.negative regulation of immune response
  + 22 more...
.phosphatidylinositol trisphosphate phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.membrane
.cytosol
104 EBI-948001,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
105 EBI-948001,EBI-741068 FBXW5  
  .centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
106 EBI-948001,EBI-723276 PSMG2  
  .proteasome assembly
.negative regulation of apoptotic process
.mitotic spindle assembly checkpoint
.N/A .nucleus
107 EBI-948001,EBI-726510 LENG1  
  .N/A .N/A .N/A
108 EBI-948001,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
109 EBI-948001,EBI-10286106 LINC00526  
  .N/A .N/A .N/A
110 EBI-948001,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
111 EBI-948001,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
112 EBI-948001,EBI-10185348 CCDC120  
  .N/A .N/A .N/A
113 EBI-948001,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
114 EBI-948001,EBI-744267 RADIL  
  .substrate adhesion-dependent cell spreading
.multicellular organismal development
.signal transduction
.N/A .microtubule
115 EBI-948001,EBI-719840 CCDC17  
  .N/A .N/A .N/A
116 EBI-948001,EBI-10291310 HSPA12B  
  .N/A .ATP binding .N/A
117 EBI-948001,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
118 EBI-948001,EBI-3916225 FOXB1  
  .cell migration in diencephalon
.inferior colliculus development
.mammary gland lobule development
  + 19 more...
.sequence-specific DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
119 EBI-948001,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
120 EBI-948001,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
121 EBI-948001,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
122 EBI-948001,EBI-749162 INPP5K  
  .positive regulation of renal water transport
.negative regulation of glycogen (starch) synthase activity
.ruffle assembly
  + 35 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.inositol trisphosphate phosphatase activity
  + 7 more...
.perinuclear region of cytoplasm
.neuron projection
.ruffle membrane
  + 8 more...
123 EBI-948001,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
124 EBI-948001,EBI-744023 FAM103A1  
  .recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
.methylation
.7-methylguanosine mRNA capping
.poly(A) RNA binding
.RNA binding
.mRNA cap binding complex
.nucleus
125 EBI-948001,EBI-10298556 LMF2  
  .N/A .N/A .integral component of membrane
.membrane
.endoplasmic reticulum membrane
126 EBI-948001,EBI-10298801 SPON2  
  .cellular response to lipopolysaccharide
.positive regulation of macrophage cytokine production
.defense response to virus
  + 9 more...
.metal ion binding
.antigen binding
.lipopolysaccharide binding
.extracellular exosome
.extracellular space
.proteinaceous extracellular matrix
127 EBI-948001,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
128 EBI-948001,EBI-9675976 SNRNP25  
  .RNA splicing
.mRNA processing
.N/A .intercellular bridge
.cytoplasm
.U12-type spliceosomal complex
  + 2 more...
129 EBI-948001,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
130 EBI-948001,EBI-2821497 TMEM106C  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum membrane
131 EBI-948001,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
132 EBI-948001,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
133 EBI-948001,EBI-742953 DGCR6L  
  .N/A .N/A .nucleus
134 EBI-948001,EBI-1993677 ASPSCR1  
  .membrane organization
.regulation of glucose import
.glucose homeostasis
.intracellular protein transport
.N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
135 EBI-948001,EBI-10303490 SEMA4C  
  .semaphorin-plexin signaling pathway
.muscle cell differentiation
.positive regulation of stress-activated MAPK cascade
  + 3 more...
.receptor activity .postsynaptic membrane
.synaptic vesicle membrane
.cell junction
  + 3 more...
136 EBI-948001,EBI-2872322 SMG9  
  .gene expression
.nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.identical protein binding .cytosol
.intracellular
137 EBI-948001,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
138 EBI-948001,EBI-741626 FAM124B  
  .N/A .N/A .N/A
139 EBI-948001,EBI-10307654 TMEM231  
  .cilium assembly
.smoothened signaling pathway
.N/A .ciliary membrane
.TCTN-B9D complex
.ciliary transition zone
.integral component of membrane
140 EBI-948001,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
141 EBI-948001,EBI-2836158 C12orf49  
  .N/A .N/A .extracellular region
142 EBI-948001,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
143 EBI-948001,EBI-1053902 MRPL40  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding .mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
144 EBI-948001,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
145 EBI-948001,EBI-949319 KLC4  
  .N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
146 EBI-948001,EBI-2859285 C19orf73  
  .N/A .N/A .N/A
147 EBI-948001,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
148 EBI-948001,EBI-8799578 GFOD1  
  .N/A .oxidoreductase activity .extracellular region
149 EBI-948001,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
150 EBI-948001,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
151 EBI-948001,EBI-357355 UXT  
  .centrosome organization
.mitochondrion transport along microtubule
.microtubule cytoskeleton organization
.negative regulation of transcription from RNA polymerase II promoter
.beta-tubulin binding
.microtubule binding
.chromatin binding
.RNA polymerase II transcription corepressor activity
.cytoskeleton
.centrosome
.cytoplasm
.nucleus
152 EBI-948001,EBI-10320266 ZNF69  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
153 EBI-948001,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
154 EBI-948001,EBI-748350 RTDR1  
  .N/A .N/A .N/A
155 EBI-948001,EBI-310660 ATXN7L1  
  .N/A .N/A .N/A
156 EBI-948001,EBI-2688184 ZNF148  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.substantia nigra development
  + 6 more...
.metal ion binding
.sequence-specific DNA binding
.double-stranded DNA binding
  + 2 more...
.Golgi apparatus
.nucleoplasm
157 EBI-948001,EBI-4291090 GNE  
  .carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
158 EBI-948001,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
159 EBI-948001,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
160 EBI-948001,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain12
esophagus148
eye4
intestine8
larynx42
lung8
mouth15
muscle9
uterus4
Health State
TissuesTPM*
normal5
colorectal tumor17
esophageal tumor173
head and neck tumor14
lung tumor19
uterine tumor11
Developmental Stage
TissuesTPM*
adult7
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex1.1
esophagus17.6
skin35
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601077, gene) Keratin 31; KRT31OMIM


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