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> Protein (NX_Q15424)
Protein (NX_Q15424)
Protein
Gene SymbolSAFB to neXtProt (NX_Q15424)
DescriptionScaffold attachment factor B1
Chromosome19
Location19p13.3 (5623046 ~ 5668489) to Ensembl
Sequene Features : Isoforms 4, Variants 93, PTMs 32 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.hormone metabolic process
.growth
  + 3 more...
.poly(A) RNA binding
.double-stranded DNA binding
.chromatin binding
  + 2 more...
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 93 32
2014-09-19protein level
4 69 33
2014-05-27protein level
4 69 49
2014-02-25protein level
4 69 43
2013-12-09protein level
4 51 43
2013-11-01protein level
4 47 39
2013-09-12protein level
4 47 39
2013-08-17protein level
4 47 39
2013-07-15protein level
2 27 39
2013-06-11protein level
2 27 39
2013-02-12protein level
1 9 40
2012-12-20protein level
1 8 40
2012-10-30protein level
1 14 40
2012-10-07protein level
1 14 40
2012-08-24protein level
1 14 40
2012-07-28protein level
1 14 40
2012-06-08protein level
1 20 38
2012-05-07protein level
1 14 38
2012-04-10protein level
1 14 38
2012-01-13protein level
1 15 38
2011-12-20protein level
1 15 38
2011-11-11protein level
1 15 25
2011-08-23protein level
1 15 25
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15424-1
0 21 9 102579.2228
NX_Q15424-2
1 18 9 95122.945
NX_Q15424-3
0 21 9 102792.3446
NX_Q15424-4
0 21 9 102705.3128
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348298,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-348298,EBI-352869 SAFB2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
3 EBI-348298,EBI-5773439 SRPK1  
  .regulation of mRNA processing
.regulation of mRNA splicing, via spliceosome
.innate immune response
  + 9 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.nuclear matrix
.plasma membrane
.endoplasmic reticulum
  + 3 more...
4 EBI-348298,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites200
bladder66
blood49
bone41
bone marrow82
brain179
cervix164
connective tissue73
embryonic tissue206
esophagus396
eye114
heart67
intestine163
kidney104
larynx42
liver73
lung155
lymph519
lymph node189
mammary gland132
mouth302
muscle28
nerve64
ovary226
pancreas93
parathyroid437
placenta215
prostate79
salivary gland148
skin80
spleen206
stomach83
testis151
thymus715
thyroid64
trachea38
uterus116
vascular77
Health State
TissuesTPM*
normal136
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor150
cervical tumor202
chondrosarcoma60
colorectal tumor115
esophageal tumor463
gastrointestinal tumor135
germ cell tumor239
glioma242
head and neck tumor186
kidney tumor101
leukemia254
liver tumor104
lung tumor107
lymphoma346
non-neoplasia175
ovarian tumor236
pancreatic tumor76
primitive neuroectodermal tumor of the CNS149
prostate cancer134
retinoblastoma107
skin tumor63
soft tissue/muscle tissue tumor71
uterine tumor99
Developmental Stage
TissuesTPM*
adult136
embryoid body171
blastocyst260
neonate128
fetus219
infant42
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.5
adrenal gland39.9
appendix53.2
bone marrow52.1
cerebral cortex40.2
colon33.6
duodenum42.8
esophagus27.3
gallbladder37
heart muscle27.9
kidney37.2
liver22.3
lung35.6
lymph node60.1
ovary48.1
pancreas19.9
placenta41.8
prostate43.5
salivary gland32.1
skin49.3
small intestine40.9
spleen62.6
stomach41.3
testis45.5
thyroid gland33.8
urinary bladder33.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602895, gene) Scaffold attachment factor b; SAFBOMIM


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