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> Protein (NX_Q15427)
Protein (NX_Q15427)
Protein
Gene SymbolSF3B4 to neXtProt (NX_Q15427)
DescriptionSplicing factor 3B subunit 4
Chromosome1
Location1q21.2 (149895209 ~ 149900236) to Ensembl
Sequene Features : Isoforms 1, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 43 3
2014-09-19protein level
1 29 3
2014-05-27protein level
1 29 3
2014-02-25protein level
1 28 3
2013-12-09protein level
1 27 3
2013-11-01protein level
1 26 3
2013-09-12protein level
1 26 3
2013-08-17protein level
1 26 3
2013-07-15protein level
1 15 3
2013-06-11protein level
1 15 3
2013-02-12protein level
1 4 3
2012-12-20protein level
1 4 3
2012-10-30protein level
1 4 3
2012-10-07protein level
1 4 3
2012-08-24protein level
1 0 3
2012-07-28protein level
1 0 3
2012-06-08protein level
1 0 3
2012-05-07protein level
1 2 3
2012-04-10protein level
1 2 3
2012-01-13protein level
1 0 3
2011-12-20protein level
1 0 3
2011-11-11protein level
1 0 3
2011-08-23protein level
1 0 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15427-1
12 0 0 44356.9924
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348469,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-348469,EBI-744674 SS18L1  
  .positive regulation of dendrite morphogenesis
.positive regulation of transcription, DNA-templated
.chromatin modification
  + 2 more...
.N/A .nBAF complex
.nuclear body
.nucleus
  + 3 more...
3 EBI-348469,EBI-1050106 BCAS2  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
4 EBI-348469,EBI-748817 SEC24D  
  .membrane organization
.COPII vesicle coating
.small molecule metabolic process
  + 8 more...
.zinc ion binding .perinuclear region of cytoplasm
.COPII vesicle coat
.ER to Golgi transport vesicle membrane
  + 3 more...
5 EBI-348469,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
6 EBI-348469,EBI-1383583 FRK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
  + 2 more...
7 EBI-348469,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
8 EBI-348469,EBI-2105393 UBASH3A  
  .negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
9 EBI-348469,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
10 EBI-348469,EBI-721525 RBM10  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
11 EBI-348469,EBI-749111 SF3B2  
  .viral process
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
12 EBI-348469,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
13 EBI-348469,EBI-357897 EFTUD2  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.GTP binding
.GTPase activity
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 4 more...
14 EBI-348469,EBI-538479 PRPF8  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.pre-mRNA intronic binding
.K63-linked polyubiquitin binding
.poly(A) RNA binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 3 more...
15 EBI-348469,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
16 EBI-348469,EBI-10293968 PPP1R16B  
  .positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
17 EBI-348469,EBI-7705033 WDR83  
  .mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .catalytic step 2 spliceosome
.cytoplasm
.spliceosomal complex
18 EBI-348469,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
19 EBI-348469,EBI-749353 METTL17  
  .translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
20 EBI-348469,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
21 EBI-348469,EBI-525456 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
22 EBI-348469,EBI-750484 FAM115A  
  .positive regulation of anion channel activity
.positive regulation of protein targeting to membrane
.negative regulation of cell migration
.transport
.ion channel binding .plasma membrane
23 EBI-348469,EBI-3936907 NUB1  
  .response to tumor necrosis factor
.response to interferon-gamma
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.N/A .cytoplasm
.nucleolus
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood229
bone97
bone marrow61
brain46
cervix226
connective tissue13
embryonic tissue155
eye129
heart11
intestine86
kidney47
liver73
lung116
lymph270
lymph node55
mammary gland99
muscle65
ovary147
pancreas131
pharynx24
placenta98
prostate110
skin213
spleen56
stomach177
testis34
thymus50
thyroid107
tonsil293
uterus150
vascular19
Health State
TissuesTPM*
normal55
breast (mammary gland) tumor128
cervical tumor115
chondrosarcoma36
colorectal tumor115
gastrointestinal tumor151
germ cell tumor106
glioma93
head and neck tumor44
kidney tumor72
leukemia201
liver tumor135
lung tumor233
lymphoma249
non-neoplasia20
ovarian tumor131
pancreatic tumor228
primitive neuroectodermal tumor of the CNS330
prostate cancer163
retinoblastoma301
skin tumor319
soft tissue/muscle tissue tumor151
uterine tumor221
Developmental Stage
TissuesTPM*
adult77
embryoid body142
blastocyst130
fetus32
infant255
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.5
adrenal gland21.5
appendix31.6
bone marrow31.4
cerebral cortex17.8
colon29
duodenum22
esophagus27.6
gallbladder25
heart muscle14.1
kidney20.6
liver12.4
lung26
lymph node31.5
ovary32.8
pancreas9.6
placenta28.7
prostate23.3
salivary gland18.3
skin32.1
small intestine23.7
spleen24.5
stomach19.8
testis37.5
thyroid gland28.5
urinary bladder28.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#154400, phenotype) Acrofacial dysostosis 1, nager type; AFD1OMIM
2(*605593, gene) Splicing factor 3b, subunit 4; SF3B4OMIM


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2014-2019 (C) Yonsei Proteome Research Center