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> Protein (NX_Q15464)
Protein (NX_Q15464)
Protein
Gene SymbolSHB to neXtProt (NX_Q15464)
DescriptionSH2 domain-containing adapter protein B
Chromosome9
Location9p13.2 (37919131 ~ 38069210) to Ensembl
Sequene Features : Isoforms 2, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 52 7
2014-09-19protein level
2 37 7
2014-05-27protein level
2 37 7
2014-02-25protein level
2 36 7
2013-12-09protein level
2 26 7
2013-11-01protein level
2 26 7
2013-09-12protein level
2 26 9
2013-08-17protein level
2 26 9
2013-07-15protein level
2 16 9
2013-06-11protein level
2 16 9
2013-02-12protein level
2 10 14
2012-12-20protein level
2 9 14
2012-10-30protein level
2 14 14
2012-10-07protein level
2 14 10
2012-08-24protein level
2 10 10
2012-07-28protein level
2 10 10
2012-06-08protein level
2 14 10
2012-05-07protein level
2 14 10
2012-04-10protein level
2 14 10
2012-01-13protein level
2 13 10
2011-12-20protein level
2 13 10
2011-11-11protein level
2 13 9
2011-08-23protein level
2 13 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15464-1
13 12 0 55007.9031
NX_Q15464-2
2 12 0 30683.6154
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4402156,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-4402156,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
3 EBI-4402156,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
brain12
cervix20
connective tissue13
embryonic tissue4
eye57
heart22
intestine30
kidney61
liver14
lung50
mammary gland19
muscle18
ovary197
pancreas28
pharynx24
pituitary gland60
placenta10
prostate5
skin33
stomach20
testis18
uterus21
vascular38
Health State
TissuesTPM*
normal19
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor25
germ cell tumor144
glioma9
head and neck tumor7
kidney tumor72
leukemia21
liver tumor20
lung tumor29
non-neoplasia20
ovarian tumor249
pancreatic tumor9
retinoblastoma21
skin tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult36
embryoid body14
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland2.5
appendix3
bone marrow3.5
cerebral cortex6.2
colon6
duodenum5.6
esophagus9
gallbladder9.6
heart muscle9.1
kidney9.6
liver16.9
lung8.4
lymph node2.2
ovary2
pancreas5.9
placenta4.7
prostate8
salivary gland9.4
skin4.4
small intestine4.7
spleen5.5
stomach9.7
testis3
thyroid gland6.1
urinary bladder5.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600314, gene) Shb adaptor protein; SHBOMIM


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