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> Protein (NX_Q15466)
Protein (NX_Q15466)
Protein
Gene SymbolNR0B2 to neXtProt (NX_Q15466)
DescriptionNuclear receptor subfamily 0 group B member 2
Chromosome1
Location1p36.11 (27237980 ~ 27240457) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of insulin secretion
.organ regeneration
  + 7 more...
.protein homodimerization activity
.protein domain specific binding
.transcription corepressor activity
  + 3 more...
.protein complex
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 2
2014-09-19protein level
1 31 2
2014-05-27protein level
1 31 2
2014-02-25protein level
1 31 2
2013-12-09protein level
1 21 2
2013-11-01protein level
1 20 2
2013-09-12protein level
1 20 0
2013-08-17protein level
1 20 0
2013-07-15protein level
1 17 0
2013-06-11protein level
1 17 0
2013-02-12protein level
1 12 0
2012-12-20protein level
1 12 0
2012-10-30protein level
1 12 0
2012-10-07protein level
1 12 0
2012-08-24protein level
1 13 0
2012-07-28protein level
1 14 0
2012-06-08protein level
1 14 0
2012-05-07protein level
1 13 0
2012-04-10protein level
1 13 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15466-1
9 0 0 28039.5875
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3910729,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-3910729,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
3 EBI-3910729,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
heart44
intestine4
kidney23
liver43
lung2
spleen18
stomach41
Health State
TissuesTPM*
normal7
gastrointestinal tumor16
liver tumor83
Developmental Stage
TissuesTPM*
adult2
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland7
duodenum63.4
gallbladder10
heart muscle10.2
kidney5.9
liver48.8
lung2.5
pancreas14.5
small intestine22
spleen10.2
stomach13.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#601665, phenotype) ObesityOMIM
2(*604630, gene) Nuclear receptor subfamily 0, group b, member 2; NR0B2OMIM


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