Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q15554)
Protein (NX_Q15554)
Protein
Gene SymbolTERF2 to neXtProt (NX_Q15554)
DescriptionTelomeric repeat-binding factor 2
Chromosome16
Location16q22.1 (69389464 ~ 69442474) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
  + 15 more...
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
  + 2 more...
.Golgi apparatus
.cytoplasm
.nucleoplasm
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 5
2014-09-19protein level
2 24 5
2014-05-27protein level
2 24 5
2014-02-25protein level
3 23 5
2013-12-09protein level
3 17 5
2013-11-01protein level
3 15 4
2013-09-12protein level
3 15 4
2013-08-17protein level
3 16 4
2013-07-15protein level
2 10 4
2013-06-11protein level
2 10 4
2013-02-12protein level
2 8 11
2012-12-20protein level
2 8 11
2012-10-30protein level
2 10 11
2012-10-07protein level
2 10 7
2012-08-24protein level
2 8 7
2012-07-28protein level
2 8 4
2012-06-08protein level
2 8 4
2012-05-07protein level
2 8 4
2012-04-10protein level
2 8 4
2012-01-13protein level
2 1 4
2011-12-20protein level
2 1 4
2011-11-11protein level
2 1 4
2011-08-23protein level
2 1 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15554-3
12 11 0 59556.4062
NX_Q15554-4
2 11 0 32277.6218
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-706637,EBI-621372 BLM  
  .cellular response to camptothecin
.cellular response to hydroxyurea
.cellular response to ionizing radiation
  + 25 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.annealing helicase activity
  + 9 more...
.pronucleus
.PML body
.nuclear matrix
  + 8 more...
2 EBI-706637,EBI-374847 ORC1  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.ATP binding
.chromatin binding
.DNA binding
.plasma membrane
.cytosol
.cytoplasm
  + 5 more...
3 EBI-706637,EBI-374957 ORC2  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.DNA replication origin binding .membrane
.plasma membrane
.centrosome
  + 6 more...
4 EBI-706637,EBI-368417 WRN  
  .nucleic acid phosphodiester bond hydrolysis
.cellular response to gamma radiation
.positive regulation of hydrolase activity
  + 23 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.3'-5' DNA helicase activity
  + 15 more...
.centrosome
.nucleolus
.nucleoplasm
5 EBI-706637,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
6 EBI-706637,EBI-717418 TINF2  
  .protein localization to chromosome, telomeric region
.negative regulation of epithelial cell proliferation
.protein localization to chromosome
  + 6 more...
.telomeric DNA binding .nuclear matrix
.perinucleolar chromocenter
.nucleoplasm
  + 3 more...
7 EBI-706637,EBI-3508943 DCLRE1B  
  .nucleic acid phosphodiester bond hydrolysis
.telomeric 3' overhang formation
.protection from non-homologous end joining at telomere
  + 4 more...
.5'-3' exonuclease activity .centrosome
.cytoplasm
.nucleus
.chromosome, telomeric region
8 EBI-706637,EBI-752420 POT1  
  .positive regulation of DNA strand elongation
.negative regulation of telomerase activity
.positive regulation of telomerase activity
  + 8 more...
.single-stranded telomeric DNA binding
.DEAD/H-box RNA helicase binding
.telomerase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
  + 2 more...
9 EBI-706637,EBI-750109 TERF2IP  
  .positive regulation of protein acetylation
.protein localization to chromosome, telomeric region
.positive regulation of NF-kappaB transcription factor activity
  + 11 more...
.DNA binding .cytoplasm
.nucleoplasm
.nuclear envelope
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder33
blood114
bone13
brain21
cervix41
connective tissue26
embryonic tissue23
eye52
heart11
intestine51
kidney18
larynx85
liver63
lung20
lymph22
lymph node55
mammary gland6
mouth60
muscle28
ovary19
pancreas18
parathyroid48
placenta14
prostate42
skin9
testis22
thyroid42
uterus25
vascular19
Health State
TissuesTPM*
normal26
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor33
germ cell tumor37
glioma18
head and neck tumor44
liver tumor52
lung tumor19
lymphoma41
non-neoplasia20
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
prostate cancer67
retinoblastoma64
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult33
embryoid body42
blastocyst32
fetus46
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.2
adrenal gland14.4
appendix19.7
bone marrow10.1
cerebral cortex23.9
colon14.8
duodenum11.7
esophagus13.9
gallbladder14.7
heart muscle11.7
kidney12.4
liver9.2
lung13.4
lymph node35.2
ovary18.6
pancreas9
placenta15.3
prostate12.9
salivary gland8.4
skin10.7
small intestine11.1
spleen15.4
stomach11.9
testis17.7
thyroid gland18
urinary bladder16.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602027, gene) Telomeric repeat-binding factor 2; TERF2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2020 (C) Yonsei Proteome Research Center