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> Protein (NX_Q15555)
Protein (NX_Q15555)
Protein
Gene SymbolMAPRE2 to neXtProt (NX_Q15555)
DescriptionMicrotubule-associated protein RP/EB family member 2
Chromosome18
Location18q12.1 (32556892 ~ 32723434) to Ensembl
Sequene Features : Isoforms 5, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.cell proliferation
.signal transduction
.mitotic nuclear division
.N/A .microtubule plus-end
.microtubule cytoskeleton
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 33 6
2014-09-19protein level
5 23 6
2014-05-27protein level
4 22 7
2014-02-25protein level
4 22 7
2013-12-09protein level
4 18 7
2013-11-01protein level
4 17 6
2013-09-12protein level
4 17 6
2013-08-17protein level
4 17 6
2013-07-15protein level
4 9 4
2013-06-11protein level
4 9 4
2013-02-12protein level
2 2 13
2012-12-20protein level
2 2 13
2012-10-30protein level
2 3 13
2012-10-07protein level
2 3 7
2012-08-24protein level
2 3 7
2012-07-28protein level
2 3 7
2012-06-08protein level
2 2 7
2012-05-07protein level
2 2 7
2012-04-10protein level
2 2 7
2012-01-13protein level
2 2 7
2011-12-20protein level
2 2 7
2011-11-11protein level
2 2 7
2011-08-23protein level
2 2 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15555-1
0 15 1 37008.0942
NX_Q15555-2
1 11 1 29072.4639
NX_Q15555-3
2 13 1 35718.433
NX_Q15555-4
1 11 1 30672.0573
NX_Q15555-5
1 13 1 32215.7914
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739717,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
2 EBI-739717,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
3 EBI-739717,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
4 EBI-739717,EBI-10236271 PAXIP1  
  .chorion development
.adipose tissue development
.positive regulation of transcription initiation from RNA polymerase II promoter
  + 13 more...
.N/A .histone methyltransferase complex
.nuclear matrix
.nucleus
5 EBI-739717,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
6 EBI-739717,EBI-1756205 TRAIP  
  .negative regulation of tumor necrosis factor-mediated signaling pathway
.cell proliferation
.signal transduction
.apoptotic process
.ligase activity
.zinc ion binding
.receptor signaling protein activity
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.nucleolus
7 EBI-739717,EBI-10205543 CRTAC1  
  .negative regulation of receptor binding
.olfactory bulb development
.axonal fasciculation
.calcium ion binding .extracellular exosome
.growth cone
.proteinaceous extracellular matrix
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland182
bladder66
blood89
bone41
bone marrow61
brain521
cervix103
connective tissue80
embryonic tissue65
esophagus49
eye86
heart78
intestine47
kidney113
larynx42
liver43
lung50
lymph90
lymph node111
mammary gland85
mouth181
muscle9
nerve193
ovary9
pancreas103
parathyroid48
pituitary gland302
placenta56
prostate15
skin61
spleen224
stomach104
testis59
thymus476
thyroid171
tonsil58
trachea38
umbilical cord145
uterus25
vascular251
Health State
TissuesTPM*
normal223
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor115
chondrosarcoma72
colorectal tumor44
esophageal tumor57
gastrointestinal tumor42
germ cell tumor106
glioma65
head and neck tumor134
kidney tumor203
leukemia74
liver tumor41
lung tumor29
lymphoma55
non-neoplasia103
ovarian tumor13
pancreatic tumor47
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma43
skin tumor55
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult80
embryoid body71
blastocyst16
neonate160
fetus267
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.5
adrenal gland59.2
appendix29.1
bone marrow18.7
cerebral cortex97.8
colon24.7
duodenum13.2
esophagus19.5
gallbladder47.2
heart muscle74.4
kidney15.7
liver21.4
lung30
lymph node39.3
ovary25.5
pancreas6.4
placenta23.2
prostate14.6
salivary gland14
skin14.2
small intestine17.4
spleen27.8
stomach27.5
testis7.5
thyroid gland24.3
urinary bladder34.8
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastLow
bronchusLow
cerebellumLow
cerebral cortexMedium
colonHigh
duodenumLow
gallbladderMedium
hippocampusMedium
lateral ventricleMedium
lymph nodeMedium
nasopharynxLow
pancreasMedium
placentaLow
rectumMedium
salivary glandLow
skin 1Low
small intestineLow
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisLow
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605789, gene) Microtubule-associated protein, rp/eb family, member 2; MAPRE2OMIM


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