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> Protein (NX_Q15560)
Protein (NX_Q15560)
Protein
Gene SymbolTCEA2 to neXtProt (NX_Q15560)
DescriptionTranscription elongation factor A protein 2
Chromosome20
Location20q13.33 (62681189 ~ 62703700) to Ensembl
Sequene Features : Isoforms 2, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 31 1
2014-09-19protein level
2 19 1
2014-05-27protein level
2 19 1
2014-02-25protein level
2 19 1
2013-12-09protein level
2 16 1
2013-11-01protein level
2 15 1
2013-09-12protein level
2 15 1
2013-08-17protein level
2 15 1
2013-07-15protein level
1 8 1
2013-06-11protein level
1 8 1
2013-02-12protein level
1 5 1
2012-12-20protein level
1 5 1
2012-10-30protein level
1 6 1
2012-10-07protein level
1 6 1
2012-08-24protein level
1 6 1
2012-07-28protein level
1 6 1
2012-06-08protein level
1 6 1
2012-05-07protein level
1 3 1
2012-04-10protein level
1 3 1
2012-01-13protein level
1 1 1
2011-12-20protein level
1 1 1
2011-11-11protein level
1 1 1
2011-08-23protein level
1 1 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15560-1
1 12 2 33578.9326
NX_Q15560-2
0 12 2 30549.348
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-710310,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
2 EBI-710310,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
3 EBI-710310,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-710310,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
5 EBI-710310,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
6 EBI-710310,EBI-707595 MARK3  
  .N/A .ATP binding
.protein serine/threonine kinase activity
.extracellular exosome
.plasma membrane
7 EBI-710310,EBI-739552 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
8 EBI-710310,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
9 EBI-710310,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
10 EBI-710310,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
11 EBI-710310,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
12 EBI-710310,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
13 EBI-710310,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
14 EBI-710310,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
15 EBI-710310,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
16 EBI-710310,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
17 EBI-710310,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
18 EBI-710310,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
19 EBI-710310,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
20 EBI-710310,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
21 EBI-710310,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
22 EBI-710310,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
23 EBI-710310,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
24 EBI-710310,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
25 EBI-710310,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
26 EBI-710310,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
27 EBI-710310,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone55
bone marrow20
brain64
cervix103
connective tissue13
ear124
embryonic tissue37
esophagus49
eye95
heart67
intestine4
lung2
mammary gland6
placenta10
spleen18
testis4
thymus25
Health State
TissuesTPM*
normal50
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma48
germ cell tumor3
glioma149
head and neck tumor14
kidney tumor43
leukemia42
liver tumor41
lung tumor68
non-neoplasia10
ovarian tumor131
pancreatic tumor57
primitive neuroectodermal tumor of the CNS78
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult54
embryoid body42
blastocyst32
fetus34
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.9
adrenal gland28
appendix11.7
bone marrow6.7
cerebral cortex43.8
colon8.1
duodenum6.8
esophagus11.3
gallbladder22.5
heart muscle23.6
kidney30.4
liver29.8
lung22.5
lymph node15
ovary41.6
pancreas10.8
placenta19
prostate31.1
salivary gland20
skin14.6
small intestine9.3
spleen26.5
stomach14.4
testis58.3
thyroid gland24.2
urinary bladder16
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604784, gene) Transcription elongation factor a, 2; TCEA2OMIM


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