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> Protein (NX_Q15583)
Protein (NX_Q15583)
Protein
Gene SymbolTGIF1 to neXtProt (NX_Q15583)
DescriptionHomeobox protein TGIF1
Chromosome18
Location18p11.31 (3411606 ~ 3458409) to Ensembl
Sequene Features : Isoforms 4, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.retina development in camera-type eye
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of fibroblast proliferation
  + 14 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 56 1
2014-09-19protein level
4 49 1
2014-05-27protein level
4 49 1
2014-02-25protein level
4 47 1
2013-12-09protein level
4 33 1
2013-11-01protein level
4 32 1
2013-09-12protein level
4 32 1
2013-08-17protein level
4 32 1
2013-07-15protein level
3 25 1
2013-06-11protein level
3 25 1
2013-02-12protein level
3 18 0
2012-12-20protein level
3 19 0
2012-10-30protein level
3 20 0
2012-10-07protein level
3 20 0
2012-08-24protein level
3 19 0
2012-07-28protein level
3 19 0
2012-06-08protein level
3 20 0
2012-05-07protein level
3 17 0
2012-04-10protein level
2 17 0
2012-01-13protein level
2 15 0
2011-12-20protein level
2 15 0
2011-11-11protein level
2 15 0
2011-08-23protein level
2 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15583-1
4 8 2 42985.492
NX_Q15583-2
0 8 2 29717.8818
NX_Q15583-3
1 7 2 31044.3963
NX_Q15583-4
1 7 2 27697.9455
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714215,EBI-740058 LGALS8  
  .T cell costimulation
.plasma cell differentiation
.carbohydrate binding .extracellular exosome
.membrane
.cytoplasm
.extracellular space
2 EBI-714215,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
3 EBI-714215,EBI-741533 CTBP2  
  .white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
4 EBI-714215,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-714215,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder66
blood73
bone55
brain10
cervix61
connective tissue40
embryonic tissue122
eye52
heart22
intestine47
kidney47
larynx127
liver19
lung56
lymph node44
mammary gland39
muscle47
ovary78
pancreas65
pharynx49
placenta74
prostate31
skin33
spleen18
stomach94
testis29
thymus12
thyroid64
uterus107
Health State
TissuesTPM*
normal42
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma72
colorectal tumor53
gastrointestinal tumor67
germ cell tumor26
glioma37
head and neck tumor59
kidney tumor29
leukemia52
liver tumor20
lung tumor29
non-neoplasia31
ovarian tumor26
pancreatic tumor104
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor71
uterine tumor110
Developmental Stage
TissuesTPM*
adult62
embryoid body114
blastocyst195
fetus35
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.8
adrenal gland28.1
appendix34.9
bone marrow20.3
cerebral cortex7.3
colon41.7
duodenum26.9
esophagus36.4
gallbladder58.3
heart muscle11.6
kidney36.5
liver28.8
lung39.5
lymph node22.6
ovary59.5
pancreas21.1
placenta54.8
prostate38.2
salivary gland32.3
skin26.1
small intestine26.5
spleen25.4
stomach27.8
testis24.6
thyroid gland52.2
urinary bladder71.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#142946, phenotype) Holoprosencephaly 4; HPE4OMIM
2(*602630, gene) Transforming growth factor-beta-induced factor; TGIFOMIM


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