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> Protein (NX_Q15599)
Protein (NX_Q15599)
Protein
Gene SymbolSLC9A3R2 to neXtProt (NX_Q15599)
DescriptionNa(+)/H(+) exchange regulatory cofactor NHE-RF2
Chromosome16
Location16p13.3 (2075357 ~ 2089027) to Ensembl
Sequene Features : Isoforms 3, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of phosphatidylinositol 3-kinase signaling
.protein complex assembly
.phosphatase binding
.protein C-terminus binding
.beta-catenin binding
.receptor binding
.extracellular exosome
.apical plasma membrane
.endomembrane system
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 29 5
2014-09-19protein level
3 26 5
2014-05-27protein level
3 26 5
2014-02-25protein level
3 26 5
2013-12-09protein level
3 14 5
2013-11-01protein level
3 14 5
2013-09-12protein level
3 14 6
2013-08-17protein level
3 14 6
2013-07-15protein level
2 11 5
2013-06-11protein level
2 11 5
2013-02-12protein level
2 7 8
2012-12-20protein level
2 3 8
2012-10-30protein level
2 10 8
2012-10-07protein level
2 10 4
2012-08-24protein level
2 10 4
2012-07-28protein level
2 10 4
2012-06-08protein level
2 11 4
2012-05-07protein level
2 10 4
2012-04-10protein level
2 10 4
2012-01-13protein level
2 14 4
2011-12-20protein level
2 14 4
2011-11-11protein level
2 14 4
2011-08-23protein level
2 14 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15599-1
0 18 0 37390.8574
NX_Q15599-2
1 16 0 36131.3036
NX_Q15599-3
2 11 0 24702.4839
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1149760,EBI-349854 CFTR  
  .positive regulation of voltage-gated chloride channel activity
.chloride transmembrane transport
.cellular response to cAMP
  + 20 more...
.PDZ domain binding
.enzyme binding
.chloride channel inhibitor activity
  + 6 more...
.extracellular exosome
.recycling endosome
.protein complex
  + 11 more...
2 EBI-1149760,EBI-8542350 SLC26A3  
  .regulation of nucleic acid-templated transcription
.cellular response to cAMP
.membrane hyperpolarization
  + 7 more...
.anion:anion antiporter activity
.chloride transmembrane transporter activity
.bicarbonate transmembrane transporter activity
  + 4 more...
.sperm midpiece
.brush border membrane
.apical plasma membrane
  + 3 more...
3 EBI-1149760,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
4 EBI-1149760,EBI-765995 LPAR2  
  .positive regulation of Rho protein signal transduction
.positive regulation of cytosolic calcium ion concentration
.activation of phospholipase C activity
  + 2 more...
.lysophosphatidic acid receptor activity
.lipid binding
.G-protein coupled receptor activity
.cell surface
.integral component of plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites451
brain29
connective tissue6
embryonic tissue14
eye9
intestine47
kidney14
larynx42
liver43
lung26
mammary gland66
muscle18
ovary39
pancreas103
placenta14
prostate142
salivary gland98
skin23
spleen74
testis20
thymus12
thyroid21
trachea19
uterus17
vascular19
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor32
colorectal tumor62
gastrointestinal tumor151
germ cell tumor3
glioma27
head and neck tumor29
kidney tumor14
leukemia10
liver tumor31
lung tumor58
non-neoplasia20
ovarian tumor52
pancreatic tumor199
prostate cancer260
skin tumor23
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult65
embryoid body14
blastocyst32
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue97.3
adrenal gland30.1
appendix17.9
cerebral cortex14.3
colon24.8
duodenum21.5
esophagus13.5
gallbladder36.2
heart muscle99.8
kidney64.8
liver96.9
lung118.5
lymph node19.2
ovary24
pancreas12.6
placenta43
prostate64.4
salivary gland102.6
skin11
small intestine24.2
spleen86.6
stomach69.8
testis20.1
thyroid gland41.1
urinary bladder28.9
Tissues
TissuesExpression level
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumLow
endometrium 1High
endometrium 2High
epididymisMedium
fallopian tubeHigh
gallbladderHigh
hippocampusLow
kidneyHigh
lateral ventricleLow
liverMedium
nasopharynxHigh
pancreasMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
small intestineMedium
stomach 1High
stomach 2High
thyroid glandMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606553, gene) Solute carrier family 9, member 3, regulator 2; SLC9A3R2OMIM


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