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> Protein (NX_Q15628)
Protein (NX_Q15628)
Protein
Gene SymbolTRADD to neXtProt (NX_Q15628)
DescriptionTumor necrosis factor receptor type 1-associated DEATH domain protein
Chromosome16
Location16q22.1 (67188083 ~ 67194201) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.programmed necrotic cell death
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
  + 17 more...
.death domain binding
.binding, bridging
.identical protein binding
  + 2 more...
.membrane raft
.receptor complex
.death-inducing signaling complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 0
2014-09-19protein level
1 18 0
2014-05-27protein level
1 18 0
2014-02-25protein level
1 18 0
2013-12-09protein level
1 12 0
2013-11-01protein level
1 12 0
2013-09-12protein level
1 12 0
2013-08-17protein level
1 12 0
2013-07-15protein level
1 7 0
2013-06-11protein level
1 7 0
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 1 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 0 0
2011-12-20protein level
1 0 0
2011-11-11protein level
1 0 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15628-1
3 9 0 34225.7117
NX_Q15628-2
0 9 0 27886.5959
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359215,EBI-297888 KRT18  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
2 EBI-359215,EBI-299451 TNFRSF1A  
  .death-inducing signaling complex assembly
.cellular response to estradiol stimulus
.cellular response to mechanical stimulus
  + 29 more...
.tumor necrosis factor-activated receptor activity .synapse
.membrane raft
.receptor complex
  + 10 more...
3 EBI-359215,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bone13
bone marrow20
brain14
embryonic tissue4
esophagus49
eye9
heart44
intestine47
kidney75
liver19
lung53
lymph22
lymph node111
mammary gland33
mouth15
ovary19
pancreas37
parathyroid145
placenta7
prostate36
skin14
spleen93
testis6
thymus25
thyroid21
tonsil58
trachea38
uterus25
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor42
chondrosarcoma36
colorectal tumor44
esophageal tumor57
germ cell tumor7
glioma46
head and neck tumor14
kidney tumor29
leukemia42
liver tumor20
lung tumor58
lymphoma13
non-neoplasia41
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult24
embryoid body14
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.1
adrenal gland6.9
appendix13.7
bone marrow3.9
cerebral cortex2.7
colon9.6
duodenum9.8
esophagus5.2
gallbladder5.7
heart muscle2.7
kidney9.1
liver3.8
lung9.4
lymph node10.9
ovary3.5
pancreas3.7
placenta5.4
prostate12.2
salivary gland8.1
skin10.1
small intestine8.2
spleen17.2
stomach20.6
testis3.1
thyroid gland8.5
urinary bladder5.5
Tissues
TissuesExpression level
adrenal glandMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebral cortexLow
cervix, uterineHigh
colonLow
duodenumLow
endometrium 1High
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
hippocampusLow
kidneyLow
lateral ventricleLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
parathyroid glandMedium
placentaMedium
prostateLow
rectumLow
salivary glandLow
skin 1Low
skin 2Low
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1Medium
stomach 2Low
testisLow
thyroid glandMedium
tonsilHigh
urinary bladderLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603500, gene) Tumor necrosis factor receptor 1-associated death domain protein;OMIM


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