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> Protein (NX_Q15633)
Protein (NX_Q15633)
Protein
Gene SymbolTARBP2 to neXtProt (NX_Q15633)
DescriptionRISC-loading complex subunit TARBP2
Chromosome12
Location12q13.13 (53894705 ~ 53900215) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of defense response to virus by host
.regulation of viral transcription
.positive regulation of viral genome replication
  + 8 more...
.pre-miRNA binding
.protein homodimerization activity
.miRNA binding
  + 3 more...
.RISC-loading complex
.perinuclear region of cytoplasm
.micro-ribonucleoprotein complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 0
2014-09-19protein level
2 26 0
2014-05-27protein level
2 26 0
2014-02-25protein level
2 26 0
2013-12-09protein level
2 24 0
2013-11-01protein level
2 24 0
2013-09-12protein level
2 24 0
2013-08-17protein level
2 24 0
2013-07-15protein level
2 13 0
2013-06-11protein level
2 13 0
2013-02-12protein level
2 7 2
2012-12-20protein level
2 7 2
2012-10-30protein level
2 7 2
2012-10-07protein level
2 7 1
2012-08-24protein level
2 7 1
2012-07-28protein level
2 7 1
2012-06-08protein level
2 8 1
2012-05-07protein level
2 5 1
2012-04-10protein level
2 5 1
2012-01-13protein level
2 3 1
2011-12-20protein level
2 3 1
2011-11-11protein level
2 3 1
2011-08-23protein level
2 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15633-1
1 13 0 39014.5525
NX_Q15633-2
1 13 0 36892.675
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-978581,EBI-713955 PRKRA  
  .positive regulation of intrinsic apoptotic signaling pathway
.skeletal system morphogenesis
.positive regulation of catalytic activity
  + 11 more...
.poly(A) RNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.perinuclear region of cytoplasm
.membrane
.cytosol
  + 2 more...
2 EBI-978581,EBI-640775 EIF2AK2  
  .regulation of hematopoietic stem cell differentiation
.regulation of hematopoietic stem cell proliferation
.regulation of hematopoietic progenitor cell differentiation
  + 27 more...
.poly(A) RNA binding
.protein phosphatase type 2A regulator activity
.ATP binding
  + 5 more...
.perinuclear region of cytoplasm
.membrane
.ribosome
  + 3 more...
3 EBI-978581,EBI-6913056 ADAR  
  .negative regulation of RNA interference
.hematopoietic stem cell homeostasis
.negative regulation of type I interferon-mediated signaling pathway
  + 25 more...
.metal ion binding
.poly(A) RNA binding
.double-stranded RNA adenosine deaminase activity
.DNA binding
.supraspliceosomal complex
.membrane
.cytoplasm
  + 3 more...
4 EBI-978581,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
5 EBI-978581,EBI-740355 STRBP  
  .mechanosensory behavior
.spermatid development
.multicellular organismal development
.poly(A) RNA binding
.single-stranded RNA binding
.double-stranded RNA binding
.DNA binding
.microtubule cytoskeleton
.cytoplasm
.nucleus
6 EBI-978581,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
7 EBI-978581,EBI-2462313 ZNF346  
  .positive regulation of apoptotic process .poly(A) RNA binding
.enzyme binding
.zinc ion binding
.double-stranded RNA binding
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
8 EBI-978581,EBI-395506 DICER1  
  .positive regulation of miRNA metabolic process
.RNA phosphodiester bond hydrolysis, endonucleolytic
.hair follicle cell proliferation
  + 47 more...
.pre-miRNA binding
.metal ion binding
.miRNA binding
  + 6 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ARC complex
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland60
ascites25
bladder66
blood49
bone27
brain31
connective tissue13
embryonic tissue61
eye43
heart44
intestine51
kidney23
liver43
lung23
lymph22
lymph node89
mammary gland39
mouth15
muscle37
ovary59
pancreas28
placenta74
prostate36
salivary gland148
skin66
stomach10
testis4
thymus62
thyroid64
uterus30
Health State
TissuesTPM*
normal36
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
chondrosarcoma24
gastrointestinal tumor25
germ cell tumor37
head and neck tumor37
kidney tumor14
leukemia42
liver tumor93
lung tumor29
lymphoma180
non-neoplasia10
ovarian tumor78
pancreatic tumor47
primitive neuroectodermal tumor of the CNS173
prostate cancer57
retinoblastoma43
skin tumor103
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult35
embryoid body71
blastocyst48
fetus26
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.4
adrenal gland13.4
appendix18.7
bone marrow8.8
cerebral cortex11.5
colon13.1
duodenum17.6
esophagus12
gallbladder18.2
heart muscle9.8
kidney17.1
liver9.6
lung19.1
lymph node22.6
ovary15
pancreas10.6
placenta26.3
prostate15.6
salivary gland15.5
skin22.9
small intestine12.3
spleen20.7
stomach16.9
testis20.2
thyroid gland17.5
urinary bladder18.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605053, gene) Tar rna-binding protein 2; TARBP2OMIM


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