Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q15637)
Protein (NX_Q15637)
Protein
Gene SymbolSF1 to neXtProt (NX_Q15637)
DescriptionSplicing factor 1
Chromosome11
Location11q13.1 (64532078 ~ 64546258) to Ensembl
Sequene Features : Isoforms 7, Variants 88, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of nucleic acid-templated transcription
.regulation of steroid biosynthetic process
.negative regulation of smooth muscle cell proliferation
  + 7 more...
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.transcription corepressor activity
.ribosome
.spliceosomal complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 88 14
2014-09-19protein level
7 66 14
2014-05-27protein level
7 63 14
2014-02-25protein level
7 63 13
2013-12-09protein level
7 54 13
2013-11-01protein level
7 49 12
2013-09-12protein level
7 49 11
2013-08-17protein level
7 49 11
2013-07-15protein level
7 32 10
2013-06-11protein level
7 32 10
2013-02-12protein level
7 12 41
2012-12-20protein level
6 12 37
2012-10-30protein level
6 13 37
2012-10-07protein level
6 13 7
2012-08-24protein level
6 6 7
2012-07-28protein level
6 6 7
2012-06-08protein level
6 21 7
2012-05-07protein level
6 21 7
2012-04-10protein level
6 21 7
2012-01-13protein level
6 21 7
2011-12-20protein level
6 23 7
2011-11-11protein level
6 23 7
2011-08-23protein level
6 23 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15637-1
0 16 0 68285.7089
NX_Q15637-2
1 17 0 68589.0293
NX_Q15637-3
2 15 0 67233.6306
NX_Q15637-4
0 17 0 59673.7519
NX_Q15637-5
5 16 0 71706.0456
NX_Q15637-6
3 16 0 61849.7746
NX_Q15637-7
0 14 0 65328.2134
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744603,EBI-725145 CIAO1  
  .small molecule metabolic process
.iron-sulfur cluster assembly
.positive regulation of cell proliferation
  + 2 more...
.N/A .CIA complex
.MMXD complex
2 EBI-744603,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
3 EBI-744603,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
4 EBI-744603,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
5 EBI-744603,EBI-749955 TRIM69  
  .apoptotic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nuclear speck
.plasma membrane
.cytoplasm
.nucleus
6 EBI-744603,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland273
ascites25
bladder234
blood212
bone153
bone marrow164
brain165
cervix164
connective tissue100
embryonic tissue253
esophagus49
eye148
heart22
intestine150
kidney132
larynx85
liver107
lung161
lymph225
lymph node256
mammary gland125
mouth211
muscle56
nerve64
ovary137
pancreas107
parathyroid48
pharynx49
pituitary gland60
placenta151
prostate131
salivary gland246
skin185
spleen206
stomach83
testis206
thymus188
thyroid150
tonsil235
trachea173
uterus142
vascular135
Health State
TissuesTPM*
normal136
adrenal tumor316
bladder carcinoma56
breast (mammary gland) tumor150
cervical tumor86
chondrosarcoma169
colorectal tumor168
esophageal tumor57
gastrointestinal tumor92
germ cell tumor250
glioma158
head and neck tumor179
kidney tumor130
leukemia402
liver tumor166
lung tumor223
lymphoma166
non-neoplasia82
ovarian tumor105
pancreatic tumor152
primitive neuroectodermal tumor of the CNS220
prostate cancer144
retinoblastoma301
skin tumor239
soft tissue/muscle tissue tumor191
uterine tumor33
Developmental Stage
TissuesTPM*
adult134
embryoid body314
blastocyst244
neonate96
fetus154
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue137.5
adrenal gland112.8
appendix163.7
bone marrow316.8
cerebral cortex113.2
colon109.2
duodenum104.1
esophagus82
gallbladder110.3
heart muscle66.4
kidney93.5
liver93
lung135.1
lymph node175.4
ovary196.3
pancreas64.5
placenta109.6
prostate128.9
salivary gland93.7
skin124.6
small intestine110
spleen183.2
stomach112.1
testis163.7
thyroid gland127
urinary bladder93.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusHigh
cerebellumHigh
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
epididymisHigh
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
spleenLow
stomach 1Medium
stomach 2High
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601516, gene) Splicing factor 1; SF1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2020 (C) Yonsei Proteome Research Center