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> Protein (NX_Q15654)
Protein (NX_Q15654)
Protein
Gene SymbolTRIP6 to neXtProt (NX_Q15654)
DescriptionThyroid receptor-interacting protein 6
Chromosome7
Location7q22.1 (100464760 ~ 100471076) to Ensembl
Sequene Features : Isoforms 3, Variants 73, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 73 11
2014-09-19protein level
3 58 11
2014-05-27protein level
3 57 11
2014-02-25protein level
3 57 4
2013-12-09protein level
3 43 4
2013-11-01protein level
3 41 4
2013-09-12protein level
3 41 4
2013-08-17protein level
3 41 4
2013-07-15protein level
1 23 4
2013-06-11protein level
1 23 4
2013-02-12protein level
1 17 5
2012-12-20protein level
1 16 5
2012-10-30protein level
1 17 5
2012-10-07protein level
1 17 5
2012-08-24protein level
1 17 5
2012-07-28protein level
1 17 5
2012-06-08protein level
1 20 5
2012-05-07protein level
1 20 5
2012-04-10protein level
1 20 5
2012-01-13protein level
1 16 5
2011-12-20protein level
1 16 5
2011-11-11protein level
1 16 5
2011-08-23protein level
1 16 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15654-1
21 1 0 50255.3195
NX_Q15654-2
2 4 0 10595.3307
NX_Q15654-3
1 4 0 8272.1553
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742327,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
2 EBI-742327,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
3 EBI-742327,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
4 EBI-742327,EBI-744798 TRAF3IP2  
  .immunoglobulin secretion
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.intracellular signal transduction
  + 3 more...
.N/A .N/A
5 EBI-742327,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
6 EBI-742327,EBI-10188927 CTAG2  
  .N/A .N/A .centrosome
7 EBI-742327,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
8 EBI-742327,EBI-353997 GNAI2  
  .regulation of calcium ion transport
.cell division
.negative regulation of synaptic transmission
  + 17 more...
.metal ion binding
.G-protein beta/gamma-subunit complex binding
.GTP binding
  + 3 more...
.extracellular exosome
.membrane raft
.vesicle
  + 8 more...
9 EBI-742327,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
10 EBI-742327,EBI-356254 SLC25A6  
  .regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
11 EBI-742327,EBI-745290 HOXB9  
  .cell chemotaxis
.canonical Wnt signaling pathway
.embryonic skeletal system development
  + 4 more...
.sequence-specific DNA binding .mitochondrion
.nucleoplasm
12 EBI-742327,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
13 EBI-742327,EBI-1050897 CNTF  
  .ciliary neurotrophic factor-mediated signaling pathway
.neuron development
.muscle organ morphogenesis
  + 7 more...
.growth factor activity
.interleukin-6 receptor binding
.ciliary neurotrophic factor receptor binding
.cytoplasm
.extracellular space
14 EBI-742327,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
15 EBI-742327,EBI-742314 HOXA9  
  .negative regulation of myeloid cell differentiation
.endothelial cell activation
.multicellular organismal development
  + 2 more...
.sequence-specific DNA binding
.enzyme binding
.nucleoplasm
.nucleus
16 EBI-742327,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
17 EBI-742327,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
18 EBI-742327,EBI-742557 RFX3  
  .positive regulation of type B pancreatic cell development
.type B pancreatic cell maturation
.epithelial cilium movement involved in determination of left/right asymmetry
  + 12 more...
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.transcription factor complex
.nucleus
.nuclear chromatin
19 EBI-742327,EBI-945980 ATN1  
  .neuron apoptotic process
.maintenance of cell polarity
.cell migration
  + 4 more...
.protein domain specific binding
.transcription corepressor activity
.perinuclear region of cytoplasm
.cell junction
.nuclear matrix
  + 3 more...
20 EBI-742327,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
21 EBI-742327,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
22 EBI-742327,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
23 EBI-742327,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
24 EBI-742327,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
25 EBI-742327,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
26 EBI-742327,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
27 EBI-742327,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
28 EBI-742327,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
29 EBI-742327,EBI-702370 TRIM29  
  .negative regulation of protein localization to nucleus
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
30 EBI-742327,EBI-2108053 NEDD9  
  .cell division
.actin filament bundle assembly
.regulation of growth
  + 5 more...
.N/A .lamellipodium
.cell cortex
.focal adhesion
  + 5 more...
31 EBI-742327,EBI-372619 GSE1  
  .N/A .N/A .N/A
32 EBI-742327,EBI-10241319 POM121L1P  
  .N/A .N/A .N/A
33 EBI-742327,EBI-10248148 -  
  .N/A .N/A .N/A
34 EBI-742327,EBI-10248548 RNF213  
  .protein autoubiquitination
.protein ubiquitination
.ATPase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane
.cytoplasm
.nucleolus
35 EBI-742327,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
36 EBI-742327,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
37 EBI-742327,EBI-7844656 TTLL10  
  .cellular protein modification process .N/A .N/A
38 EBI-742327,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
39 EBI-742327,EBI-8634060 MSRB3  
  .protein repair
.response to oxidative stress
.peptide-methionine (R)-S-oxide reductase activity
.zinc ion binding
.endoplasmic reticulum
.mitochondrion
40 EBI-742327,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
41 EBI-742327,EBI-749333 C5orf55  
  .N/A .N/A .extracellular region
42 EBI-742327,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
43 EBI-742327,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
.microtubule
.cytoplasm
.nucleus
44 EBI-742327,EBI-10277551 NEU4  
  .small molecule metabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 7 more...
.exo-alpha-(2->8)-sialidase activity
.exo-alpha-(2->6)-sialidase activity
.exo-alpha-(2->3)-sialidase activity
.exo-alpha-sialidase activity
.lysosomal lumen
.organelle inner membrane
.lysosome
.mitochondrion
45 EBI-742327,EBI-710402 PPP1R16A  
  .N/A .protein phosphatase type 1 regulator activity .plasma membrane
46 EBI-742327,EBI-10294579 KIR2DL4  
  .regulation of immune response
.signal transduction
.cellular defense response
.transmembrane signaling receptor activity .membrane
.integral component of plasma membrane
.plasma membrane
47 EBI-742327,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
48 EBI-742327,EBI-8645371 KLK15  
  .N/A .serine-type peptidase activity
.serine-type endopeptidase activity
.extracellular region
49 EBI-742327,EBI-749353 METTL17  
  .translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
50 EBI-742327,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
51 EBI-742327,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
52 EBI-742327,EBI-747601 TRAPPC2L  
  .ER to Golgi vesicle-mediated transport .N/A .perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
.cytoplasm
53 EBI-742327,EBI-10326390 SIK3  
  .protein phosphorylation .ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
54 EBI-742327,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
55 EBI-742327,EBI-750484 FAM115A  
  .positive regulation of anion channel activity
.positive regulation of protein targeting to membrane
.negative regulation of cell migration
.transport
.ion channel binding .plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland151
ascites276
bladder33
blood57
bone83
bone marrow20
brain53
cervix536
connective tissue46
ear124
embryonic tissue169
esophagus49
eye134
heart33
intestine86
kidney109
larynx42
liver116
lung140
lymph90
lymph node11
mammary gland66
mouth75
muscle28
ovary256
pancreas103
pharynx98
placenta123
prostate94
salivary gland148
skin170
spleen37
stomach52
testis43
thymus50
thyroid128
trachea19
uterus116
vascular19
Health State
TissuesTPM*
normal79
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor260
chondrosarcoma84
colorectal tumor53
esophageal tumor57
gastrointestinal tumor126
germ cell tumor75
glioma149
head and neck tumor134
kidney tumor217
leukemia95
liver tumor145
lung tumor243
lymphoma69
non-neoplasia72
ovarian tumor210
pancreatic tumor190
primitive neuroectodermal tumor of the CNS55
prostate cancer48
skin tumor239
soft tissue/muscle tissue tumor15
uterine tumor122
Developmental Stage
TissuesTPM*
adult94
embryoid body100
blastocyst244
fetus71
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25
adrenal gland21.2
appendix14.3
bone marrow7.7
cerebral cortex11
colon13.5
duodenum8.2
esophagus25.7
gallbladder28.8
heart muscle17.6
kidney37.1
liver17.4
lung24.6
lymph node11
ovary28.4
pancreas13.9
placenta22.7
prostate30.2
salivary gland30.2
skin36.4
small intestine10
spleen15.3
stomach20.3
testis17.4
thyroid gland24.7
urinary bladder25.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602933, gene) Thyroid hormone receptor interactor 6; TRIP6OMIM


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